Exploring N-acyl-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-enes as 11β-HSD1 Inhibitors

por Leiva, Rosana, McBride, Andrew, Binnie, Margaret, Webster, Scott P., Vázquez, Santiago
Publicado 2018

Diclofenac Identified as a Kynurenine 3-Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques

por Shave, Steven, McGuire, Kris, Pham, Nhan T., Mole, Damian J., Webster, Scott P., Auer, Manfred
Publicado 2018

UFSRAT: Ultra-Fast Shape Recognition with Atom Types –The Discovery of Novel Bioactive Small Molecular Scaffolds for FKBP12 and 11βHSD1

por Shave, Steven, Blackburn, Elizabeth A., Adie, Jillian, Houston, Douglas R., Auer, Manfred, Webster, Scott P., Taylor, Paul, Walkinshaw, Malcolm D.
Publicado 2015

Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury

por Zheng, Xiaozhong, Zhang, Ailiang, Binnie, Margaret, McGuire, Kris, Webster, Scott P., Hughes, Jeremy, Howie, Sarah E. M., Mole, Damian J.
Publicado 2019

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

por Sooy, Karen, Noble, June, McBride, Andrew, Binnie, Margaret, Yau, Joyce L. W., Seckl, Jonathan R., Walker, Brian R., Webster, Scott P.
Publicado 2015

Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice

por Yau, Joyce L.W., Wheelan, Nicola, Noble, June, Walker, Brian R., Webster, Scott P., Kenyon, Christopher J., Ludwig, Mike, Seckl, Jonathan R.
Publicado 2015

β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction

por Liu, Xiaoxia, Turban, Sophie, Carter, Roderick N., Ahmad, Shakil, Ramage, Lynne, Webster, Scott P., Walker, Brian R., Seckl, Jonathan R., Morton, Nicholas M.
Publicado 2014

Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice

por Wheelan, Nicola, Webster, Scott P., Kenyon, Christopher J., Caughey, Sarah, Walker, Brian R., Holmes, Megan C., Seckl, Jonathan R., Yau, Joyce L.W.
Publicado 2015

Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure

por Turban, Sophie, Liu, Xiaoxia, Ramage, Lynne, Webster, Scott P., Walker, Brian R., Dunbar, Donald R., Mullins, John J., Seckl, Jonathan R., Morton, Nicholas M.
Publicado 2012

11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

por Mitić, Tijana, Shave, Steven, Semjonous, Nina, McNae, Iain, Cobice, Diego F., Lavery, Gareth G., Webster, Scott P., Hadoke, Patrick W.F., Walker, Brian R., Andrew, Ruth
Publicado 2013

Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)

por Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R
Publicado 2017

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

por Davidson, Callam T., Miller, Eileen, Muir, Morwenna, Dawson, John C., Lee, Martin, Aitken, Stuart, Serrels, Alan, Webster, Scott P., Homer, Natalie Z. M., Andrew, Ruth, Brunton, Valerie G., Hadoke, Patrick W. F., Walker, Brian R.
Publicado 2023

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

por Coutinho, Agnes E., Kipari, Tiina M. J., Zhang, Zhenguang, Esteves, Cristina L., Lucas, Christopher D., Gilmour, James S., Webster, Scott P., Walker, Brian R., Hughes, Jeremy, Savill, John S., Seckl, Jonathan R., Rossi, Adriano G., Chapman, Karen E.
Publicado 2016

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity...

por Fraser, Craig, Dawson, John C., Dowling, Reece, Houston, Douglas R., Weiss, Jason T., Munro, Alison F., Muir, Morwenna, Harrington, Lea, Webster, Scott P., Frame, Margaret C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2016

11Beta‐hydroxysteroid dehydrogenase‐1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis

por Zou, Xiantong, Ramachandran, Prakash, Kendall, Timothy J., Pellicoro, Antonella, Dora, Elena, Aucott, Rebecca L., Manwani, Kajal, Man, Tak Yung, Chapman, Karen E., Henderson, Neil C., Forbes, Stuart J., Webster, Scott P., Iredale, John P., Walker, Brian R., Michailidou, Zoi
Publicado 2018

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

por Hutchinson, Jonathan P., Rowland, Paul, Taylor, Mark R. D., Christodoulou, Erica M., Haslam, Carl, Hobbs, Clare I., Holmes, Duncan S., Homes, Paul, Liddle, John, Mole, Damian J., Uings, Iain, Walker, Ann L., Webster, Scott P., Mowat, Christopher G., Chung, Chun-wa
Publicado 2017

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis

por McBride, Andrew, Hoy, Anna M., Bamford, Mark J., Mossakowska, Danuta E., Ruediger, Martin P., Griggs, Jeremy, Desai, Sapna, Simpson, Kate, Caballero-Hernandez, Ivan, Iredale, John P., Pell, Theresa, Aucott, Rebecca L., Holmes, Duncan S., Webster, Scott P., Fallowfield, Jonathan A.
Publicado 2017

Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis

por Skouras, Christos, Zheng, Xiaozhong, Binnie, Margaret, Homer, Natalie Z. M., Murray, Toby B. J., Robertson, Darren, Briody, Lesley, Paterson, Finny, Spence, Heather, Derr, Lisa, Hayes, Alastair J., Tsoumanis, Andreas, Lyster, Dawn, Parks, Rowan W., Garden, O. James, Iredale, John P., Uings, Iain J., Liddle, John, Wright, Wayne L., Dukes, George, Webster, Scott P., Mole, Damian J.
Publicado 2016

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

por McNae, Iain W., Kinkead, James, Malik, Divya, Yen, Li-Hsuan, Walker, Martin K., Swain, Chris, Webster, Scott P., Gray, Nick, Fernandes, Peter M., Myburgh, Elmarie, Blackburn, Elizabeth A., Ritchie, Ryan, Austin, Carol, Wear, Martin A., Highton, Adrian J., Keats, Andrew J., Vong, Antonio, Dornan, Jacqueline, Mottram, Jeremy C., Michels, Paul A. M., Pettit, Simon, Walkinshaw, Malcolm D.
Publicado 2021

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

por Mole, Damian J, Webster, Scott P, Uings, Iain, Zheng, Xiaozhong, Binnie, Margaret, Wilson, Kris, Hutchinson, Jonathan P, Mirguet, Olivier, Walker, Ann, Beaufils, Benjamin, Ancellin, Nicolas, Trottet, Lionel, Bénéton, Véronique, Mowat, Christopher G, Wilkinson, Martin, Rowland, Paul, Haslam, Carl, McBride, Andrew, Homer, Natalie ZM, Baily, James E, Sharp, Matthew GF, Garden, O James, Hughes, Jeremy, Howie, Sarah EM, Holmes, Duncan S, Liddle, John, Iredale, John P
Publicado 2016