Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery

por Pang, Luping, Weeks, Stephen D., Van Aerschot, Arthur
Publicado 2021

Structural insights into the activity and regulation of human Josephin-2

por Grasty, Kimberly C., Weeks, Stephen D., Loll, Patrick J.
Publicado 2019

Dissecting the Functional Role of the N-Terminal Domain of the Human Small Heat Shock Protein HSPB6

por Heirbaut, Michelle, Beelen, Steven, Strelkov, Sergei V., Weeks, Stephen D.
Publicado 2014

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

por Sillen, Machteld, Weeks, Stephen D., Strelkov, Sergei V., Declerck, Paul J.
Publicado 2020

Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases

por Muranova, Lydia K., Weeks, Stephen D., Strelkov, Sergei V., Gusev, Nikolai B.
Publicado 2015

The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8

por Shatov, Vladislav M., Weeks, Stephen D., Strelkov, Sergei V., Gusev, Nikolai B.
Publicado 2018

Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies

por Pang, Luping, Weeks, Stephen D., Juhás, Martin, Strelkov, Sergei V., Zitko, Jan, Van Aerschot, Arthur
Publicado 2021

Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases

por Weeks, Stephen D., Muranova, Lydia K., Heirbaut, Michelle, Beelen, Steven, Strelkov, Sergei V., Gusev, Nikolai B.
Publicado 2018

Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

por Pang, Luping, Zanki, Vladimir, Strelkov, Sergei V., Van Aerschot, Arthur, Gruic-Sovulj, Ita, Weeks, Stephen D.
Publicado 2022

MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes

por Baens, Mathijs, Bonsignore, Luca, Somers, Riet, Vanderheydt, Charlotte, Weeks, Stephen D., Gunnarsson, Jenny, Nilsson, Ewa, Roth, Robert G., Thome, Margot, Marynen, Peter
Publicado 2014

Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides

por Pang, Luping, Lenders, Stijn, Osipov, Evgenii M., Weeks, Stephen D., Rozenski, Jef, Piller, Tatiana, Cappoen, Davie, Strelkov, Sergei V., Van Aerschot, Arthur
Publicado 2022

Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors

por Zhang, Baole, Pang, Luping, Nautiyal, Manesh, De Graef, Steff, Gadakh, Bharat, Lescrinier, Eveline, Rozenski, Jef, Strelkov, Sergei V., Weeks, Stephen D., Van Aerschot, Arthur
Publicado 2020

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

por Vanmeert, Michiel, Razzokov, Jamoliddin, Mirza, Muhammad Usman, Weeks, Stephen D, Schepers, Guy, Bogaerts, Annemie, Rozenski, Jef, Froeyen, Mathy, Herdewijn, Piet, Pinheiro, Vitor B, Lescrinier, Eveline
Publicado 2019

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

por Vanmeert, Michiel, Razzokov, Jamoliddin, Mirza, Muhammad Usman, Weeks, Stephen D, Schepers, Guy, Bogaerts, Annemie, Rozenski, Jef, Froeyen, Mathy, Herdewijn, Piet, Pinheiro, Vitor B, Lescrinier, Eveline
Publicado 2019

Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors

por Osipov, Evgenii M., Munawar, Ali H., Beelen, Steven, Fearon, Daren, Douangamath, Alice, Wild, Conor, Weeks, Stephen D., Van Aerschot, Arthur, von Delft, Frank, Strelkov, Sergei V.
Publicado 2022

The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication

por Loffredo, Madeline, Lucero, Hector, Chen, Da-Yuan, O’Connell, Aoife, Bergqvist, Simon, Munawar, Ahmad, Bandara, Asanga, De Graef, Steff, Weeks, Stephen D., Douam, Florian, Saeed, Mohsan, Munawar, Ali H.
Publicado 2021