Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

por Kleinstiver, Benjamin P., Tsai, Shengdar Q., Prew, Michelle S., Nguyen, Nhu T., Welch, Moira M., Lopez, Jose M., McCaw, Zachary R., Aryee, Martin J., Joung, J. Keith
Publicado 2016

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

por Chen, Janice S., Dagdas, Yavuz S., Kleinstiver, Benjamin P., Welch, Moira M., Sousa, Alexander A., Harrington, Lucas B., Sternberg, Samuel H., Joung, J. Keith, Yildiz, Ahmet, Doudna, Jennifer A.
Publicado 2017

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

por Ando, Koji, Shah, Ankur K., Sachdev, Vibhu, Kleinstiver, Benjamin P., Taylor-Parker, Julian, Welch, Moira M., Hu, Yiheng, Salgia, Ravi, White, Forest M., Parvin, Jeffrey D., Ozonoff, Al, Rameh, Lucia E., Joung, J. Keith, Bharti, Ajit K.
Publicado 2017

Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

por Kleinstiver, Benjamin P., Sousa, Alexander A., Walton, Russell T., Tak, Y. Esther, Hsu, Jonathan Y., Clement, Kendell, Welch, Moira M., Horng, Joy E., Malagon-Lopez, Jose, Scarfò, Irene, Maus, Marcela V., Pinello, Luca, Aryee, Martin J., Joung, J. Keith
Publicado 2019