Expansion of Bone Precursors through Jun as a Novel Treatment for Osteoporosis-Associated Fractures

por Lerbs, Tristan, Cui, Lu, Muscat, Claire, Saleem, Atif, van Neste, Camille, Domizi, Pablo, Chan, Charles, Wernig, Gerlinde
Publicado 2020

CD47 prevents the elimination of diseased fibroblasts in scleroderma

por Lerbs, Tristan, Cui, Lu, King, Megan E., Chai, Tim, Muscat, Claire, Chung, Lorinda, Brown, Ryanne, Rieger, Kerri, Shibata, Tyler, Wernig, Gerlinde
Publicado 2020

Innate immune cell activation causes lung fibrosis in a humanized model of long COVID

por Cui, Lu, Fang, Zhuoqing, De Souza, Cristabelle Madona, Lerbs, Tristan, Guan, Yuan, Li, Irene, Charu, Vivek, Chen, Shih-Yu, Weissman, Irving, Wernig, Gerlinde
Publicado 2023

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

por Cui, Lu, Chen, Shih-Yu, Lerbs, Tristan, Lee, Jin-Wook, Domizi, Pablo, Gordon, Sydney, Kim, Yong-hun, Nolan, Garry, Betancur, Paola, Wernig, Gerlinde
Publicado 2020

Abstract 85: Jun Drives A Fibrogenic Cutaneous Wound Healing Response Through Differential Action On Distinct Fibroblast Subpopulations

por Borrelli, Mimi R., Moore, Alexandra L., Maschara, Shamik, Duoto, Bryan A., desJardens-Park, Heather E., Patel, Ronak A., Sokol, Jan, Wan, Derrick C., Wernig, Gerlinde, Longaker, Michael T.
Publicado 2019

Abstract 45: Beyond Antibiotics: Local Doxycycline Administration Reduces Scarring and Improves Wound Healing by Modulating Scarring Fibroblast Behavior

por desJardins-Park, Heather E., Moore, Alessandra L., Murphy, Matthew P., Irizarry, Dre, Duoto, Bryan, Foster, Deshka, Jones, Ruth Ellen, Mascharak, Shamik, Barnes, Leandra, Marshall, Clement, Wernig, Gerlinde, Longaker, Michael T.
Publicado 2018

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

por Czechowicz, Agnieszka, Palchaudhuri, Rahul, Scheck, Amelia, Hu, Yu, Hoggatt, Jonathan, Saez, Borja, Pang, Wendy W., Mansour, Michael K., Tate, Tiffany A., Chan, Yan Yi, Walck, Emily, Wernig, Gerlinde, Shizuru, Judith A., Winau, Florian, Scadden, David T., Rossi, Derrick J.
Publicado 2019

Abstract 189: Postnatal Engrailed-1 Expression Activates A Pro-Fibrotic Transcriptional Program In Wound Fibroblasts

por Mascharak, Shamik, desJardins-Park, Heather E., Borrelli, Mimi R., Moore, Alessandra L., Davitt, Michael F., Chinta, Malini, Foster, Deshka S., Januszyk, Michael, Kwon, Sun Hyung, Wernig, Gerlinde, Wan, Derrick C., Lorenz, H Peter, Gurtner, Geoffrey C., Longaker, MIchael T.
Publicado 2020

Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

por Cui, Lu, Moraga, Ignacio, Lerbs, Tristan, Van Neste, Camille, Wilmes, Stephan, Tsutsumi, Naotaka, Trotman-Grant, Aaron Claudius, Gakovic, Milica, Andrews, Sarah, Gotlib, Jason, Darmanis, Spyros, Enge, Martin, Quake, Stephen, Hitchcock, Ian S., Piehler, Jacob, Garcia, K. Christopher, Wernig, Gerlinde
Publicado 2021

MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

por Pikman, Yana, Lee, Benjamin H, Mercher, Thomas, McDowell, Elizabeth, Ebert, Benjamin L, Gozo, Maricel, Cuker, Adam, Wernig, Gerlinde, Moore, Sandra, Galinsky, Ilene, DeAngelo, Daniel J, Clark, Jennifer J, Lee, Stephanie J, Golub, Todd R, Wadleigh, Martha, Gilliland, D. Gary, Levine, Ross L
Publicado 2006

