Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma

por Eisemann, Tanja, Wechsler-Reya, Robert J.
Publicado 2022

MEDB-66. Investigating intra-tumoral heterogeneity of extrachromosomal DNA in SHH medulloblastoma

por Chapman, Owen, Sridhar, Sunita, Wechsler-Reya, Robert J, Chavez, Lukas, Mesirov, Jill P
Publicado 2022

MBRS-12. A TRANSPOSON MUTAGENESIS SCREEN IDENTIFIES Rreb1 AS A DRIVER FOR GROUP 3 MEDULLOBLASTOMA

por Masihi, Meher Beigi, Lee, Catherine, Furnari, Grace A, Garancher, Alexandra, Wechsler-Reya, Robert J
Publicado 2020

Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth

por Qiu, Runxiang, Wu, Jun, Gudenas, Brian, Northcott, Paul A., Wechsler-Reya, Robert J., Lu, Qiang
Publicado 2021

Characterization of G-CSF receptor expression in medulloblastoma

por Paul, Megan Rose, Huo, Yuchen, Liu, Andrea, Lesperance, Jacqueline, Garancher, Alexandra, Wechsler-Reya, Robert J, Zage, Peter E
Publicado 2020

Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1

por Green, Mary J., Myat, Anna M., Emmenegger, Brian A., Wechsler-Reya, Robert J., Wilson, Leigh J., Wingate, Richard J. T.
Publicado 2014

Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development

por Miller, Tyler E., Wang, Jun, Sukhdeo, Kumar, Horbinski, Craig, Tesar, Paul J., Wechsler-Reya, Robert J., Rich, Jeremy N.
Publicado 2014

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma

por Chahal, Kirti Kandhwal, Li, Jie, Kufareva, Irina, Parle, Milind, Durden, Donald L., Wechsler-Reya, Robert J., Chen, Clark C., Abagyan, Ruben
Publicado 2019

Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor

por Dash, Radha Charan, Wen, Jiachen, Zaino, Angela M., Morel, Shana R., Chau, Lianne Q., Wechsler-Reya, Robert J., Hadden, M. Kyle
Publicado 2021

Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets

por Abbas, Zahra, George, Courtney, Ancliffe, Mathew, Howlett, Meegan, Jones, Anya C., Kuchibhotla, Mani, Wechsler-Reya, Robert J., Gottardo, Nicholas G., Endersby, Raelene
Publicado 2022

Subgroup-Enriched Pathways and Kinase Signatures in Medulloblastoma Patient-Derived Xenografts

por Leskoske, Kristin L., Garcia-Mansfield, Krystine, Sharma, Ritin, Krishnan, Aparna, Rusert, Jessica M., Mesirov, Jill P., Wechsler-Reya, Robert J., Pirrotte, Patrick
Publicado 2022

The long non-coding RNA SPRIGHTLY and its binding partner PTBP1 regulate exon 5 skipping of SMYD3 transcripts in group 4 medulloblastomas

por Lee, Bongyong, Katsushima, Keisuke, Pokhrel, Rudramani, Yuan, Menglang, Stapleton, Stacie, Jallo, George, Wechsler-Reya, Robert J, Eberhart, Charles G, Ray, Animesh, Perera, Ranjan J
Publicado 2022

DIPG-17. CD155 regulates cell growth and immune evasion in diffuse intrinsic pontine glioma

por Tzaridis, Theophilos, Eisemann, Tanja, Andrade, Augusto F, Hope, Jennifer L, Romero, Megan M, Becher, Oren J, Jabado, Nada, Bradley, Linda M, Wechsler-Reya, Robert J
Publicado 2022

BIOL-07. DISTINCTIVE FEATURES OF HIGH-GRADE GLIOMA MOUSE MODELS REVEALED BY SINGLE-NUCLEUS RNA-SEQUENCING GUIDE PRE-CLINICAL MODEL SELECTION

por Ernst, Kati, Okonechnikov, Konstantin, von Soosten, Laura, Hofmann, Nina, Mack, Norman, Schwalm, Benjamin, Wechsler-Reya, Robert J, Pfister, Stefan M, Thongjuea, Supat, Jones, David T W, Zuckermann, Marc
Publicado 2023

A population of Nestin expressing progenitors in the cerebellum exhibits increased tumorigenicity

por Li, Peng, Du, Fang, Yuelling, Larra W., Lin, Tiffany, Muradimova, Renata E., Tricarico, Rossella, Wang, Jun, Enikolopov, Grigori, Bellacosa, Alfonso, Wechsler-Reya, Robert J., Yang, Zeng-jie
Publicado 2013

Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma

por Chan, Tiffany S Y, Picard, Daniel, Hawkins, Cynthia E, Lu, Mei, Pfister, Stefan, Korshunov, Andrey, Roussel, Martine F, Wechsler-Reya, Robert J, Henkin, Jack, Bouffet, Eric, Huang, Annie
Publicado 2021

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

por Čančer, Matko, Hutter, Sonja, Holmberg, Karl O., Rosén, Gabriela, Sundström, Anders, Tailor, Jignesh, Bergström, Tobias, Garancher, Alexandra, Essand, Magnus, Wechsler-Reya, Robert J., Falk, Anna, Weishaupt, Holger, Swartling, Fredrik J.
Publicado 2019

DDEL-10. A NANOPARTICLE PLATFORM FOR INTRATHECAL DELIVERY OF THE HISTONE DEACETYLASE INHIBITOR (HDACi) PANOBINOSTAT IN METASTATIC OR RECURRENT MEDULLOBLASTOMA

por Chaudhuri, Sauradip, Mohammad, Afroz S, Zhang, Wenqui, Baker, Cassandra, Broughton, Colton W, Fowler, Martha J, Stabenfeldt, Sarah E, Wechsler-Reya, Robert J, Sandberg, David I, Elmquist, William F, Sirianni, Rachael W
Publicado 2020

Biallelic loss of GNAS in a patient with pediatric medulloblastoma

por Tokita, Mari J., Nahas, Shareef, Briggs, Benjamin, Malicki, Denise M., Mesirov, Jill P., Reyes, Iris Anne C., Farnaes, Lauge, Levy, Michael L., Kingsmore, Stephen F., Dimmock, David, Crawford, John R., Wechsler-Reya, Robert J.
Publicado 2019

Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells

por Li, Li, Grausam, Katie B., Wang, Jun, Lun, Melody P., Ohli, Jasmin, Lidov, Hart G. W., Calicchio, Monica L., Zeng, Erliang, Salisbury, Jeffrey L., Wechsler-Reya, Robert J., Lehtinen, Maria K., Schüller, Ulrich, Zhao, Haotian
Publicado 2016