Modifiers of CAG/CTG Repeat Instability: Insights from Mammalian Models

por Wheeler, Vanessa C., Dion, Vincent
Publicado 2021

Special Issue: DNA Repair and Somatic Repeat Expansion in Huntington’s Disease

por Jones, Lesley, Wheeler, Vanessa C., Pearson, Christopher E.
Publicado 2021

Quantification of Age-Dependent Somatic CAG Repeat Instability in Hdh CAG Knock-In Mice Reveals Different Expansion Dynamics in Striatum and Liver

por Lee, Jong-Min, Pinto, Ricardo Mouro, Gillis, Tammy, St. Claire, Jason C., Wheeler, Vanessa C.
Publicado 2011

Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice

por Goula, Agathi-Vassiliki, Berquist, Brian R., Wilson, David M., Wheeler, Vanessa C., Trottier, Yvon, Merienne, Karine
Publicado 2009

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice

por Neto, João Luís, Lee, Jong-Min, Afridi, Ali, Gillis, Tammy, Guide, Jolene R., Dempsey, Stephani, Lager, Brenda, Alonso, Isabel, Wheeler, Vanessa C., Pinto, Ricardo Mouro
Publicado 2017

Chromosome substitution strain assessment of a Huntington’s disease modifier locus

por Ramos, Eliana Marisa, Kovalenko, Marina, Guide, Jolene R., St. Claire, Jason, Gillis, Tammy, Mysore, Jayalakshmi S., Sequeiros, Jorge, Wheeler, Vanessa C., Alonso, Isabel, MacDonald, Marcy E.
Publicado 2015

Assessing average somatic CAG repeat instability at the protein level

por Aviolat, Hubert, Pinto, Ricardo Mouro, Godschall, Elizabeth, Murtha, Ryan, Richey, Hannah E., Sapp, Ellen, Vodicka, Petr, Wheeler, Vanessa C., Kegel-Gleason, Kimberly B., DiFiglia, Marian
Publicado 2019

HD CAGnome: A Search Tool for Huntingtin CAG Repeat Length-Correlated Genes

por Galkina, Ekaterina I., Shin, Aram, Coser, Kathryn R., Shioda, Toshi, Kohane, Isaac S., Seong, Ihn Sik, Wheeler, Vanessa C., Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min
Publicado 2014

Approaches to Sequence the HTT CAG Repeat Expansion and Quantify Repeat Length Variation

por Ciosi, Marc, Cumming, Sarah A., Chatzi, Afroditi, Larson, Eloise, Tottey, William, Lomeikaite, Vilija, Hamilton, Graham, Wheeler, Vanessa C., Pinto, Ricardo Mouro, Kwak, Seung, Morton, A. Jennifer, Monckton, Darren G.
Publicado 2021

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice

por Kovalenko, Marina, Dragileva, Ella, St. Claire, Jason, Gillis, Tammy, Guide, Jolene R., New, Jaclyn, Dong, Hualing, Kucherlapati, Raju, Kucherlapati, Melanie H., Ehrlich, Michelle E., Lee, Jong-Min, Wheeler, Vanessa C.
Publicado 2012

Huntington’s Disease Pathogenesis: Two Sequential Components

por Hong, Eun Pyo, MacDonald, Marcy E., Wheeler, Vanessa C., Jones, Lesley, Holmans, Peter, Orth, Michael, Monckton, Darren G., Long, Jeffrey D., Kwak, Seung, Gusella, James F., Lee, Jong-Min
Publicado 2021

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection

por Roy, Jennie C L, Vitalo, Antonia, Andrew, Marissa A, Mota-Silva, Eduarda, Kovalenko, Marina, Burch, Zoe, Nhu, Anh M, Cohen, Paula E, Grabczyk, Ed, Wheeler, Vanessa C, Mouro Pinto, Ricardo
Publicado 2021

CAG repeat expansion in the Huntington’s disease gene shapes linear and circular RNAs biogenesis

por Ayyildiz, Dilara, Bergonzoni, Guendalina, Monziani, Alan, Tripathi, Takshashila, Döring, Jessica, Kerschbamer, Emanuela, Di Leva, Francesca, Pennati, Elia, Donini, Luisa, Kovalenko, Marina, Zasso, Jacopo, Conti, Luciano, Wheeler, Vanessa C., Dieterich, Christoph, Piazza, Silvano, Dassi, Erik, Biagioli, Marta
Publicado 2023

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

por Kovalenko, Marina, Erdin, Serkan, Andrew, Marissa A, St Claire, Jason, Shaughnessey, Melissa, Hubert, Leroy, Neto, João Luís, Stortchevoi, Alexei, Fass, Daniel M, Mouro Pinto, Ricardo, Haggarty, Stephen J, Wilson, John H, Talkowski, Michael E, Wheeler, Vanessa C
Publicado 2020

A novel approach to investigate tissue-specific trinucleotide repeat instability

por Lee, Jong-Min, Zhang, Jie, Su, Andrew I, Walker, John R, Wiltshire, Tim, Kang, Kihwa, Dragileva, Ella, Gillis, Tammy, Lopez, Edith T, Boily, Marie-Josee, Cyr, Michel, Kohane, Isaac, Gusella, James F, MacDonald, Marcy E, Wheeler, Vanessa C
Publicado 2010

Htt(Q111/+) Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction

por Kovalenko, Marina, Milnerwood, Austen, Giordano, James, St. Claire, Jason, Guide, Jolene R., Stromberg, Mary, Gillis, Tammy, Sapp, Ellen, DiFiglia, Marian, MacDonald, Marcy E., Carroll, Jeffrey B., Lee, Jong-Min, Tappan, Susan, Raymond, Lynn, Wheeler, Vanessa C.
Publicado 2018

Huntingtin facilitates polycomb repressive complex 2

por Seong, Ihn Sik, Woda, Juliana M., Song, Ji-Joon, Lloret, Alejandro, Abeyrathne, Priyanka D., Woo, Caroline J., Gregory, Gillian, Lee, Jong-Min, Wheeler, Vanessa C., Walz, Thomas, Kingston, Robert E., Gusella, James F., Conlon, Ronald A., MacDonald, Marcy E.
Publicado 2010

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

por Pinto, Ricardo Mouro, Dragileva, Ella, Kirby, Andrew, Lloret, Alejandro, Lopez, Edith, St. Claire, Jason, Panigrahi, Gagan B., Hou, Caixia, Holloway, Kim, Gillis, Tammy, Guide, Jolene R., Cohen, Paula E., Li, Guo-Min, Pearson, Christopher E., Daly, Mark J., Wheeler, Vanessa C.
Publicado 2013

Transcriptional regulatory networks underlying gene expression changes in Huntington's disease

por Ament, Seth A, Pearl, Jocelynn R, Cantle, Jeffrey P, Bragg, Robert M, Skene, Peter J, Coffey, Sydney R, Bergey, Dani E, Wheeler, Vanessa C, MacDonald, Marcy E, Baliga, Nitin S, Rosinski, Jim, Hood, Leroy E, Carroll, Jeffrey B, Price, Nathan D
Publicado 2018

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out

por Loupe, Jacob M, Pinto, Ricardo Mouro, Kim, Kyung-Hee, Gillis, Tammy, Mysore, Jayalakshmi S, Andrew, Marissa A, Kovalenko, Marina, Murtha, Ryan, Seong, IhnSik, Gusella, James F, Kwak, Seung, Howland, David, Lee, Ramee, Lee, Jong-Min, Wheeler, Vanessa C, MacDonald, Marcy E
Publicado 2020