Abstract 190: Dermal Wounding Reveals Focal Adhesion Kinase Dependent Tissue-Resident Fibroblast Progenitors

por Chinta, Malini, Foster, Deshka, Nguyen, Alan, Salhotra, Ankit, Gulati, Gunsagar, Chase Ransom, R., Ellen Jones, R., Titan, Ashley L., Marshall, Clement D., Mascharak, Shamik, Hu, Michael, Januszyk, Michael, Gurtner, Geoffrey C., Wan, Derrick C., Norton, Jeffrey A., Chang, Howard Y., Wernig, Gerlinde, Longaker, Michael T.
Publicado 2020

Abstract 186: CD36 Antagonism Minimizes Skin Scarring By Inhibiting JUN-dependent Fibrotic Pathways Within Fibrogenic Fibroblast Subpopulations

por Borrelli, Mimi R., Garcia, Julia, Griffin, Michelle, Deleon Diaz, Nestor M., Moore, Alexandra L., Mascharak, Shamik, Duoto, Bryan, desJardins-Park, Heather, Adem, Sandeep, Lerbs, Tristan, Gastou, Marc, Cui, Lui, Januszyk, Michael, Lorenz, Hermann P., Wan, Derrick C., Gurtner, Geoffrey C., Chang, Howard, Wernig, Gerlinde, Longaker, Michael T.
Publicado 2020

Wound Healing Myofibroblasts Proliferate Clonally and in a Mechanoresponsive Manner

por Chinta, Malini, Foster, Deshka, Nguyen, Alan T., Salhotra, Ankit, Gulati, Gunsagar, Ransom, Chase, Mascharak, Shamik, Jones, R. Ellen, Titan, Ashley L., Marshall, Clement D., Hu, Michael, desJardins-Park, Heather E., Januszyk, Michael, Gurtner, Geoffrey, Wan, Derrick C., Norton, Jeffrey A., Chang, Howard Y., Wernig, Gerlinde, Longaker, Michael T.
Publicado 2020

Elucidating the fundamental fibrotic processes driving abdominal adhesion formation

por Foster, Deshka S., Marshall, Clement D., Gulati, Gunsagar S., Chinta, Malini S., Nguyen, Alan, Salhotra, Ankit, Jones, R. Ellen, Burcham, Austin, Lerbs, Tristan, Cui, Lu, King, Megan E., Titan, Ashley L., Ransom, R. Chase, Manjunath, Anoop, Hu, Michael S., Blackshear, Charles P., Mascharak, Shamik, Moore, Alessandra L., Norton, Jeffrey A., Kin, Cindy J., Shelton, Andrew A., Januszyk, Michael, Gurtner, Geoffrey C., Wernig, Gerlinde, Longaker, Michael T.
Publicado 2020

Upregulation of PD‐L1 by SARS‐CoV‐2 promotes immune evasion

por Huang, Hsiang‐Chi, Wang, Shih‐Han, Fang, Guo‐Chen, Chou, Wen‐Cheng, Liao, Chun‐Che, Sun, Cheng‐Pu, Jan, Jia‐Tsrong, Ma, Hsiu‐Hua, Ko, Hui‐Ying, Ko, Yi‐An, Chiang, Ming‐Tsai, Liang, Jian‐Jong, Kuo, Chun‐Tse, Lee, Te‐An, Morales‐Scheihing, Diego, Shen, Chen‐Yang, Chen, Shih‐Yu, McCullough, Louise D., Cui, Lu, Wernig, Gerlinde, Tao, Mi‐Hua, Lin, Yi‐Ling, Chang, Yao‐Ming, Wang, Shu‐Ping, Lai, Yun‐Ju, Li, Chia‐Wei
Publicado 2023

Integrated spatial multiomics reveals fibroblast fate during tissue repair

por Foster, Deshka S., Januszyk, Michael, Yost, Kathryn E., Chinta, Malini S., Gulati, Gunsagar S., Nguyen, Alan T., Burcham, Austin R., Salhotra, Ankit, Ransom, R. Chase, Henn, Dominic, Chen, Kellen, Mascharak, Shamik, Tolentino, Karen, Titan, Ashley L., Jones, R. Ellen, da Silva, Oscar, Leavitt, W. Tripp, Marshall, Clement D., des Jardins-Park, Heather E., Hu, Michael S., Wan, Derrick C., Wernig, Gerlinde, Wagh, Dhananjay, Coller, John, Norton, Jeffrey A., Gurtner, Geoffrey C., Newman, Aaron M., Chang, Howard Y., Longaker, Michael T.
Publicado 2021