Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis

por Lee, Chehao, Xin, Guang, Li, Fan, Wan, Chengyu, Yu, Xiuxian, Feng, Lijuan, Wen, Ao, Cao, Yu, Huang, Wen
Publicado 2023

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy A...

por Lin, Sheng, Chen, Zimin, Zhang, Xindan, Wen, Ao, Yuan, Xin, Yu, Chongzhang, Yang, Jing, He, Bin, Cao, Yu, Lu, Guangwen
Publicado 2022

NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation

por Zhou, Xiaoli, Yu, Xiuxian, Wan, Chengyu, Li, Fan, Wang, Yilan, Zhang, Kun, Feng, Lijuan, Wen, Ao, Deng, Jiangrong, Li, Shiyi, Xin, Guang, Huang, Wen
Publicado 2023

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity

por Lin, Sheng, Chen, Hua, Chen, Zimin, Yang, Fanli, Ye, Fei, Zheng, Yue, Yang, Jing, Lin, Xi, Sun, Honglu, Wang, Lingling, Wen, Ao, Dong, Haohao, Xiao, Qingjie, Deng, Dong, Cao, Yu, Lu, Guangwen
Publicado 2021

A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding

por Yang, Jing, Lin, Sheng, Sun, Honglu, Chen, Zimin, Yang, Fanli, Lin, Xi, Guo, Liyan, Wang, Lingling, Wen, Ao, Zhang, Xindan, Dai, Yushan, He, Bin, Cao, Yu, Dong, Haohao, Liu, Xianbo, Chen, Bo, Li, Jian, Zhao, Qi, Lu, Guangwen
Publicado 2022

An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry

por Lin, Xi, Guo, Liyan, Lin, Sheng, Chen, Zimin, Yang, Fanli, Yang, Jing, Wang, Lingling, Wen, Ao, Duan, Yanping, Zhang, Xindan, Dai, Yushan, Yin, Keqing, Yuan, Xin, Yu, Chongzhang, He, Bin, Cao, Yu, Dong, Haohao, Li, Jian, Zhao, Qi, Lu, Guangwen
Publicado 2022

Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor

por Yue, Dan, Chen, Zhujun, Yang, Fanli, Ye, Fei, Lin, Sheng, He, Bin, Cheng, Yanwei, Wang, Jichao, Chen, Zimin, Lin, Xi, Yang, Jing, Chen, Hua, Zhang, Zhonglin, You, Yu, Sun, Honglu, Wen, Ao, Wang, Lingling, Zheng, Yue, Cao, Yu, Li, Yuhua, Lu, Guangwen
Publicado 2020

S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

por Ye, Fei, Lin, Xi, Chen, Zimin, Yang, Fanli, Lin, Sheng, Yang, Jing, Chen, Hua, Sun, Honglu, Wang, Lingling, Wen, Ao, Zhang, Xindan, Dai, Yushan, Cao, Yu, Yang, Jingyun, Shen, Guobo, Yang, Li, Li, Jiong, Wang, Zhenling, Wang, Wei, Wei, Xiawei, Lu, Guangwen
Publicado 2021

Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruse...

por Chen, Hua, Lin, Sheng, Yang, Fanli, Chen, Zimin, Guo, Liyan, Yang, Jing, Lin, Xi, Wang, Lingling, Duan, Yanping, Wen, Ao, Zhang, Xindan, Dai, Yushan, Yin, Keqing, Yuan, Xin, Yu, Chongzhang, He, Yarong, He, Bin, Cao, Yu, Dong, Haohao, Li, Jian, Zhao, Qi, Liu, Quan, Lu, Guangwen
Publicado 2023