Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice

por Berve, Kristina, West, Brian L., Martini, Rudolf, Groh, Janos
Publicado 2020

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

por Elmore, Monica R. P., Lee, Rafael J., West, Brian L., Green, Kim N.
Publicado 2015

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

por Feng, Xi, Jopson, Timothy D., Paladini, Maria Serena, Liu, Sharon, West, Brian L., Gupta, Nalin, Rosi, Susanna
Publicado 2016

Microglial depletion and activation: A [(11)C]PBR28 PET study in nonhuman primates

por Hillmer, Ansel T., Holden, Daniel, Fowles, Krista, Nabulsi, Nabeel, West, Brian L., Carson, Richard E., Cosgrove, Kelly P.
Publicado 2017

ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus

por Webb, Paul, Valentine, Cathleen, Nguyen, Phuong, Price, Richard H, Marimuthu, Adhirai, West, Brian L, Baxter, John D, Kushner, Peter J
Publicado 2003

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

por Mok, Stephen, Tsoi, Jennifer, Koya, Richard C, Hu-Lieskovan, Siwen, West, Brian L, Bollag, Gideon, Graeber, Thomas G, Ribas, Antoni
Publicado 2015

Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy

por Sluijter, Marjolein, van der Sluis, Tetje C., van der Velden, Pieter A., Versluis, Mieke, West, Brian L., van der Burg, Sjoerd H., van Hall, Thorbald
Publicado 2014

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

por Dagher, Nabil N., Najafi, Allison R., Kayala, Kara M. Neely, Elmore, Monica R. P., White, Terra E., Medeiros, Rodrigo, West, Brian L., Green, Kim N.
Publicado 2015

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

por Szalay, Gergely, Martinecz, Bernadett, Lénárt, Nikolett, Környei, Zsuzsanna, Orsolits, Barbara, Judák, Linda, Császár, Eszter, Fekete, Rebeka, West, Brian L., Katona, Gergely, Rózsa, Balázs, Dénes, Ádám
Publicado 2016

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors

por Wesolowski, Robert, Sharma, Neelesh, Reebel, Laura, Rodal, Mary Beth, Peck, Alexandra, West, Brian L., Marimuthu, Adhirai, Severson, Paul, Karlin, David A., Dowlati, Afshin, Le, Mai H., Coussens, Lisa M., Rugo, Hope S.
Publicado 2019

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

por Elmore, Monica R. P., Hohsfield, Lindsay A., Kramár, Enikö A., Soreq, Lilach, Lee, Rafael J., Pham, Stephanie T., Najafi, Allison R., Spangenberg, Elizabeth E., Wood, Marcelo A., West, Brian L., Green, Kim N.
Publicado 2018

Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments

por Allen, Barrett D., Apodaca, Lauren A., Syage, Amber R., Markarian, Mineh, Baddour, Al Anoud D., Minasyan, Harutyun, Alikhani, Leila, Lu, Celine, West, Brian L., Giedzinski, Erich, Baulch, Janet E., Acharya, Munjal M.
Publicado 2019

Mitigation of helium irradiation-induced brain injury by microglia depletion

por Allen, Barrett D., Syage, Amber R., Maroso, Mattia, Baddour, Al Anoud D., Luong, Valerie, Minasyan, Harutyun, Giedzinski, Erich, West, Brian L., Soltesz, Ivan, Limoli, Charles L., Baulch, Janet E., Acharya, Munjal M.
Publicado 2020

Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma

por Sathyasaikumar, Korrapati V., Pérez de la Cruz, Verónica, Pineda, Benjamín, Vázquez Cervantes, Gustavo Ignacio, Ramírez Ortega, Daniela, Donley, David W., Severson, Paul L., West, Brian L., Giorgini, Flaviano, Fox, Jonathan H., Schwarcz, Robert
Publicado 2022

