PBPK modeling of ivermectin—Considerations for the purpose of developing alternative routes to optimize its safety profile

por Rowland Yeo, Karen, Wesche, David
Publicado 2023

Optimizing COVID‐19 Candidate Therapeutics: Thinking Without Borders

por Rayner, Craig R., Smith, Patrick F., Hershberger, Kevin, Wesche, David
Publicado 2020

Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy

por Tolbert, Dwain, Cloyd, James, Biton, Victor, Bekersky, Ihor, Walzer, Mark, Wesche, David, Drummond, Rebecca, Lee, Deborah
Publicado 2015

Model‐Informed Assessment of Anti‐Infectives for Young Children in Low‐ and Middle‐Income Countries

por Zhao, Ping, Arm, Jonathan, Ma, Lyou‐Fu, Ward, Stephen, Hermann, David, Wesche, David, Hartman, Dan, Kern, Steven
Publicado 2019

Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

por Rowland Yeo, Karen, Zhang, Mian, Pan, Xian, Ban Ke, Alice, Jones, Hannah M., Wesche, David, Almond, Lisa M.
Publicado 2020

Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial...

por Andrews, Kayla Ann, Owen, Joel S., McCarthy, James, Wesche, David, Gobeau, Nathalie, Grasela, Thaddeus H., Möhrle, Jörg J.
Publicado 2020

Model-Informed Drug Development for Malaria Therapeutics

por Andrews, Kayla Ann, Wesche, David, McCarthy, James, Möhrle, Jörg J., Tarning, Joel, Phillips, Luann, Kern, Steven, Grasela, Thaddeus
Publicado 2017

Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus d...

por Barnabas, Ruanne V., Brown, Elizabeth, Bershteyn, Anna, Miller, R. Scott, Wener, Mark, Celum, Connie, Wald, Anna, Chu, Helen, Wesche, David, Baeten, Jared M.
Publicado 2020

Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19

por Rayner, Craig R., Dron, Louis, Park, Jay J. H., Decloedt, Eric H., Cotton, Mark F., Niranjan, Vis, Smith, Patrick F., Dodds, Michael G., Brown, Fran, Reis, Gilmar, Wesche, David, Mills, Edward J.
Publicado 2020

Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa...

por Onyamboko, Marie A, Meshnick, Steven R, Fleckenstein, Lawrence, Koch, Matthew A, Atibu, Joseph, Lokomba, Victor, Douoguih, Macaya, Hemingway-Foday, Jennifer, Wesche, David, Ryder, Robert W, Bose, Carl, Wright, Linda L, Tshefu, Antoinette K, Capparelli, Edmund V
Publicado 2011

Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria

por Morris, Carrie A, Onyamboko, Marie A, Capparelli, Edmund, Koch, Matthew A, Atibu, Joseph, Lokomba, Vicky, Douoguih, Macaya, Hemingway-Foday, Jennifer, Wesche, David, Ryder, Robert W, Bose, Carl, Wright, Linda, Tshefu, Antoinette K, Meshnick, Steven, Fleckenstein, Lawrence
Publicado 2011

Characterizing the Blood-Stage Antimalarial Activity of Tafenoquine in Healthy Volunteers Experimentally Infected With Plasmodium falciparum

por Barber, Bridget E, Abd-Rahman, Azrin N, Webster, Rebecca, Potter, Adam J, Llewellyn, Stacey, Marquart, Louise, Sahai, Nischal, Leelasena, Indika, Birrell, Geoffrey W, Edstein, Michael D, Shanks, G Dennis, Wesche, David, Moehrle, Joerg J, McCarthy, James S
Publicado 2023

Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future

por Rayner, Craig R., Smith, Patrick F., Andes, David, Andrews, Kayla, Derendorf, Hartmut, Friberg, Lena E., Hanna, Debra, Lepak, Alex, Mills, Edward, Polasek, Thomas M., Roberts, Jason A., Schuck, Virna, Shelton, Mark J., Wesche, David, Rowland‐Yeo, Karen
Publicado 2021

Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria

por Baird, J. Kevin, Louisa, Melva, Noviyanti, Rintis, Ekawati, Lenny, Elyazar, Iqbal, Subekti, Decy, Chand, Krisin, Gayatri, Anggi, Instiaty, Soebianto, Saraswati, Crenna-Darusallam, Chelzie, Djoko, Dwi, Hasto, Bambang Dwi, Meriyenes, Dubel, Wesche, David, Nelwan, Erni J., Sutanto, Inge, Sudoyo, Herawati, Setiabudy, Rianto
Publicado 2018

Development and application of a PBPK modeling strategy to support antimalarial drug development

por Abla, Nada, Howgate, Eleanor, Rowland‐Yeo, Karen, Dickins, Maurice, Bergagnini‐Kolev, Mackenzie C., Chen, Kuan‐Fu, McFeely, Savannah, Bonner, Jennifer J., Santos, Laura G. A., Gobeau, Nathalie, Burt, Howard, Barter, Zoe, Jones, Hannah M., Wesche, David, Charman, Susan A., Möhrle, Jörg J., Burrows, Jeremy N., Almond, Lisa M.
Publicado 2023

Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data

por Chan, Xin Hui S., Win, Yan Naung, Haeusler, Ilsa L., Tan, Jireh Y., Loganathan, Shanghavie, Saralamba, Sompob, Chan, Shu Kiat S., Ashley, Elizabeth A., Barnes, Karen I., Baiden, Rita, Bassi, Peter U., Djimde, Abdoulaye, Dorsey, Grant, Duparc, Stephan, Hanboonkunupakarn, Borimas, ter Kuile, Feiko O., Lacerda, Marcus V. G., Nasa, Amit, Nosten, François H., Onyeji, Cyprian O., Pukrittayakamee, Sasithon, Siqueira, André M., Tarning, Joel, Taylor, Walter R. J., Valentini, Giovanni, van Vugt, Michèle, Wesche, David, Day, Nicholas P. J., Huang, Christopher L-H, Brugada, Josep, Price, Ric N., White, Nicholas J.
Publicado 2020