High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH(2)) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

por Weaver, Richard E., Mobarec, Juan C., Wigglesworth, Mark J., Reynolds, Christopher A., Donnelly, Dan
Publicado 2017

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells

por Penman, Sophie L., Sharma, Parveen, Aerts, Hélène, Park, B. Kevin, Weaver, Richard J., Chadwick, Amy E.
Publicado 2019

Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs

por Ayre, Jack, Redmond, Joanna M., Vitulli, Giovanni, Tomlinson, Laura, Weaver, Richard, Comeo, Eleonora, Bosquillon, Cynthia, Stocks, Michael J.
Publicado 2022

Beta lactam hypersensitivities

por Azoury, Marie Eliane*, Scornet, Noémie*, Delluc, Stéphanie, Delarue-Cochin, Sandrine, Nhim, Cathy, Maillere, Bernard, Weaver, Richard, Claude, Nancy, Joseph, Delphine, Pallardy, Marc
Publicado 2014

Pharmacokinetics of N,N-dimethyltryptamine in Humans

por Good, Meghan, Joel, Zelah, Benway, Tiffanie, Routledge, Carol, Timmermann, Chris, Erritzoe, David, Weaver, Richard, Allen, Graham, Hughes, Charlotte, Topping, Helen, Bowman, Amy, James, Ellen
Publicado 2023

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

por Dragovic, Sanja, Vermeulen, Nico P. E., Gerets, Helga H., Hewitt, Philip G., Ingelman‐Sundberg, Magnus, Park, B. Kevin, Juhila, Satu, Snoeys, Jan, Weaver, Richard J.
Publicado 2016

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

por Atienzar, Franck A., Blomme, Eric A., Chen, Minjun, Hewitt, Philip, Kenna, J. Gerry, Labbe, Gilles, Moulin, Frederic, Pognan, Francois, Roth, Adrian B., Suter-Dick, Laura, Ukairo, Okechukwu, Weaver, Richard J., Will, Yvonne, Dambach, Donna M.
Publicado 2016

The evolving role of investigative toxicology in the pharmaceutical industry

por Pognan, Francois, Beilmann, Mario, Boonen, Harrie C. M., Czich, Andreas, Dear, Gordon, Hewitt, Philip, Mow, Tomas, Oinonen, Teija, Roth, Adrian, Steger-Hartmann, Thomas, Valentin, Jean-Pierre, Van Goethem, Freddy, Weaver, Richard J., Newham, Peter
Publicado 2023

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and De...

por Sison-Young, Rowena L. C., Mitsa, Dimitra, Jenkins, Rosalind E., Mottram, David, Alexandre, Eliane, Richert, Lysiane, Aerts, Hélène, Weaver, Richard J., Jones, Robert P., Johann, Esther, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Christopher E. P., Kitteringham, Neil R., Park, B. Kevin
Publicado 2015

Challenges and approaches for the development of safer immunomodulatory biologics

por Sathish, Jean G., Sethu, Swaminathan, Bielsky, Marie-Christine, de Haan, Lolke, French, Neil S., Govindappa, Karthik, Green, James, Griffiths, Christopher E. M., Holgate, Stephen, Jones, David, Kimber, Ian, Moggs, Jonathan, Naisbitt, Dean J., Pirmohamed, Munir, Reichmann, Gabriele, Sims, Jennifer, Subramanyam, Meena, Todd, Marque D., Van Der Laan, Jan Willem, Weaver, Richard J., Park, B. Kevin
Publicado 2013

A systems approach reveals species differences in hepatic stress response capacity

por Russomanno, Giusy, Sison-Young, Rowena, Livoti, Lucia A, Coghlan, Hannah, Jenkins, Rosalind E, Kunnen, Steven J, Fisher, Ciarán P, Reddyhoff, Dennis, Gardner, Iain, Rehman, Adeeb H, Fenwick, Stephen W, Jones, Andrew R, Vermeil De Conchard, Guy, Simonin, Gilles, Bertheux, Helene, Weaver, Richard J, Johnson, Robert L, Liguori, Michael J, Clausznitzer, Diana, Stevens, James L, Goldring, Christopher E, Copple, Ian M
Publicado 2023

