A role for PVRL4-driven cell–cell interactions in tumorigenesis

por Pavlova, Natalya N, Pallasch, Christian, Elia, Andrew EH, Braun, Christian J, Westbrook, Thomas F, Hemann, Michael, Elledge, Stephen J
Publicado 2013

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

por Dave, Bhuvanesh, Landis, Melissa D., Dobrolecki, Lacey E., Wu, Meng-Fen, Zhang, Xiaomei, Westbrook, Thomas F., Hilsenbeck, Susan G., Liu, Dan, Lewis, Michael T., Tweardy, David J., Chang, Jenny C.
Publicado 2012

Correction: Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

por Dave, Bhuvanesh, Landis, Melissa D., Dobrolecki, Lacey E., Wu, Meng-Fen, Zhang, Xiaomei, Westbrook, Thomas F., Hilsenbeck, Susan G., Liu, Dan, Lewis, Michael T., Tweardy, David J., Chang, Jenny C.
Publicado 2012

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2

por Miao, Qi, Ku, Amy T., Nishino, Yudai, Howard, Jeffrey M., Rao, Ajay S., Shaver, Timothy M., Garcia, Gloria E., Le, Diep N., Karlin, Kristen L., Westbrook, Thomas F., Poli, Valeria, Nguyen, Hoang
Publicado 2014

Energy stress-mediated AMPK activation inhibits ferroptosis

por Lee, Hyemin, Zandkarimi, Fereshteh, Zhang, Yilei, Meena, Jitendra Kumar, Kim, Jongchan, Zhuang, Li, Tyagi, Siddhartha, Ma, Li, Westbrook, Thomas F., Steinberg, Gregory R, Nakada, Daisuke, Stockwell, Brent R., Gan, Boyi
Publicado 2020

Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6

por Arnal-Estapé, Anna, Cai, Wesley L., Albert, Alexandra E., Zhao, Minghui, Stevens, Laura E., López-Giráldez, Francesc, Patel, Kiran D., Tyagi, Siddhartha, Schmitt, Earlene M., Westbrook, Thomas F., Nguyen, Don X.
Publicado 2020

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

por Dasgupta, Subhamoy, Rajapakshe, Kimal, Zhu, Bokai, Nikolai, Bryan C., Yi, Ping, Putluri, Nagireddy, Choi, Jong Min, Jung, Sung Y., Coarfa, Cristian, Westbrook, Thomas F., Zhang, Xiang H.-F., Foulds, Charles E., Tsai, Sophia Y., Tsai, Ming-Jer, O’Malley, Bert W.
Publicado 2018

A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome

por Stylianou, Nataly, Lehman, Melanie L., Wang, Chenwei, Fard, Atefeh Taherian, Rockstroh, Anja, Fazli, Ladan, Jovanovic, Lidija, Ward, Micheal, Sadowski, Martin C., Kashyap, Abhishek S., Buttyan, Ralph, Gleave, Martin E., Westbrook, Thomas F., Williams, Elizabeth D., Gunter, Jennifer H., Nelson, Colleen C., Hollier, Brett G.
Publicado 2018

Correction: A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome

por Stylianou, Nataly, Lehman, Melanie L., Wang, Chenwei, Fard, Atefeh Taherian, Rockstroh, Anja, Fazli, Ladan, Jovanovic, Lidija, Ward, Micheal, Sadowski, Martin C., Kashyap, Abhishek S., Buttyan, Ralph, Gleave, Martin E., Westbrook, Thomas F., Williams, Elizabeth D., Gunter, Jennifer H., Nelson, Colleen C., Hollier, Brett G.
Publicado 2018

Tumor Suppressor PLK2 May Serve as a Biomarker in Triple-Negative Breast Cancer for Improved Response to PLK1 Therapeutics

por Gao, Yang, Kabotyanski, Elena B., Shepherd, Jonathan H., Villegas, Elizabeth, Acosta, Deanna, Hamor, Clark, Sun, Tingting, Montmeyor-Garcia, Celina, He, Xiaping, Dobrolecki, Lacey E., Westbrook, Thomas F., Lewis, Michael T., Hilsenbeck, Susan G., Zhang, Xiang H.-F., Perou, Charles M., Rosen, Jeffrey M.
Publicado 2021

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

por Rousseaux, Maxime WC, de Haro, Maria, Lasagna-Reeves, Cristian A, De Maio, Antonia, Park, Jeehye, Jafar-Nejad, Paymaan, Al-Ramahi, Ismael, Sharma, Ajay, See, Lauren, Lu, Nan, Vilanova-Velez, Luis, Klisch, Tiemo J, Westbrook, Thomas F, Troncoso, Juan C, Botas, Juan, Zoghbi, Huda Y
Publicado 2016

Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

por Cai, Wesley L, Chen, Jocelyn Fang-Yi, Chen, Huacui, Wingrove, Emily, Kurley, Sarah J, Chan, Lok Hei, Zhang, Meiling, Arnal-Estape, Anna, Zhao, Minghui, Balabaki, Amer, Li, Wenxue, Yu, Xufen, Krop, Ethan D, Dou, Yali, Liu, Yansheng, Jin, Jian, Westbrook, Thomas F, Nguyen, Don X, Yan, Qin
Publicado 2022

