New Insights into Ion Channels: Predicting hERG-Drug Interactions

por Wempe, Michael Fitzpatrick
Publicado 2022

JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells

por Choi, Dae Woo, Kim, Do Kyung, Kanai, Yoshikatsu, Wempe, Michael F., Endou, Hitoshi, Kim, Jong-Keun
Publicado 2017

Metformin does not slow cyst growth in the PCK rat model of polycystic kidney disease

por Oto, Ozgur A., Atwood, Daniel J., Chaudhary, Anjana, He, Zhibin, Li, Amy S., Wempe, Michael F., Edelstein, Charles L.
Publicado 2023

Comparative Pre-clinical Efficacy of Chinese and Indian Cultivars of Bitter Melon (Momordica charantia) against Pancreatic Cancer

por Kandhari, Kushal, Paudel, Sandeep, Raina, Komal, Agarwal, Chapla, Kant, Rama, Wempe, Michael F., O’Bryant, Cindy, Agarwal, Rajesh
Publicado 2021

Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy

por Kiser, Tyree H, Fish, Douglas N, Aquilante, Christina L, Rower, Joseph E, Wempe, Michael F, MacLaren, Robert, Teitelbaum, Isaac
Publicado 2015

EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses

por Ravindran Menon, Dinoop, Li, Yang, Yamauchi, Takeshi, Osborne, Douglas Grant, Vaddi, Prasanna Kumar, Wempe, Michael F, Zhai, Zili, Fujita, Mayumi
Publicado 2021

Retraction: Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed In Utero to Di(n-butyl) Phthalate

por Wakui, Shin, Motohashi, Masaya, Satoh, Takemi, Shirai, Masaru, Mutou, Tomoko, Takahashi, Hiroyuki, Wempe, Michael F., Endou, Hitoshi, Inomata, Tomoo, Asari, Masao
Publicado 2023

Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed In Utero to Di(n-butyl) Phthalate

por Wakui, Shin, Motohashi, Masaya, Satoh, Takemi, Shirai, Masaru, Mutou, Tomoko, Takahashi, Hiroyuki, Wempe, Michael F., Endou, Hitoshi, Inomata, Tomoo, Asari, Masao
Publicado 2013

Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies

por Wempe, Michael F, Lightner, Janet W, Miller, Bettina, Iwen, Timothy J, Rice, Peter J, Wakui, Shin, Anzai, Naohiko, Jutabha, Promsuk, Endou, Hitoshi
Publicado 2012

Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma

por Cormerais, Yann, Pagnuzzi‐Boncompagni, Marina, Schrötter, Sandra, Giuliano, Sandy, Tambutté, Eric, Endou, Hitoshi, Wempe, Michael F., Pagès, Gilles, Pouysségur, Jacques, Picco, Vincent
Publicado 2019

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

por Cormerais, Yann, Massard, Pierre André, Vucetic, Milica, Giuliano, Sandy, Tambutté, Eric, Durivault, Jerome, Vial, Valérie, Endou, Hitoshi, Wempe, Michael F., Parks, Scott K., Pouyssegur, Jacques
Publicado 2018

New Insights into the Structure of (1→3,1→6)-β-D-Glucan Side Chains in the Candida glabrata Cell Wall

por Lowman, Douglas W., West, Lara J., Bearden, Daniel W., Wempe, Michael F., Power, Trevor D., Ensley, Harry E., Haynes, Ken, Williams, David L., Kruppa, Michael D.
Publicado 2011

SURG-05. MRI-GUIDED FOCUSED ULTRASOUND BLOOD-BRAIN BARRIER DISRUPTION INCREASES DRUG DELIVERY AND EFFICACY IN AN ORTHOTOPIC DIPG MODEL

por Martinez, Payton, Nault, Genna, Steiner, Jenna, Wempe, Michael, Pierce, Angela, Brunt, Breaunna, Slade, Mathew, Mongin, Andrew, Song, Jane, Song, Kang-Ho, Ellens, Nicholas, Serkova, Natalie, Green, Adam, Borden, Mark
Publicado 2023

Transcriptome and metabolome changes induced by bitter melon (Momordica charantia)- intake in a high-fat diet induced obesity model

por Reed, Dominique, Kumar, Dileep, Kumar, Sushil, Raina, Komal, Punia, Reenu, Kant, Rama, Saba, Laura, Cruickshank-Quinn, Charmion, Tabakoff, Boris, Reisdorph, Nichole, Edwards, Michael G., Wempe, Michael, Agarwal, Chapla, Agarwal, Rajesh
Publicado 2021

MRI-guided focused ultrasound blood–brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model

por Martinez, Payton, Nault, Genna, Steiner, Jenna, Wempe, Michael F, Pierce, Angela, Brunt, Breauna, Slade, Mathew, Song, Jane J, Mongin, Andrew, Song, Kang-Ho, Ellens, Nicholas, Serkova, Natalie, Green, Adam L, Borden, Mark
Publicado 2023

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

por Andres-Hernando, Ana, Li, Nanxing, Cicerchi, Christina, Inaba, Shinichiro, Chen, Wei, Roncal-Jimenez, Carlos, Le, Myphuong T., Wempe, Michael F., Milagres, Tamara, Ishimoto, Takuji, Fini, Mehdi, Nakagawa, Takahiko, Johnson, Richard J., Lanaspa, Miguel A.
Publicado 2017

Liver X Receptor Activation with an Intranasal Polymer Therapeutic Prevents Cognitive Decline without Altering Lipid Levels

por Navas Guimaraes, María Eugenia, Lopez-Blanco, Roi, Correa, Juan, Fernandez-Villamarin, Marcos, Bistué, María Beatriz, Martino-Adami, Pamela, Morelli, Laura, Kumar, Vijay, Wempe, Michael F., Cuello, A. C., Fernandez-Megia, Eduardo, Bruno, Martin A.
Publicado 2021

Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization

por Boakye, Adjoa A., Zhang, Deqing, Guo, Luping, Zheng, Yuting, Hoetker, David, Zhao, Jingjing, Posa, Dheeraj Kumar, Ng, Chin K., Zheng, Huaiyu, Kumar, Amit, Kumar, Vijay, Wempe, Michael F., Bhatnagar, Aruni, Conklin, Daniel J., Baba, Shahid P.
Publicado 2019

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

por Koneru, Pratibha C, Francis, Ashwanth C, Deng, Nanjie, Rebensburg, Stephanie V, Hoyte, Ashley C, Lindenberger, Jared, Adu-Ampratwum, Daniel, Larue, Ross C, Wempe, Michael F, Engelman, Alan N, Lyumkis, Dmitry, Fuchs, James R, Levy, Ronald M, Melikyan, Gregory B, Kvaratskhelia, Mamuka
Publicado 2019

Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury

por Zhao, Jingjing, Conklin, Daniel J., Guo, Yiru, Zhang, Xiang, Obal, Detlef, Guo, Luping, Jagatheesan, Ganapathy, Katragadda, Kartik, He, Liqing, Yin, Xinmin, Prodhan, Md Aminul Islam, Shah, Jasmit, Hoetker, David, Kumar, Amit, Kumar, Vijay, Wempe, Michael F., Bhatnagar, Aruni, Baba, Shahid P.
Publicado 2020