A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors

por El Meskini, Rajaa, Iacovelli, Anthony J., Kulaga, Alan, Gumprecht, Michelle, Martin, Philip L., Baran, Maureen, Householder, Deborah B., Van Dyke, Terry, Weaver Ohler, Zoë
Publicado 2015

Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation...

por Szabova, Ludmila, Gordon, Melanie B., Lu, Lucy, Pate, Nathan, Bassel, Laura, Iacovelli, Anthony J., Karim, Baktiar, Homan, Philip J., Householder, Deborah B., Guerin, Theresa M., Burkett, Sandra, Day, Amanda M., Custer, Wendi, Weaver Ohler, Zoe
Publicado 2022

Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for huma...

por Wei, Bih‐Rong, Michael, Helen T., Halsey, Charles H.C., Peer, Cody J., Adhikari, Amit, Dwyer, Jennifer E., Hoover, Shelley B., El Meskini, Rajaa, Kozlov, Serguei, Weaver Ohler, Zoe, Figg, William. D., Merlino, Glenn, Simpson, R. Mark
Publicado 2016

Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models

por Lissa, Delphine, Takahashi, Nobuyuki, Desai, Parth, Manukyan, Irena, Schultz, Christopher W., Rajapakse, Vinodh, Velez, Moises J., Mulford, Deborah, Roper, Nitin, Nichols, Samantha, Vilimas, Rasa, Sciuto, Linda, Chen, Yuanbin, Guha, Udayan, Rajan, Arun, Atkinson, Devon, El Meskini, Rajaa, Weaver Ohler, Zoe, Thomas, Anish
Publicado 2022