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

por Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Publicado 2016

7th Drug hypersensitivity meeting: part two

por Elera, Javier Dionicio, Boteanu, Cosmin, Blanco, Maria Aranzazu Jimenez, Gonzalez-Mendiola, Rosario, García, Irene Carrasco, Alvarez, Antonio, Martinez, Jose Julio Laguna, Garrido, Jaume Martí, Barona, Carla Torán, Chorda, Carolina Perales, Salgueiro, Ramón López, Palacios, Miguel Díaz, De Rojas, Dolores Hernández Fernández, Acar, Emre Ali, Aktas, Ayse, Ermertcan, Aylin Türel, Temiz, Peyker, Lin, Chien-Yio, Hui, Chung-Yee Rosaline, Chang, Ya-Ching, Yang, Chih-Hsun, Chung, Wen-Hung, Carolino, Fabrícia, Silva, Diana, De Castro, Eunice Dias, Cernadas, Josefina R., Ensina, Luis Felipe, Aranda, Carolina, Nunes, Ines Camelo, Lacerda, Alex, Martins, Ana Maria, Goudouris, Ekaterini, Ribeiro, Marcia, Da Silva Franco, José Francisco, Queiroz, Leandra, Solé, Dirceu, Dalgiç, Ceyda Tunakan, Sin, Aytül Zerrin, Günsen, Fatma Düsünür, Bulut, Gökten, Ardeniz, Fatma Ömür, Gülbahar, Okan, Gökmen, Emine Nihal Mete, Kokuludag, Ali, De Francisco, Ana M. Montoro, De Vicente Jiménez, Talía Mª, Mendoza Parra, Adriana M., Burgos Pimentel, Angella M., Luque, Amelia García, Amaral, Luis, Leão, Leonor Carneiro, Pinto, Nicole, Belo, Joana, Marques, João, Carreiro-Martins, Pedro, Leiria-Pinto, Paula, Chaabane, Amel, Romdhane, Haifa Ben, Fredj, Nadia Ben, Chadly, Zohra, Boughattas, Naceur A., Aouam, Karim, Uyttebroek, Astrid P., Bridts, Chris H., Romano, Antonino, Ebo, Didier G., Sabato, Vito, Lopes, Anabela, Cosme, Joana, Aguiar, Rita, Lourenço, Tatiana, Paes, Maria-João, Spínola-Santos, Amélia, Pereira-Barbosa, Manuel, Cruz, Cíntia Rito, Dos Reis, Rute Pereira, Tomaz, Elza, Pires, Ana Paula, Inácio, Filipe, Benito-Garcia, Filipe, Mota, Inês, Correia, Magna, Gaspar, Ângela, Chambel, Marta, Piedade, Susana, Morais-Almeida, Mário, Nakonechna, Alla, Antipkin, Yurij, Umanets, Tetiana, Pineda, Fernando, Arribas, Francisca, Lapshyn, Volodymyr, Miranda, Pablo Andrés, De La Cruz Hoyos, Bautista, Blanco, Aranzazu Jimenez, Del Pozo, Marta, Vultaggio, Alessandra, Nencini, Francesca, Pratesi, Sara, Matucci, Andrea, Maggi, Enrico, Cegec, Ivana, Nahal, Danica Juricic, Turk, Viktorija Erdeljic, Aumiler, Matea Radacic, Ausperger, Ksenija Makar, Kraljickovic, Iva, Simic, Iveta, Yamaguchi, Yukie, Watanabe, Tomoya, Satoh, Megumi, Tanegashima, Tomohiko, Oda, Kayoko, Wada, Hidefumi, Aihara, Michiko, Lee, Jaechun Jason, Choi, Jay Chol, Lee, Hwa Young, Fernandes, Rosa-Anita Rodrigues, Faria, Emília, Pita, Joana, Sousa, Nuno, Ribeiro, Carmelita, Carrapatoso, Isabel, Bom, Ana Todo, Rodolfo, Ana, Dias-Castro, Eunice, Voronova, Marina, Valle, Diana Kury, Coronel, Verónica Pacheco, Chordá, Carolina Perales, Madamba, Roselle Catherine Yu, Ferrer, Marta, Goikoetxea, Maria Jose, D’Amelio, Carmen, Bernad, Amalia, Vega, Olga, Gastaminza, Gabriel, Bibián, Beatriz