HSP70 and FLT3-ITD: Targeting chaperone system to overcome drug resistance

por Yang, Jing, Weisberg, Ellen L.
Publicado 2021

Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition

por Weisberg, Ellen L., Sattler, Martin, Azab, Abdel Kareem, Eulberg, Dirk, Kruschinski, Anna, Manley, Paul W., Stone, Richard, Griffin, James D.
Publicado 2017

Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

por Hu, Chen, Zou, Fengming, Wang, Aoli, Miao, Weili, Liang, Qianmao, Weisberg, Ellen L., Wang, Yinsheng, Liu, Jing, Wang, Wenchao, Liu, Qingsong
Publicado 2021

Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming

por Bhanot, Haymanti, Weisberg, Ellen L., Reddy, Mamatha M., Nonami, Atsushi, Neuberg, Donna, Stone, Richard M., Podar, Klaus, Salgia, Ravi, Griffin, James D., Sattler, Martin
Publicado 2017

Correction to Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

por Kim, Hyung-Gu, Tan, Li, Weisberg, Ellen L., Liu, Feiyang, Canning, Peter, Choi, Hwan-Geun, Ezell, Scott, Zhao, Zheng, Wu, Hong, Wang, Jinhua, Mandinova, Anna, Bullock, Alex N., Liu, Qingsong, Lee, Sam W., Gray, Nathanael S.
Publicado 2014

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

por Bhanot, Haymanti, Reddy, Mamatha M., Nonami, Atsushi, Weisberg, Ellen L., Bonal, Dennis, Kirschmeier, Paul T., Salgia, Sabrina, Podar, Klaus, Galinsky, Ilene, Chowdary, Tirumala K., Neuberg, Donna, Tonon, Giovanni, Stone, Richard M., Asara, John, Griffin, James D., Sattler, Martin
Publicado 2015

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

por Kim, Hyung-Gu, Tan, Li, Weisberg, Ellen L., Liu, Feiyang, Canning, Peter, Choi, Hwan Geun, Ezell, Scott A., Wu, Hong, Zhao, Zheng, Wang, Jinhua, Mandinova, Anna, Griffin, James D., Bullock, Alex N., Liu, Qingsong, Lee, Sam W., Gray, Nathanael S.
Publicado 2013

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

por Weisberg, Ellen L., Puissant, Alexandre, Stone, Richard, Sattler, Martin, Buhrlage, Sara J., Yang, Jing, Manley, Paul W., Meng, Chengcheng, Buonopane, Michael, Daley, John F., Lazo, Suzan, Wright, Renee, Weinstock, David M., Christie, Amanda L., Stegmaier, Kimberly, Griffin, James D.
Publicado 2017

Selectively targeting FLT3-ITD mutants over FLT3- wt by a novel inhibitor for acute myeloid leukemia

por Wang, Aoli, Hu, Chen, Chen, Cheng, Liang, Xiaofei, Wang, Beilei, Zou, Fengming, Yu, Kailin, Li, Feng, Liu, Qingwang, Qi, Ziping, Wang, Junjie, Wang, Wenliang, Wang, Li, Weisberg, Ellen L., Wang, Wenchao, Li, Lili, Ge, Jian, Xia, Ruixiang, Liu, Jing, Liu, Qingsong
Publicado 2020

Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM)

por Lapidot, Moshe, Case, Abigail E., Larios, Dalia, Gandler, Helen I., Meng, Chengcheng, Tošić, Isidora, Weisberg, Ellen L., Poitras, Michael J., Gokhale, Prafulla C., Paweletz, Cloud P., Podar, Klaus, Salgia, Ravi, Saladi, Srinivas V., Griffin, James D., Frank, David A., Bueno, Raphael, Sattler, Martin
Publicado 2020

Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

por Wang, Aoli, Yan, Xiao-E, Wu, Hong, Wang, Wenchao, Hu, Chen, Chen, Cheng, Zhao, Zheng, Zhao, Peng, Li, Xixiang, Wang, Li, Wang, Beilei, Ye, Zi, Wang, Jinhua, Wang, Chu, Zhang, Wei, Gray, Nathanael S., Weisberg, Ellen L., Chen, Liang, Liu, Jing, Yun, Cai-Hong, Liu, Qingsong
Publicado 2016

Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML

por Wang, Aoli, Wu, Hong, Chen, Cheng, Hu, Chen, Qi, Ziping, Wang, Wenchao, Yu, Kailin, Liu, Xiaochuan, Zou, Fengming, Zhao, Zheng, Wu, Jiaxin, Liu, Juan, Liu, Feiyang, Wang, Li, Stone, Richard M., Galinksy, Ilene A., Griffin, James D., Zhang, Shanchun, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Publicado 2016

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

por Wu, Hong, Wang, Aoli, Zhang, Wei, Wang, Beilei, Chen, Cheng, Wang, Wenchao, Hu, Chen, Ye, Zi, Zhao, Zheng, Wang, Li, Li, Xixiang, Yu, Kailin, Liu, Juan, Wu, Jiaxin, Yan, Xiao-E, Zhao, Peng, Wang, Jinhua, Wang, Chu, Weisberg, Ellen L., Gray, Nathanael S., Yun, Cai-Hong, Liu, Jing, Chen, Liang, Liu, Qingsong
Publicado 2015

Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM)

por Lapidot, Moshe, Case, Abigail E., Weisberg, Ellen L., Meng, Chengcheng, Walker, Sarah R., Garg, Swati, Ni, Wei, Podar, Klaus, Hung, Yin P., Carrasco, Ruben D., Knott, Aine, Gokhale, Prafulla C., Sharma, Sunil, Pozhitkov, Alex, Kulkarni, Prakash, Frank, David A., Salgia, Ravi, Griffin, James D., Saladi, Srinivas V., Bueno, Raphael, Sattler, Martin
Publicado 2021

Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma

por Wu, Hong, Wang, Wenchao, Liu, Feiyang, Weisberg, Ellen L., Tian, Bei, Chen, Yongfei, Li, Binhua, Wang, Aoli, Wang, Beilei, Zhao, Zheng, McMillin, Douglas W., Hu, Chen, Li, Hong, Wang, Jinhua, Liang, Yanke, Buhrlage, Sara J., Liang, Junting, Liu, Jing, Yang, Guang, Brown, Jennifer R., Treon, Steven P., Mitsiades, Constantine S., Griffin, James D., Liu, Qingsong, Gray, Nathanael S.
Publicado 2014

Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances

por Liu, Xiaochuan, Wang, Aoli, Liang, Xiaofei, Chen, Cheng, Liu, Juanjuan, Zhao, Zheng, Wu, Hong, Deng, Yuanxin, Wang, Li, Wang, Beilei, Wu, Jiaxin, Liu, Feiyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Brown, Jennifer R., Griffin, James D., Zhang, Shanchun, Loh, Teckpeng, Zhang, Xin, Wang, Wenchao, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Publicado 2016

Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies

por Liu, Xiaochuan, Wang, Aoli, Liang, Xiaofei, Liu, Juanjuan, Zou, Fengming, Chen, Cheng, Zhao, Zheng, Deng, Yuanxin, Wu, Hong, Qi, Ziping, Wang, Beilei, Wang, Li, Liu, Feiyang, Xu, Yunhe, Wang, Wenchao, Fernandes, Stacey M., Stone, Richard M., Galinsky, Ilene A., Brown, Jennifer R., Loh, Teckpeng, Griffin, James. D., Zhang, Shanchun, Weisberg, Ellen L., Zhang, Xin, Liu, Jing, Liu, Qingsong
Publicado 2016

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

por Schauer, Nathan J., Liu, Xiaoxi, Magin, Robert S., Doherty, Laura M., Chan, Wai Cheung, Ficarro, Scott B., Hu, Wanyi, Roberts, Rebekka M., Iacob, Roxana E., Stolte, Björn, Giacomelli, Andrew O., Perera, Sumner, McKay, Kyle, Boswell, Sarah A., Weisberg, Ellen L., Ray, Arghya, Chauhan, Dharminder, Dhe-Paganon, Sirano, Anderson, Ken C., Griffin, James D., Li, Jianing, Hahn, William C., Sorger, Peter K., Engen, John R., Stegmaier, Kimberly, Marto, Jarrod A., Buhrlage, Sara J.
Publicado 2020