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression

por Mowery, Cody T., Reyes, Jaime M., Cabal-Hierro, Lucia, Higby, Kelly J., Karlin, Kristen L., Wang, Jarey H., Kimmerling, Robert J., Cejas, Paloma, Lim, Klothilda, Li, Hubo, Furusawa, Takashi, Long, Henry W., Pellman, David, Chapuy, Bjoern, Bustin, Michael, Manalis, Scott R., Westbrook, Thomas F., Lin, Charles Y., Lane, Andrew A.
Publicado 2018

Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation

por Welte, Thomas, Kim, Ik Sun, Tian, Lin, Gao, Xia, Wang, Hai, Li, June, Holdman, Xue B., Herschkowitz, Jason I., Pond, Adam, Xie, Guorui, Kurley, Sarah, Nguyen, Tuan, Liao, Lan, Dobrolecki, Lacey E., Mo, Qianxing, Edwards, Dean P., Huang, Shixia, Xin, Li, Xu, Jianming, Li, Yi, Lewis, Michael T., Wang, Tian, Westbrook, Thomas F., Rosen, Jeffrey M., Zhang, Xiang H.-F.
Publicado 2016

iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells

por Bouguenina, Habib, Nicolaou, Stephanos, Le Bihan, Yann-Vaï, Bowling, Elizabeth A., Calderon, Cheyenne, Caldwell, John J., Harrington, Brinley, Hayes, Angela, McAndrew, P. Craig, Mitsopoulos, Costas, Sialana, Fernando Jr., Scarpino, Andrea, Stubbs, Mark, Thapaliya, Arjun, Tyagi, Siddhartha, Wang, Hannah Z., Wood, Francesca, Burke, Rosemary, Raynaud, Florence, Choudhary, Jyoti, van Montfort, Rob L.M., Sadok, Amine, Westbrook, Thomas F., Collins, Ian, Chopra, Rajesh
Publicado 2023

Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms

por Kim, Ik Sun, Gao, Yang, Welte, Thomas, Wang, Hai, Liu, Jun, Janghorban, Mahnaz, Sheng, Kuanwei, Niu, Yichi, Goldstein, Amit, Zhao, Na, Bado, Igor, Lo, Hin-Ching, Toneff, Michael J., Nguyen, Tuan, Bu, Wen, Jiang, Weiyu, Arnold, James, Gu, Franklin, He, Jian, Jebakumar, Deborah, Walker, Kimberly, Li, Yi, Mo, Qianxing, Westbrook, Thomas F., Zong, Chenghang, Rao, Arundhati, Sreekumar, Arun, Rosen, Jeffrey M., Zhang, Xiang H.-F.
Publicado 2019

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-a...

por Fu, Xiaoyong, Creighton, Chad J, Biswal, Nrusingh C, Kumar, Vijetha, Shea, Martin, Herrera, Sabrina, Contreras, Alejandro, Gutierrez, Carolina, Wang, Tao, Nanda, Sarmistha, Giuliano, Mario, Morrison, Gladys, Nardone, Agostina, Karlin, Kristen L, Westbrook, Thomas F, Heiser, Laura M, Anur, Pavana, Spellman, Paul, Guichard, Sylvie M, Smith, Paul D, Davies, Barry R, Klinowska, Teresa, Lee, Adrian V, Mills, Gordon B, Rimawi, Mothaffar F, Hilsenbeck, Susan G, Gray, Joe W, Joshi, Amit, Osborne, C Kent, Schiff, Rachel
Publicado 2014

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

por Hsu, Tiffany Y-T., Simon, Lukas M., Neill, Nicholas, Marcotte, Richard, Sayad, Azin, Bland, Christopher S., Echeverria, Gloria V., Sun, Tingting, Kurley, Sarah J., Tyagi, Siddhartha, Karlin, Kristen L., Dominguez-Vidaña, Rocio, Hartman, Jessica D., Renwick, Alexander, Scorsone, Kathleen, Bernardi, Ronald J., Skinner, Samuel O., Jain, Antrix, Orellana, Mayra, Lagisetti, Chandraiah, Golding, Ido, Jung, Sung Y., Neilson, Joel R., Zhang, Xiang H.-F., Cooper, Thomas A., Webb, Thomas R., Neel, Benjamin G., Shaw, Chad A., Westbrook, Thomas F.
Publicado 2015

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy

por Krug, Karsten, Jaehnig, Eric J., Satpathy, Shankha, Blumenberg, Lili, Karpova, Alla, Anurag, Meenakshi, Miles, George, Mertins, Philipp, Geffen, Yifat, Tang, Lauren C., Heiman, David I., Cao, Song, Maruvka, Yosef E., Lei, Jonathan T., Huang, Chen, Kothadia, Ramani B., Colaprico, Antonio, Birger, Chet, Wang, Jarey, Dou, Yongchao, Wen, Bo, Shi, Zhiao, Liao, Yuxing, Wiznerowicz, Maciej, Wyczalkowski, Matthew A., Chen, Xi Steven, Kennedy, Jacob J., Paulovich, Amanda G., Thiagarajan, Mathangi, Kinsinger, Christopher R., Hiltke, Tara, Boja, Emily S., Mesri, Mehdi, Robles, Ana I., Rodriguez, Henry, Westbrook, Thomas F., Ding, Li, Getz, Gad, Clauser, Karl R., Fenyö, David, Ruggles, Kelly V., Zhang, Bing, Mani, D.R., Carr, Steven A., Ellis, Matthew J., Gillette, Michael A.
Publicado 2020