Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6

por Thurman, Morgan, van Doorn, Jacob, Danzer, Barbara, Webb, Thomas R, Stamm, Stefan
Publicado 2017

Inhibition or Knockdown of ABC Transporters Enhances Susceptibility of Adult and Juvenile Schistosomes to Praziquantel

por Kasinathan, Ravi S., Sharma, Lalit Kumar, Cunningham, Charles, Webb, Thomas R., Greenberg, Robert M.
Publicado 2014

Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism

por Kumar, Gyanendra, Cuypers, Maxime, Webby, Richard R, Webb, Thomas R, White, Stephen W
Publicado 2021

Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency

por Kyei, George B., Meng, Shanshan, Ramani, Rashmi, Niu, Austin, Lagisetti, Chandraiah, Webb, Thomas R., Ratner, Lee
Publicado 2018

HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia

por Thénoz, Morgan, Vernin, Céline, Mortada, Hussein, Karam, Maroun, Pinatel, Christiane, Gessain, Antoine, Webb, Thomas R, Auboeuf, Didier, Wattel, Eric, Mortreux, Franck
Publicado 2014

Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates

por Shi, Yihui, Joyner, Amanda S, Shadrick, William, Palacios, Gustavo, Lagisetti, Chandraiah, Potter, Philip M, Sambucetti, Lidia C, Stamm, Stefan, Webb, Thomas R
Publicado 2015

Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease

por Beylkin, Diane, Kumar, Gyanendra, Zhou, Wei, Park, Jaehyeon, Jeevan, Trushar, Lagisetti, Chandraiah, Harfoot, Rhodri, Webby, Richard J., White, Stephen W., Webb, Thomas R.
Publicado 2017

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

por Shi, Yihui, Bray, Walter, Smith, Alexander J., Zhou, Wei, Calaoagan, Joy, Lagisetti, Chandraiah, Sambucetti, Lidia, Crews, Phillip, Lokey, R. Scott, Webb, Thomas R.
Publicado 2020

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

por DuBois, Rebecca M., Slavish, P. Jake, Baughman, Brandi M., Yun, Mi-Kyung, Bao, Ju, Webby, Richard J., Webb, Thomas R., White, Stephen W.
Publicado 2012

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

por Wu, Gang, Fan, Liying, Edmonson, Michael N., Shaw, Timothy, Boggs, Kristy, Easton, John, Rusch, Michael C., Webb, Thomas R., Zhang, Jinghui, Potter, Philip M.
Publicado 2018

Sudemycin E influences alternative splicing and changes chromatin modifications

por Convertini, Paolo, Shen, Manli, Potter, Philip M., Palacios, Gustavo, Lagisetti, Chandraiah, de la Grange, Pierre, Horbinski, Craig, Fondufe-Mittendorf, Yvonne N., Webb, Thomas R., Stamm, Stefan
Publicado 2014

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia

por Xargay-Torrent, Sílvia, López-Guerra, Mónica, Rosich, Laia, Montraveta, Arnau, Roldán, Jocabed, Rodríguez, Vanina, Villamor, Neus, Aymerich, Marta, Lagisetti, Chandraiah, Webb, Thomas R., López-Otín, Carlos, Campo, Elias, Colomer, Dolors
Publicado 2015

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

por Chan, John D., Cupit, Pauline M., Gunaratne, Gihan S., McCorvy, John D., Yang, Yang, Stoltz, Kristen, Webb, Thomas R., Dosa, Peter I., Roth, Bryan L., Abagyan, Ruben, Cunningham, Charles, Marchant, Jonathan S.
Publicado 2017

FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease–Associated Genetic Variant and Influences Monocyte Transendothelial Migration

por Yang, Xu, Yang, Wei, McVey, David G., Zhao, Guojun, Hu, Jinfu, Poston, Robin N., Ren, Meixia, Willeit, Karin, Coassin, Stefan, Willeit, Johann, Webb, Thomas R., Samani, Nilesh J., Mayr, Manuel, Kiechl, Stefan, Ye, Shu
Publicado 2020

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

por Shirai, Cara Lunn, White, Brian S., Tripathi, Manorama, Tapia, Roberto, Ley, James N., Ndonwi, Matthew, Kim, Sanghyun, Shao, Jin, Carver, Alexa, Saez, Borja, Fulton, Robert S., Fronick, Catrina, O'Laughlin, Michelle, Lagisetti, Chandraiah, Webb, Thomas R., Graubert, Timothy A., Walter, Matthew J.
Publicado 2017

The integrin ligand SVEP1 regulates GPCR‐mediated vasoconstriction via integrins α9β1 and α4β1

por Morris, Gavin E., Denniff, Matthew J., Karamanavi, Elisavet, Andrews, Sarah A., Kostogrys, Renata B., Bountziouka, Vasiliki, Ghaderi‐Najafabadi, Maryam, Shamkhi, Noor, McConnell, George, Kaiser, Michael A., Carleton, Laura, Schofield, Christine, Kessler, Thorsten, Rainbow, Richard D., Samani, Nilesh J., Webb, Thomas R.
Publicado 2022

Activating mutations in ALK provide a therapeutic target in neuroblastoma

por George, Rani E., Sanda, Takaomi, Hanna, Megan, Fröhling, Stefan, Luther, William, Zhang, Jianming, Ahn, Yebin, Zhou, Wenjun, London, Wendy B., McGrady, Patrick, Xue, Liquan, Zozulya, Sergey, Gregor, Vlad, Webb, Thomas R., Gray, Nathanael S., Gilliland, D. Gary, Diller, Lisa, Greulich, Heidi, Morris, Stephan W., Meyerson, Matthew, Look, A. Thomas
Publicado 2008

Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure

por Nath, Mintu, Romaine, Simon P.R., Koekemoer, Andrea, Hamby, Stephen, Webb, Thomas R., Nelson, Christopher P., Castellanos‐Uribe, Marcos, Papakonstantinou, Manolo, Anker, Stefan D., Lang, Chim C., Metra, Marco, Zannad, Faiez, Filippatos, Gerasimos, van Veldhuisen, Dirk J., Cleland, John G., Ng, Leong L., May, Sean T., Marelli‐Berg, Federica, Voors, Adriaan A., Timmons, James A., Samani, Nilesh J.
Publicado 2022

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention

por Inouye, Michael, Abraham, Gad, Nelson, Christopher P., Wood, Angela M., Sweeting, Michael J., Dudbridge, Frank, Lai, Florence Y., Kaptoge, Stephen, Brozynska, Marta, Wang, Tingting, Ye, Shu, Webb, Thomas R., Rutter, Martin K., Tzoulaki, Ioanna, Patel, Riyaz S., Loos, Ruth J.F., Keavney, Bernard, Hemingway, Harry, Thompson, John, Watkins, Hugh, Deloukas, Panos, Di Angelantonio, Emanuele, Butterworth, Adam S., Danesh, John, Samani, Nilesh J.
Publicado 2018

Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies

por Tu, Jian, Huo, Zijun, Yu, Yao, Zhu, Dandan, Xu, An, Huang, Mo-Fan, Hu, Ruifeng, Wang, Ruoyu, Gingold, Julian A., Chen, Yi-Hung, Tsai, Kuang-Lei, Forcioli-Conti, Nicolas R., Huang, Sarah X. L., Webb, Thomas R., Su, Jie, Bazer, Danielle A., Jia, Peilin, Yustein, Jason T., Wang, Lisa L., Hung, Mien-Chie, Zhao, Zhongming, Huff, Chad D., Shen, Jingnan, Zhao, Ruiying, Lee, Dung-Fang
Publicado 2022