Elimination of microglia improves cognitive function following cranial irradiation

por Acharya, Munjal M., Green, Kim N., Allen, Barrett D., Najafi, Allison R., Syage, Amber, Minasyan, Harutyun, Le, Mi T., Kawashita, Takumi, Giedzinski, Erich, Parihar, Vipan K., West, Brian L., Baulch, Janet E., Limoli, Charles L.
Publicado 2016

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms

por Fekete, Rebeka, Cserép, Csaba, Lénárt, Nikolett, Tóth, Krisztina, Orsolits, Barbara, Martinecz, Bernadett, Méhes, Előd, Szabó, Bálint, Németh, Valéria, Gönci, Balázs, Sperlágh, Beáta, Boldogkői, Zsolt, Kittel, Ágnes, Baranyi, Mária, Ferenczi, Szilamér, Kovács, Krisztina, Szalay, Gergely, Rózsa, Balázs, Webb, Connor, Kovacs, Gabor G., Hortobágyi, Tibor, West, Brian L., Környei, Zsuzsanna, Dénes, Ádám
Publicado 2018

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

por Spangenberg, Elizabeth, Severson, Paul L., Hohsfield, Lindsay A., Crapser, Joshua, Zhang, Jiazhong, Burton, Elizabeth A., Zhang, Ying, Spevak, Wayne, Lin, Jack, Phan, Nicole Y., Habets, Gaston, Rymar, Andrey, Tsang, Garson, Walters, Jason, Nespi, Marika, Singh, Parmveer, Broome, Stephanie, Ibrahim, Prabha, Zhang, Chao, Bollag, Gideon, West, Brian L., Green, Kim N.
Publicado 2019

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

por Császár, Eszter, Lénárt, Nikolett, Cserép, Csaba, Környei, Zsuzsanna, Fekete, Rebeka, Pósfai, Balázs, Balázsfi, Diána, Hangya, Balázs, Schwarcz, Anett D., Szabadits, Eszter, Szöllősi, Dávid, Szigeti, Krisztián, Máthé, Domokos, West, Brian L., Sviatkó, Katalin, Brás, Ana Rita, Mariani, Jean-Charles, Kliewer, Andrea, Lenkei, Zsolt, Hricisák, László, Benyó, Zoltán, Baranyi, Mária, Sperlágh, Beáta, Menyhárt, Ákos, Farkas, Eszter, Dénes, Ádám
Publicado 2022

Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT

por Tap, William D., Singh, Arun S., Anthony, Stephen Patrick, Sterba, Mike, Zhang, Chao, Healey, John H., Chmielowski, Bartosz, Cohn, Allen Lee, Shapiro, Geoffrey I., Keedy, Vicki L., Wainberg, Zev A., Puzanov, Igor, Cote, Gregory M., Wagner, Andrew J., Braiteh, Fadi, Sherman, Eric, Hsu, Henry H., Peterfy, Charles, Gelhorn, Heather L., Ye, Xin, Severson, Paul, West, Brian L., Lin, Paul S., Tong-Starksen, Sandra
Publicado 2022

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

por Bollag, Gideon, Hirth, Peter, Tsai, James, Zhang, Jiazhong, Ibrahim, Prabha N., Cho, Hanna, Spevak, Wayne, Zhang, Chao, Zhang, Ying, Habets, Gaston, Burton, Elizabeth A., Wong, Bernice, Tsang, Garson, West, Brian L., Powell, Ben, Shellooe, Rafe, Marimuthu, Adhirai, Nguyen, Hoa, Zhang, Kam Y. J., Artis, Dean R., Schlessinger, Joseph, Su, Fei, Higgins, Brian, Iyer, Raman, D'Andrea, Kurt, Koehler, Astrid, Stumm, Michael, Lin, Paul S., Lee, Richard J., Grippo, Joseph, Puzanov, Igor, Kim, Kevin B., Ribas, Antoni, McArthur, Grant A., Sosman, Jeffrey A., Chapman, Paul B., Flaherty, Keith T., Xu, Xiaowei, Nathanson, Katherine L., Nolop, Keith
Publicado 2010