Development of novel apoferritin formulations for antitumour benzothiazoles

por Breen, Alastair F., Wells, Geoffrey, Turyanska, Lyudmila, Bradshaw, Tracey D.
Publicado 2019

A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3)

por Shih, Po-Chang, Yang, Yiwen, Parkinson, Gary N., Wilderspin, Andrew, Wells, Geoffrey
Publicado 2018

The C‐terminal head domain of Burkholderia pseudomallei BpaC has a striking hydrophilic core with an extensive solvent network

por Kiessling, Andreas R., Harris, Sarah A., Weimer, Kathleen M., Wells, Geoffrey, Goldman, Adrian
Publicado 2022

Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

por König, Janine, Wyllie, Susan, Wells, Geoffrey, Stevens, Malcolm F., Wyatt, Paul G., Fairlamb, Alan H.
Publicado 2011

Induction of Tumor Cell Death through Targeting Tubulin and Evoking Dysregulation of Cell Cycle Regulatory Proteins by Multifunctional Cinnamaldehydes

por Nagle, Amrita A., Gan, Fei-Fei, Jones, Gavin, So, Choon-Leng, Wells, Geoffrey, Chew, Eng-Hui
Publicado 2012

Atomic force microscopy—A tool for structural and translational DNA research

por Main, Kavit H. S., Provan, James I., Haynes, Philip J., Wells, Geoffrey, Hartley, John A., Pyne, Alice L. B.
Publicado 2021

C2‐linked alkynyl poly‐ethylene glycol(PEG) adenosine conjugates as water‐soluble adenosine receptor agonists

por Ferguson, Lindsay, Madieh, Nasrin Shokrzadeh, Vaideanu, Alexandra, Schatzlein, Andreas, Festa, Joseph, Singh, Harprit, Wells, Geoffrey, Bhakta, Sanjib, Brucoli, Federico
Publicado 2022

Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery

por Breen, Alastair F, Scurr, David, Cassioli, Maria Letizia, Wells, Geoffrey, Thomas, Neil R, Zhang, Jihong, Turyanska, Lyudmila, Bradshaw, Tracey D
Publicado 2019

Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐Derived NRF2 Activators

por Mak, Kit‐Kay, Shiming, Zhang, Epemolu, Ola, Dinkova‐Kostova, Albena T., Wells, Geoffrey, Gazaryan, Irina G., Sakirolla, Raghavendra, Mohd, Zulkefeli, Pichika, Mallikarjuna Rao
Publicado 2022

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

por Kaminska, Kamila K., Bertrand, Helene C., Tajima, Hisashi, Stafford, William C., Cheng, Qing, Chen, Wan, Wells, Geoffrey, Arner, Elias S.J., Chew, Eng-Hui
Publicado 2016

The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding

por Gacesa, Ranko, Lawrence, Karl P., Georgakopoulos, Nikolaos D., Yabe, Kazuo, Dunlap, Walter C., Barlow, David J., Wells, Geoffrey, Young, Antony R., Long, Paul F.
Publicado 2018

Dose-escalated radiotherapy to 82 Gy for prostate cancer following insertion of a peri-rectal hydrogel spacer: 3-year outcomes from a phase II trial

por See, Andrew W., Bowden, Patrick, Wells, Geoffrey, Appu, Sree, Lawrentschuk, Nathan, Liodakis, Peter, Pandeli, Chloe, Aarons, Yolanda, Smyth, Lloyd M. L., McKenzie, Dean P.
Publicado 2022

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

por Horie, Yuta, Suzuki, Takafumi, Inoue, Jin, Iso, Tatsuro, Wells, Geoffrey, Moore, Terry W., Mizushima, Tsunehiro, Dinkova-Kostova, Albena T., Kasai, Takuma, Kamei, Takashi, Koshiba, Seizo, Yamamoto, Masayuki
Publicado 2021

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis

por Martín-Cámara, Olmo, Arribas, Marina, Wells, Geoffrey, Morales-Tenorio, Marcos, Martín-Requero, Ángeles, Porras, Gracia, Martínez, Ana, Giorgi, Giorgio, López-Alvarado, Pilar, Lastres-Becker, Isabel, Menéndez, J. Carlos
Publicado 2022

Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode

por Georgakopoulos, Nikolaos, Talapatra, Sandeep, Dikovskaya, Dina, Dayalan Naidu, Sharadha, Higgins, Maureen, Gatliff, Jemma, Ayhan, Aysel, Nikoloudaki, Roxani, Schaap, Marjolein, Valko, Klara, Javid, Farideh, Dinkova-Kostova, Albena T., Kozielski, Frank, Wells, Geoffrey
Publicado 2022

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease

por Gameiro, Isabel, Michalska, Patrycja, Tenti, Giammarco, Cores, Ángel, Buendia, Izaskun, Rojo, Ana I., Georgakopoulos, Nikolaos D., Hernández-Guijo, Jesús M., Teresa Ramos, María, Wells, Geoffrey, López, Manuela G., Cuadrado, Antonio, Menéndez, J. Carlos, León, Rafael
Publicado 2017

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

por Kerr, Fiona, Sofola-Adesakin, Oyinkan, Ivanov, Dobril K., Gatliff, Jemma, Gomez Perez-Nievas, Beatriz, Bertrand, Hélène C., Martinez, Pedro, Callard, Rebecca, Snoeren, Inge, Cochemé, Helena M., Adcott, Jennifer, Khericha, Mobina, Castillo-Quan, Jorge Iván, Wells, Geoffrey, Noble, Wendy, Thornton, Janet, Partridge, Linda
Publicado 2017