Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction

por Shin, Minwook, Meda Krishnamurthy, Pranathi, Devi, Gitali, Watts, Jonathan K.
Publicado 2022

Detecting chromatin interactions between and along sister chromatids with SisterC

por Oomen, Marlies E., Hedger, Adam K., Watts, Jonathan K., Dekker, Job
Publicado 2020

Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing

por Chen, Zexiang, Devi, Gitali, Arif, Amena, Zamore, Phillip D., Sontheimer, Erik J., Watts, Jonathan K.
Publicado 2022

Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters

por Watts, Jonathan K., Yu, Dongbo, Charisse, Klaus, Montaillier, Christophe, Potier, Pierre, Manoharan, Muthiah, Corey, David R.
Publicado 2010

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

por Maiti, Atanu, Hedger, Adam K., Myint, Wazo, Balachandran, Vanivilasini, Watts, Jonathan K., Schiffer, Celia A., Matsuo, Hiroshi
Publicado 2022

2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity

por Watts, Jonathan K., Choubdar, Niloufar, Sadalapure, Kashinath, Robert, Francis, Wahba, Alexander S., Pelletier, Jerry, Mario Pinto, B., Damha, Masad J.
Publicado 2007

Differential stability of 2′F-ANA•RNA and ANA•RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility

por Watts, Jonathan K., Martín-Pintado, Nerea, Gómez-Pinto, Irene, Schwartzentruber, Jeremy, Portella, Guillem, Orozco, Modesto, González, Carlos, Damha, Masad J.
Publicado 2010

Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope

por Bamidele, Nathan, Zhang, Han, Dong, Xiaolong, Gaston, Nicholas, Cheng, Haoyang, Kelly, Karen, Watts, Jonathan K., Xie, Jun, Gao, Guangping, Sontheimer, Erik J.
Publicado 2023

Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs’ dystrophy

por Hu, Jiaxin, Rong, Ziye, Gong, Xin, Zhou, Zhengyang, Sharma, Vivek K, Xing, Chao, Watts, Jonathan K, Corey, David R, Mootha, V Vinod
Publicado 2018

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing

por Deleavey, Glen F., Watts, Jonathan K., Alain, Tommy, Robert, Francis, Kalota, Anna, Aishwarya, Veenu, Pelletier, Jerry, Gewirtz, Alan M., Sonenberg, Nahum, Damha, Masad J.
Publicado 2010

Consensus Guidelines for the Design and In Vitro Preclinical Efficacy Testing N-of-1 Exon Skipping Antisense Oligonucleotides

por Aartsma-Rus, Annemieke, Garanto, Alejandro, van Roon-Mom, Willeke, McConnell, Erin M., Suslovitch, Victoria, Yan, Winston X., Watts, Jonathan K., Yu, Timothy W.
Publicado 2023

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing

por Mir, Aamir, Alterman, Julia F., Hassler, Matthew R., Debacker, Alexandre J., Hudgens, Edward, Echeverria, Dimas, Brodsky, Michael H., Khvorova, Anastasia, Watts, Jonathan K., Sontheimer, Erik J.
Publicado 2018

Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA

por Pendergraff, Hannah M., Krishnamurthy, Pranathi Meda, Debacker, Alexandre J., Moazami, Michael P., Sharma, Vivek K., Niitsoo, Liisa, Yu, Yong, Tan, Yen Nee, Haitchi, Hans Michael, Watts, Jonathan K.
Publicado 2017

An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy

por Goddard, Layla R., Mardle, Charlotte E., Gneid, Hassan, Ball, Ciara G., Gowers, Darren M., Atkins, Helen S., Butt, Louise E., Watts, Jonathan K., Vincent, Helen A., Callaghan, Anastasia J.
Publicado 2021

G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects

por Wang, Feng, Calvo-Roitberg, Ezequiel, Rembetsy-Brown, Julia M, Fang, Minggang, Sousa, Jacquelyn, Kartje, Zachary J, Krishnamurthy, Pranathi Meda, Lee, Jonathan, Green, Michael R, Pai, Athma A, Watts, Jonathan K
Publicado 2022

Genome-wide detection of CRISPR editing in vivo using GUIDE-tag

por Liang, Shun-Qing, Liu, Pengpeng, Smith, Jordan L., Mintzer, Esther, Maitland, Stacy, Dong, Xiaolong, Yang, Qiyuan, Lee, Jonathan, Haynes, Cole M., Zhu, Lihua Julie, Watts, Jonathan K., Sontheimer, Erik J., Wolfe, Scot A., Xue, Wen
Publicado 2022

Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo

por Zhang, Han, Kelly, Karen, Lee, Jonathan, Echeverria, Dimas, Cooper, David, Panwala, Rebecca, Chen, Zexiang, Gaston, Nicholas, Newby, Gregory A., Xie, Jun, Liu, David R., Gao, Guangping, Wolfe, Scot A., Khvorova, Anastasia, Watts, Jonathan K., Sontheimer, Erik J.
Publicado 2023

Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD

por Krishnan, Gopinath, Raitcheva, Denitza, Bartlett, Daniel, Prudencio, Mercedes, McKenna-Yasek, Diane M., Douthwright, Catherine, Oskarsson, Björn E., Ladha, Shafeeq, King, Oliver D., Barmada, Sami J., Miller, Timothy M., Bowser, Robert, Watts, Jonathan K., Petrucelli, Leonard, Brown, Robert H., Kankel, Mark W., Gao, Fen-Biao
Publicado 2022

5′-Modifications improve potency and efficacy of DNA donors for precision genome editing

por Ghanta, Krishna S, Chen, Zexiang, Mir, Aamir, Dokshin, Gregoriy A, Krishnamurthy, Pranathi M, Yoon, Yeonsoo, Gallant, Judith, Xu, Ping, Zhang, Xiao-Ou, Ozturk, Ahmet Rasit, Shin, Masahiro, Idrizi, Feston, Liu, Pengpeng, Gneid, Hassan, Edraki, Alireza, Lawson, Nathan D, Rivera-Pérez, Jaime A, Sontheimer, Erik J, Watts, Jonathan K, Mello, Craig C
Publicado 2021

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts

por Shin, Minwook, Chan, Io Long, Cao, Yuming, Gruntman, Alisha M, Lee, Jonathan, Sousa, Jacquelyn, Rodríguez, Tomás C, Echeverria, Dimas, Devi, Gitali, Debacker, Alexandre J, Moazami, Michael P, Krishnamurthy, Pranathi Meda, Rembetsy-Brown, Julia M, Kelly, Karen, Yukselen, Onur, Donnard, Elisa, Parsons, Teagan J, Khvorova, Anastasia, Sontheimer, Erik J, Maehr, René, Garber, Manuel, Watts, Jonathan K
Publicado 2022