Pola, Salazar, Marina Lluncor, Vilà-Nadal, Gemma, Roman, Ana María Fiandor, Ortega, Javier Dominguez, Muñoz, Miguel Gonzalez, Gancedo, Santiago Quirce, Moreno, Maria Rosario Cabañas, Hofmeier, Kathrin Scherer, Barzylovych, Vladyslava, Pola, Beatriz, Lluncor, Marina, Fiandor, Ana, Bellón, Teresa, Domínguez, Javier, Quirce, Santiago, Yang, Min-Suk, Kim, Sun-Sin, Kim, Sae-Hoon, Kang, Hye-Ryun, Park, Heung-Woo, Cho, Sang-Heon, Min, Kyung-Up, Chang, Yoon-Seok, Delahaye, Clémence, Flabbee, Jenny, Waton, Julie, Bauvin, Olivia, Barbaud, Annick, Fadhel, Najah Ben, Gulin, Sandra Jerkovic, Chiriac, Anca, Cardoso, Bárbara Kong, Viseu, Regina, Moreira, Ana, Cadinha, Susana, Neves, Ana Castro, Barreira, Patrícia, Malheiro, Daniela, Da Silva, J. P. Moreira, Jurakic-Toncic, Ružica, Ljubojevic, Suzana, Turcic, Petra, Gilissen, Liesbeth, Huygens, Sara, Goossens, An, Andreu, Inmaculada, Romero, Alicia Martinez, Cabezas, Pau Gomez, Parejo, Pedro Ayuso, Del Carmen Plaza-Serón, Maria, Doña, Inmaculada, Blanca-López, Natalia, Flores, Carlos, Galindo, María Luisa, Molina, Ana, Perkins, James Richard, Cornejo-García, José Antonio, García-Agúndez, José Augusto, García-Martín, Elena, Campo, Paloma, Canto, María Gabriela, Blanca, Miguel, Guéant-Rodríguez, Rosa María, Jurado-Escobar, Raquel, Barrionuevo, Esther, Salas, María, Canto, Gabriela, Guéant, Jean-Louis, Usui, Toru, Tailor, Arun, Faulkner, Lee, Farrell, John, Alfirevic, Ana, Kevin Park, B., Naisbitt, Dean J., Trelles, Oswaldo, Guerrero, María Auxiliadora, Upton, Alex, Ueta, Mayumi, Sawai, Hiromi, Sotozono, Chie, Tokunaga, Katushi, Kinoshita, Shigeru, Sukasem, Chonlaphat, Satapornpong, Patompong, Tempark, Therdpong, Rerknimitr, Pawinee, Pairayayutakul, Kulprapat, Klaewsongkram, Jettanong, Koomdee, N., Jantararoungtong, T., Santon, S., Puangpetch, A., Intusoma, U., Tassaneeyakul, W., Theeramoke, V., Ramirez, Elena, Borobia, Alberto Manuel, Tong, Hoi, Castañer, Jose Luis, De Abajo, Francisco José, Galvao, Violeta Régnier, Pavlos, Rebecca, Mckinnon, Elizabeth, Williams, Kristina, Beeghly-Fadiel, Alicia, Redwood, Alec, Phillips, Elizabeth, Castells, Mariana, Boni, Elisa, Russello, Marina, Mauro, Marina, Ue, Kok Loong, Rutkowski, Krzysztof, Gomis, Victor Soriano, Ferre, Jorge Frances, Rodriguez, Angel Esteban, Reig, Vicente Cantó, Sanchez, Javier Fernandez, Breynaert, Christine, Van Hoeyveld, Erna, Schrijvers, Rik, Blanco, Aranzazu Jimenez, Irigoyen, Raquel Fuentes, Collado, Daniel, Vida, Yolanda, Najera, Francisco, Perez-Inestrosa, Ezequiel, Mesa-Antunez, Pablo, Mayorga, Cristobalina, Torres, María José, Tannert, Line K., Mortz, Charlotte G., Skov, Per Stahl, Bindslev-Jensen, Carsten, Pfützner, Wolfgang, Dörnbach, Hannah, Visse, Johanna, Rauber, Michele, Möbs, Christian, Elzagallaai, Abdelbaset A., Chow, Lindsey, Abuzgaia, Awatif M., Rieder, Michael