The hybrid AAVP tool gets an upgrade

por Alves-Cruzeiro, João, Webster, Christopher P., Azzouz, Mimoun
Publicado 2019

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

por Webster, Christopher P., Smith, Emma F., Shaw, Pamela J., De Vos, Kurt J.
Publicado 2017

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy

por Webster, Christopher P., Smith, Emma F., Grierson, Andrew J., De Vos, Kurt J.
Publicado 2016

Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels

por Moller, Annekathrin, Bauer, Claudia S, Cohen, Rebecca N, Webster, Christopher P, De Vos, Kurt J
Publicado 2017

Ap4b1-knockout mouse model of hereditary spastic paraplegia type 47 displays motor dysfunction, aberrant brain morphology and ATG9A mislocalization

por Scarrott, Joseph M, Alves-Cruzeiro, João, Marchi, Paolo M, Webster, Christopher P, Yang, Zih-Liang, Karyka, Evangelia, Marroccella, Raffaele, Coldicott, Ian, Thomas, Hannah, Azzouz, Mimoun
Publicado 2023

SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction

por Marrone, Lara, Marchi, Paolo M, Webster, Christopher P, Marroccella, Raffaele, Coldicott, Ian, Reynolds, Steven, Alves-Cruzeiro, João, Yang, Zih-Liang, Higginbottom, Adrian, Khundadze, Mukhran, Shaw, Pamela J, Hübner, Christian A, Livesey, Matthew R, Azzouz, Mimoun
Publicado 2022

SMN-deficient cells exhibit increased ribosomal DNA damage

por Karyka, Evangelia, Berrueta Ramirez, Nelly, Webster, Christopher P, Marchi, Paolo M, Graves, Emily J, Godena, Vinay K, Marrone, Lara, Bhargava, Anushka, Ray, Swagat, Ning, Ke, Crane, Hannah, Hautbergue, Guillaume M, El-Khamisy, Sherif F, Azzouz, Mimoun
Publicado 2022

An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD

por Bauer, Claudia S., Cohen, Rebecca N., Sironi, Francesca, Livesey, Matthew R., Gillingwater, Thomas H., Highley, J. Robin, Fillingham, Daniel J., Coldicott, Ian, Smith, Emma F., Gibson, Yolanda B., Webster, Christopher P., Grierson, Andrew J., Bendotti, Caterina, De Vos, Kurt J.
Publicado 2022

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

por Webster, Christopher P, Smith, Emma F, Bauer, Claudia S, Moller, Annekathrin, Hautbergue, Guillaume M, Ferraiuolo, Laura, Myszczynska, Monika A, Higginbottom, Adrian, Walsh, Matthew J, Whitworth, Alexander J, Kaspar, Brian K, Meyer, Kathrin, Shaw, Pamela J, Grierson, Andrew J, De Vos, Kurt J
Publicado 2016

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation

por Bauer, Claudia S., Webster, Christopher P., Shaw, Allan C., Kok, Jannigje R., Castelli, Lydia M., Lin, Ya-Hui, Smith, Emma F., Illanes-Álvarez, Francisco, Higginbottom, Adrian, Shaw, Pamela J., Azzouz, Mimoun, Ferraiuolo, Laura, Hautbergue, Guillaume M., Grierson, Andrew J., De Vos, Kurt J.
Publicado 2022

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

por Allen, Scott P, Hall, Benjamin, Castelli, Lydia M, Francis, Laura, Woof, Ryan, Siskos, Alexandros P, Kouloura, Eirini, Gray, Elizabeth, Thompson, Alexander G, Talbot, Kevin, Higginbottom, Adrian, Myszczynska, Monika, Allen, Chloe F, Stopford, Matthew J, Hemingway, Jordan, Bauer, Claudia S, Webster, Christopher P, De Vos, Kurt J, Turner, Martin R, Keun, Hector C, Hautbergue, Guillaume M, Ferraiuolo, Laura, Shaw, Pamela J
Publicado 2019

C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

por Marchi, Paolo M, Marrone, Lara, Brasseur, Laurent, Coens, Audrey, Webster, Christopher P, Bousset, Luc, Destro, Marco, Smith, Emma F, Walther, Christa G, Alfred, Victor, Marroccella, Raffaele, Graves, Emily J, Robinson, Darren, Shaw, Allan C, Wan, Lai Mei, Grierson, Andrew J, Ebbens, Stephen J, De Vos, Kurt J, Hautbergue, Guillaume M, Ferraiuolo, Laura, Melki, Ronald, Azzouz, Mimoun
Publicado 2022