Arming NK cells with enhanced antitumor activity: CARs and beyond

por Oberoi, Pranav, Wels, Winfried S
Publicado 2013

Innate-like NKp30(+)CD8(+) T cells armed with TCR/CAR target tumor heterogeneity

por Correia, Margareta P., Stojanovic, Ana, Wels, Winfried S., Cerwenka, Adelheid
Publicado 2021

EGFR-Targeted Granzyme B Expressed in NK Cells Enhances Natural Cytotoxicity and Mediates Specific Killing of Tumor Cells

por Oberoi, Pranav, Jabulowsky, Robert A., Bähr-Mahmud, Hayat, Wels, Winfried S.
Publicado 2013

Maltose-Binding Protein Enhances Secretion of Recombinant Human Granzyme B Accompanied by In Vivo Processing of a Precursor MBP Fusion Protein

por Dälken, Benjamin, Jabulowsky, Robert A., Oberoi, Pranav, Benhar, Itai, Wels, Winfried S.
Publicado 2010

Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity

por Zhang, Congcong, Oberoi, Pranav, Oelsner, Sarah, Waldmann, Anja, Lindner, Aline, Tonn, Torsten, Wels, Winfried S.
Publicado 2017

Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK Cells with Enhanced Antitumor Activity

por Oberoi, Pranav, Kamenjarin, Kathrina, Villena Ossa, Jose Francisco, Uherek, Barbara, Bönig, Halvard, Wels, Winfried S.
Publicado 2020

Vaccination Directed against the Human Endogenous Retrovirus-K Envelope Protein Inhibits Tumor Growth in a Murine Model System

por Kraus, Benjamin, Fischer, Katrin, Büchner, Sarah M., Wels, Winfried S., Löwer, Roswitha, Sliva, Katja, Schnierle, Barbara S.
Publicado 2013

Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting

por Eitler, Jiri, Wotschel, Natalie, Miller, Nicole, Boissel, Laurent, Klingemann, Hans G, Wels, Winfried, Tonn, Torsten
Publicado 2021

Generation and characterization of ErbB2-CAR-engineered cytokine-induced killer cells for the treatment of high-risk soft tissue sarcoma in children

por Merker, Michael, Pfirrmann, Verena, Oelsner, Sarah, Fulda, Simone, Klingebiel, Thomas, Wels, Winfried S., Bader, Peter, Rettinger, Eva
Publicado 2017

Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody-dependent cellular cytotoxicity

por Boissel, Laurent, Betancur-Boissel, Monica, Lu, Weiquan, Krause, Daniela S, Van Etten, Richard A, Wels, Winfried S, Klingemann, Hans
Publicado 2013

CD19‐CAR engineered NK‐92 cells are sufficient to overcome NK cell resistance in B‐cell malignancies

por Romanski, Annette, Uherek, Christoph, Bug, Gesine, Seifried, Erhard, Klingemann, Hans, Wels, Winfried S., Ottmann, Oliver G., Tonn, Torsten
Publicado 2016

ErbB2/Her2-specific NK cells for adoptive immunotherapy of glioblastoma

por Zhang, Congcong, Burger, Michael, Jennewein, Lukas, Genßler, Sabrina, Grez, Manuel, Tonn, Torsten, Mittelbronn, Michel, Steinbach, Joachim, Wels, Winfried
Publicado 2014

Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD(2)-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2

por Bodden, Malena, Häcker, Aline, Röder, Jasmin, Kiefer, Anne, Zhang, Congcong, Bhatti, Anita, Pfeifer Serrahima, Jordi, Ullrich, Evelyn, Kühnel, Ines, Wels, Winfried S.
Publicado 2023

Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer

por Murali Shankar, Nivedha, Ortiz-Montero, Paola, Kurzyukova, Anastasia, Rackwitz, Wiebke, Künzel, Stephan R., Wels, Winfried S., Tonn, Torsten, Knopf, Franziska, Eitler, Jiri
Publicado 2023

Advantages and applications of CAR-expressing natural killer cells

por Glienke, Wolfgang, Esser, Ruth, Priesner, Christoph, Suerth, Julia D., Schambach, Axel, Wels, Winfried S., Grez, Manuel, Kloess, Stephan, Arseniev, Lubomir, Koehl, Ulrike
Publicado 2015

CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy

por Burger, Michael C., Zhang, Congcong, Harter, Patrick N., Romanski, Annette, Strassheimer, Florian, Senft, Christian, Tonn, Torsten, Steinbach, Joachim P., Wels, Winfried S.
Publicado 2019

Expression of Potential Targets for Cell-Based Therapies on Melanoma Cells

por Strobel, Sophia B., Machiraju, Devayani, Hülsmeyer, Ingrid, Becker, Jürgen C., Paschen, Annette, Jäger, Dirk, Wels, Winfried S., Bachmann, Michael, Hassel, Jessica C.
Publicado 2021

Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity

por Zhang, Congcong, Röder, Jasmin, Scherer, Anne, Bodden, Malena, Pfeifer Serrahima, Jordi, Bhatti, Anita, Waldmann, Anja, Müller, Nina, Oberoi, Pranav, Wels, Winfried S
Publicado 2021

High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia

por Müller, Stephan, Bexte, Tobias, Gebel, Veronika, Kalensee, Franziska, Stolzenberg, Eva, Hartmann, Jessica, Koehl, Ulrike, Schambach, Axel, Wels, Winfried S., Modlich, Ute, Ullrich, Evelyn
Publicado 2020

PB1715: UNLEASHING NATURAL KILLER (NK) CELLS TO PROMOTE ANTI-LEUKEMIC IMMUNITY

por Tsoukala, Ioanna, Schäffer, Alexander, Tirado-Gonzalez, Irene, Röder, Jasmin, Serrahima, Jordi Pfeifer, Mosa, Mohammed H., Seotopo, Devona, Descot, Arnaud, Wels, Winfried S., Medyouf, Hind
Publicado 2023