J., Trubiano, Jason, Woolnough, Emily, Stautins, Kaija, Cheng, Christina, Kato, Kenichi, Azukizawa, Hiroaki, Hanafusa, Takaaki, Katayama, Ichiro, Fujiyama, Toshiharu, Hashizume, Hideo, Umayahara, Takatsune, Ito, Taisuke, Tokura, Yoshiki, Silar, Mira, Zidarn, Mihaela, Rupnik, Helena, Korosec, Peter, Redwood, Alec James, Strautins, Kaija, White, Katie, Chopra, Abha, Konvinse, Katherine, Leary, Shay, Mallal, Simon, Cabañas, Rosario, Fiandor, Ana María, Sullivan, Andrew, Whitaker, Paul, Peckham, Daniel, Haw, Wei Yann, Polak, Marta E., Mcguire, Carolann, Ardern-Jones, Michael R., Aoyama, Yumi, Shiohara, Tetsuo, Correia, Sara, Gelincik, Asli, Demir, Semra, Sen, Fatma, Bozbey, Hamza Ugur, Olgac, Muge, Unal, Derya, Coskun, Raif, Colakoglu, Bahauddin, Buyuozturk, Suna, Çatin-Aktas, Esin, Deniz, Gunnur, Laguna, Jose Julio, Dionicio, J., Fernandez, Tahia, Olazabal, I., Ruiz, Maria Dolores, Torres, Maria José, Lafuente, Alberto, Núñez, Jorge, Fernández, Tahia Diana, Palomares, Francisca, Fernández, Rubén, Sanchez, Maria Isabel, Fernandez, Tahía, Ruiz, Arturo, Ariza, Adriana, Alonso, Amalia Bernad, Garófalo, Carmen D’Amelio, Matute, Olga Vega, Puga, Marta Ferrer, Lapresa, María José Goikoetxea, Lasarte, Gabriel Gastaminza, Thinnes, Antonia, Merk, Hans F., Baron, Jens Malte, Leverkus, Martin, Balakirski, Galina, Gibson, Andrew, Ogese, Monday, Al-Attar, Zaid, Yaseen, Fiazia, Meng, Xiaoli, Jenkins, Rozalind, Farrel, John, Alhilali, Khetam, Xue, Yanni, Illing, Patricia, Mifsud, Nicole, Fettke, Heidi, Lai, Jeffrey, Ho, Rebecca, Kwan, Patrick, Purcell, Anthony, Ogese, Monday O., Betts, Catherine, Thomson, Paul, Alhaidari, Mohammad, Berry, Neill, O’Neill, Paul M., Alzahrani, Abdulaziz, Azoury, Marie Eliane, Fili, Lucia, Bechara, Rami, Scornet, Noémie, Nhim, Cathy, Weaver, Richard, Claude, Nancy, Joseph, Delphine, Maillere, Bernard, Parronchi, Paola, Pallardy, Marc, Villani, Axel Patrice, Rozières, Aurore, Bensaïd, Benoît, Tardieu, Mathilde, Albert, Floriane, Mutez, Virginie, Baysal, Tugba, Maryanski, Janet, Nicolas, Jean-François, Kanagawa, Osami, Vocanson, Marc, Hung, Shuen-Iu, Harrison, Caroline J., Jenkins, Rosalind E., French, Neil S., Montañez, Maria Isabel, Fernandez, Tahia D., Martin-Serrano, Angela, Torres, Maria Jose, Molina, Noemi, Wood, Sally, Pirmohamed, Munir, Montañez, María Isabel, Martín-Serrano, Ángela, Pérez-Inestrosa, Ezequiel, Pérez-Sala, Dolores, Guzmán, Antonio E., Ko, Tai-Ming, Chen, Yuan-Tsong, Wu, Jer-Yuarn, Sánchez-Gómez, Francisco J., González-Morena, Juan M., Torres, María J., Arreola, Alejandra Monroy, Corona, Jesus Agustin Badillo, Flores, Silvia Mendez, Cherit, Judith Dominguez, Figueroa, Noe Valentin Duran, Flores, Jose Luis Castrejon, Perkins, James, Pérez-Alzate, Diana, Bogas, Gador, Torres, María J, Marti, Luis Mario Tubella, De La Losa, Fernando Pineda, Poves, Francisca Arribas, Lopez, Jaime Tubella, Santiago, Teodora Lopez
Publicado 2016