Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

por Suparmi, Suparmi, Wesseling, Sebastiaan, Rietjens, Ivonne M. C. M.
Publicado 2020

Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

por Widjaja, Frances, Wesseling, Sebastiaan, Rietjens, Ivonne M. C. M.
Publicado 2021

Aflatoxin B1 in nixtamalized maize in Mexico; occurrence and accompanying risk assessment

por Gilbert Sandoval, Ixchel, Wesseling, Sebastiaan, Rietjens, Ivonne M.C.M.
Publicado 2019

Predicting the Acute Liver Toxicity of Aflatoxin B1 in Rats and Humans by an In Vitro–In Silico Testing Strategy

por Gilbert‐Sandoval, Ixchel, Wesseling, Sebastiaan, Rietjens, Ivonne M. C. M.
Publicado 2020

Occurrence and Probabilistic Risk Assessment of Fumonisin B1, Fumonisin B2 and Deoxynivalenol in Nixtamalized Maize in Mexico City

por Gilbert-Sandoval, Ixchel, Wesseling, Sebastiaan, Rietjens, Ivonne M. C. M.
Publicado 2020

Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of py...

por Widjaja, Frances, Zheng, Liang, Wesseling, Sebastiaan, Rietjens, Ivonne M. C. M.
Publicado 2023

Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

por Zhao, Shensheng, Wesseling, Sebastiaan, Spenkelink, Bert, Rietjens, Ivonne M. C. M.
Publicado 2021

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supers...

por Zhao, Shensheng, Wesseling, Sebastiaan, Rietjens, Ivonne. M. C. M., Strikwold, Marije
Publicado 2022

Consequences of perinatal treatment with l-arginine and antioxidants for the renal transcriptome in spontaneously hypertensive rats

por Wesseling, Sebastiaan, Koeners, Maarten P., Kantouh, Farid, Joles, Jaap A., Braam, Branko
Publicado 2009

On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin

por Ren, Qiuhui, Bakker, Wouter, Wesseling, Sebastiaan, Bouwmeester, Hans, Rietjens, Ivonne M. C. M.
Publicado 2023

Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling

por Ning, Jia, Louisse, Jochem, Spenkelink, Bert, Wesseling, Sebastiaan, Rietjens, Ivonne M. C. M.
Publicado 2017

Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants

por van Dongen, Katja C W, Ioannou, Athanasia, Wesseling, Sebastiaan, Beekmann, Karsten, Belzer, Clara
Publicado 2022

Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Cau...

por Zhao, Shensheng, Kamelia, Lenny, Boonpawa, Rungnapa, Wesseling, Sebastiaan, Spenkelink, Bert, Rietjens, Ivonne M C M
Publicado 2019

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling appro...

por Abdullah, Rozaini, Wesseling, Sebastiaan, Spenkelink, Bert, Louisse, Jochem, Punt, Ans, Rietjens, Ivonne M.C.M.
Publicado 2020

Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans

por Chen, Jiaqi, Noorlander, Annelies, Wesseling, Sebastiaan, Bouwmeester, Hans, Kramer, Nynke I., Rietjens, Ivonne M.C.M.
Publicado 2023

Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto

por Al-Malahmeh, Amer J., Al-ajlouni, Abdalmajeed M., Wesseling, Sebastiaan, Vervoort, Jacques, Rietjens, Ivonne M.C.M.
Publicado 2016

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

por Hiben, Mebrahtom Gebrelibanos, de Haan, Laura, Spenkelink, Bert, Wesseling, Sebastiaan, Vervoort, Jacques, Rietjens, Ivonne M. C. M.
Publicado 2020

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

por Yang, Shuo, Diem, Matthias, Liu, Jakob D. H., Wesseling, Sebastiaan, Vervoort, Jacques, Oostenbrink, Chris, Rietjens, Ivonne M. C. M.
Publicado 2020

Perinatal Exogenous Nitric Oxide in Fawn-Hooded Hypertensive Rats Reduces Renal Ribosomal Biogenesis in Early Life

por Wesseling, Sebastiaan, Essers, Paul B., Koeners, Maarten P., Pereboom, Tamara C., Braam, Branko, van Faassen, Ernst E., MacInnes, Alyson W., Joles, Jaap A.
Publicado 2011

Physiologically based kinetic modeling of the bioactivation of myristicin

por Al-Malahmeh, Amer J., Al-Ajlouni, Abdelmajeed, Wesseling, Sebastiaan, Soffers, Ans E. M. F., Al-Subeihi, Ala’, Kiwamoto, Reiko, Vervoort, Jacques, Rietjens, Ivonne M. C. M.
Publicado 2016