Synthesis and Biological Evaluation of Bicalutamide Analogues for the Potential Treatment of Prostate Cancer

por Kandil, Sahar B., McGuigan, Christopher, Westwell, Andrew D.
Publicado 2020

New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2

por Hamdy, Rania, Elseginy, Samia A., Ziedan, Noha I., Jones, Arwyn T., Westwell, Andrew D.
Publicado 2019

ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites

por Kandil, Sahar, Balzarini, Jan, Rat, Stephanie, Brancale, Andrea, Westwell, Andrew D., McGuigan, Christopher
Publicado 2016

Structure-Based Virtual Screening, Synthesis and Biological Evaluation of Potential FAK-FAT Domain Inhibitors for Treatment of Metastatic Cancer

por Kandil, Sahar B., Jones, Samuel R., Smith, Sonia, Hiscox, Stephen E., Westwell, Andrew D.
Publicado 2020

The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer

por Wymant, Jennifer M., Hiscox, Stephen, Westwell, Andrew D., Urbé, Sylvie, Clague, Michael J., Jones, Arwyn T.
Publicado 2016

Design, Synthesis, and Potent Anticancer Activity of Novel Indole-Based Bcl-2 Inhibitors

por Almehdi, Ahmed M., Soliman, Sameh S. M., El-Shorbagi, Abdel-Nasser A., Westwell, Andrew D., Hamdy, Rania
Publicado 2023

Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells

por Kandil, Sahar, Wymant, Jennifer M., Kariuki, Benson M., Jones, Arwyn T., McGuigan, Christopher, Westwell, Andrew D.
Publicado 2016

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative

por Hendriks, Hans R, Govaerts, Anne-Sophie, Fichtner, Iduna, Burtles, Sally, Westwell, Andrew D, Peters, Godefridus J
Publicado 2017

Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents

por Bassetto, Marcella, Ferla, Salvatore, Giancotti, Gilda, Pertusati, Fabrizio, Westwell, Andrew D., Brancale, Andrea, McGuigan, Christopher
Publicado 2017

The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation

por Crusco, Alessandra, Baptista, Rafael, Bhowmick, Sumana, Beckmann, Manfred, Mur, Luis A. J., Westwell, Andrew D., Hoffmann, Karl F.
Publicado 2019

Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2

por Hamdy, Rania, Elseginy, Samia A., Ziedan, Noha I., El-Sadek, Mohamed, Lashin, Elsaid, Jones, Arwyn T., Westwell, Andrew D.
Publicado 2020

Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells

por Wiggins, Helen L., Wymant, Jennifer M., Solfa, Francesca, Hiscox, Stephen E., Taylor, Kathryn M., Westwell, Andrew D., Jones, Arwyn T.
Publicado 2015

Radiosynthesis of [(18)F]-Labelled Pro-Nucleotides (ProTides)

por Cavaliere, Alessandra, Probst, Katrin C., Paisey, Stephen J., Marshall, Christopher, Dheere, Abdul K. H., Aigbirhio, Franklin, McGuigan, Christopher, Westwell, Andrew D.
Publicado 2020

New Bioactive Fused Triazolothiadiazoles as Bcl-2-Targeted Anticancer Agents

por Hamdy, Rania, Jones, Arwyn T., El-Sadek, Mohamed, Hamoda, Alshaimaa M., Shakartalla, Sarra B., AL Shareef, Zainab M., Soliman, Sameh S. M., Westwell, Andrew D.
Publicado 2021

RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance

por Somasagara, Ranganatha R., Spencer, Sebastian M., Tripathi, Kaushlendra, Clark, David W., Mani, Chinnadurai, da Silva, Luciana Madeira, Scalici, Jennifer, Kothayer, Hend, Westwell, Andrew D., Rocconi, Rodney P., Palle, Komaraiah
Publicado 2017

A framework for the development of effective anti-metastatic agents

por Anderson, Robin L., Balasas, Theo, Callaghan, Juliana, Coombes, R. Charles, Evans, Jeff, Hall, Jacqueline A., Kinrade, Sally, Jones, David, Jones, Paul S., Jones, Rob, Marshall, John F., Panico, Maria Beatrice, Shaw, Jacqui A., Steeg, Patricia S., Sullivan, Mark, Tong, Warwick, Westwell, Andrew D., Ritchie, James W. A.
Publicado 2018

Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid‐organ cancers...

por Scurr, Martin J., Zelek, Wioleta M., Lippiatt, George, Somerville, Michelle, Burnell, Stephanie E. A., Capitani, Lorenzo, Davies, Kate, Lawton, Helen, Tozer, Thomas, Rees, Tara, Roberts, Kerry, Evans, Mererid, Jackson, Amanda, Young, Charlotte, Fairclough, Lucy, Tighe, Paddy, Wills, Mark, Westwell, Andrew D., Morgan, B. Paul, Gallimore, Awen, Godkin, Andrew
Publicado 2021