Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates

por Varga, Julia K., Diffley, Kelsey, Welker Leng, Katherine R., Fierke, Carol A., Schueler-Furman, Ora
Publicado 2022

BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program

por Kim, Dae-Hwan, Sun, Duanchen, Storck, William K., Welker Leng, Katherine, Jenkins, Chelsea, Coleman, Daniel J., Sampson, David, Guan, Xiangnan, Kumaraswamy, Anbarasu, Rodansky, Eva S., Urrutia, Joshua A., Schwartzman, Jacob A., Zhang, Chao, Beltran, Himisha, Labrecque, Mark P., Morrissey, Colm, Lucas, Jared M., Coleman, Ilsa M., Nelson, Peter S., Corey, Eva, Handelman, Samuel K., Sexton, Jonathan Z., Aggarwal, Rahul, Abida, Wassim, Feng, Felix Y., Small, Eric J., Spratt, Daniel E., Bankhead, Armand, Rao, Arvind, Gesner, Emily M., Attwell, Sarah, Lakhotia, Sanjay, Campeau, Eric, Yates, Joel A., Xia, Zheng, Alumkal, Joshi J.
Publicado 2021