An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer

por Weinberger, Leor S, Shenk, Thomas
Publicado 2007

The HSV-1 ICP4 Transcriptional Auto-Repression Circuit Functions as a Transcriptional “Accelerator” Circuit

por Chaturvedi, Sonali, Engel, Ruth, Weinberger, Leor
Publicado 2020

Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies

por Metzger, Vincent T., Lloyd-Smith, James O., Weinberger, Leor S.
Publicado 2011

Fifteen Years Later: Hard and Soft Selection Sweeps Confirm a Large Population Number for HIV In Vivo

por Rouzine, Igor M., Coffin, John M., Weinberger, Leor S.
Publicado 2014

Exploiting Genetic Interference for Antiviral Therapy

por Tanner, Elizabeth J., Kirkegaard, Karla A., Weinberger, Leor S.
Publicado 2016

Comparative analysis between single-cell RNA-seq and single-molecule RNA FISH indicates that the pyrimidine nucleobase idoxuridine (IdU) globally amplifies transcriptional noise

por Calia, Giuliana P., Chen, Xinyue, Zuckerman, Binyamin, Weinberger, Leor S.
Publicado 2023

Dynamics of protein noise can distinguish between alternate sources of gene-expression variability

por Singh, Abhyudai, Razooky, Brandon S, Dar, Roy D, Weinberger, Leor S
Publicado 2012

Accelerated Immunodeficiency by Anti-CCR5 Treatment in HIV Infection

por Weinberger, Ariel D., Perelson, Alan S., Ribeiro, Ruy M., Weinberger, Leor S.
Publicado 2009

The Low Noise Limit in Gene Expression

por Dar, Roy D., Razooky, Brandon S., Weinberger, Leor S., Cox, Chris D., Simpson, Michael L.
Publicado 2015

RanDeL-Seq: a High-Throughput Method to Map Viral cis- and trans-Acting Elements

por Notton, Timothy, Glazier, Joshua J., Saykally, Victoria R., Thompson, Cassandra E., Weinberger, Leor S.
Publicado 2021

Noise-driven cellular heterogeneity in circadian periodicity

por Li, Yan, Shan, Yongli, Desai, Ravi V., Cox, Kimberly H., Weinberger, Leor S., Takahashi, Joseph S.
Publicado 2020

Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals

por Rast, Luke I., Rouzine, Igor M., Rozhnova, Ganna, Bishop, Lisa, Weinberger, Ariel D., Weinberger, Leor S.
Publicado 2016

Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean

por Razooky, Brandon S., Cao, Youfang, Hansen, Maike M. K., Perelson, Alan S., Simpson, Michael L., Weinberger, Leor S.
Publicado 2017

Transcriptional Bursting Explains the Noise–Versus–Mean Relationship in mRNA and Protein Levels

por Dar, Roy D., Shaffer, Sydney M., Singh, Abhyudai, Razooky, Brandon S., Simpson, Michael L., Raj, Arjun, Weinberger, Leor S.
Publicado 2016

A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters

por Chaturvedi, Sonali, Beutler, Nathan, Vasen, Gustavo, Pablo, Michael, Chen, Xinyue, Calia, Giuliana, Buie, Lauren, Rodick, Robert, Smith, Davey, Rogers, Thomas, Weinberger, Leor S.
Publicado 2022

Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy

por Mohri, Hiroshi, Perelson, Alan S., Tung, Keith, Ribeiro, Ruy M., Ramratnam, Bharat, Markowitz, Martin, Kost, Rhonda, Hurley, Weinberger, Leor, Cesar, Denise, Hellerstein, Marc K., Ho, David D.
Publicado 2001

A molecular mechanism for probabilistic bet hedging and its role in viral latency

por Chaturvedi, Sonali, Klein, Jonathan, Vardi, Noam, Bolovan-Fritts, Cynthia, Wolf, Marie, Du, Kelvin, Mlera, Luwanika, Calvert, Meredith, Moorman, Nathaniel J., Goodrum, Felicia, Huang, Bo, Weinberger, Leor S.
Publicado 2020

Disrupting autorepression circuitry generates ‘‘open-loop lethality’’ to yield escape-resistant antiviral agents

por Chaturvedi, Sonali, Pablo, Michael, Wolf, Marie, Rosas-Rivera, Daniel, Calia, Giuliana, Kumar, Arjun J., Vardi, Noam, Du, Kelvin, Glazier, Joshua, Ke, Ruian, Chan, Matilda F., Perelson, Alan S., Weinberger, Leor S.
Publicado 2023

Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents

por Chaturvedi, Sonali, Pablo, Michael, Wolf, Marie, Rosas-Rivera, Daniel, Calia, Giuliana, Kumar, Arjun J., Vardi, Noam, Du, Kelvin, Glazier, Joshua, Ke, Ruian, Chan, Matilda F., Perelson, Alan S., Weinberger, Leor S.
Publicado 2022

Dramatic Rise in Plasma Viremia after CD8(+) T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

por Jin, Xia, Bauer, Daniel E., Tuttleton, Sarah E., Lewin, Sharon, Gettie, Agegnehu, Blanchard, James, Irwin, Craig E., Safrit, Jeffrey T., Mittler, John, Weinberger, Leor, Kostrikis, Leondios G., Zhang, Linqi, Perelson, Alan S., Ho, David D.
Publicado 1999