Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy

por Martin, Nikolas T., Crupi, Mathieu J. F., Taha, Zaid, Poutou, Joanna, Whelan, Jack T., Vallati, Sydney, Petryk, Julia, Marius, Ricardo, Austin, Bradley, Azad, Taha, Boulanger, Mason, Burgess, Tamara, Sanders, Ilson, Victoor, Camille, Dickinson, Bryan C., Diallo, Jean-Simon, Ilkow, Carolina S., Bell, John C.
Publicado 2023

Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization

por Azad, Taha, Singaravelu, Ragunath, Crupi, Mathieu J.F., Jamieson, Taylor, Dave, Jaahnavi, Brown, Emily E.F., Rezaei, Reza, Taha, Zaid, Boulton, Stephen, Martin, Nikolas T., Surendran, Abera, Poutou, Joanna, Ghahremani, Mina, Nouri, Kazem, Whelan, Jack T., Duong, Jessie, Tucker, Sarah, Diallo, Jean-Simon, Bell, John C., Ilkow, Carolina S.
Publicado 2020

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

por Whelan, Jack T., Singaravelu, Ragunath, Wang, Fuan, Pelin, Adrian, Tamming, Levi A., Pugliese, Giuseppe, Martin, Nikolas T., Crupi, Mathieu J. F., Petryk, Julia, Austin, Bradley, He, Xiaohong, Marius, Ricardo, Duong, Jessie, Jones, Carter, Fekete, Emily E. F., Alluqmani, Nouf, Chen, Andrew, Boulton, Stephen, Huh, Michael S., Tang, Matt Y., Taha, Zaid, Scut, Elena, Diallo, Jean-Simon, Azad, Taha, Lichty, Brian D., Ilkow, Carolina S., Bell, John C.
Publicado 2023

Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection

por Boulton, Stephen, Poutou, Joanna, Martin, Nikolas T., Azad, Taha, Singaravelu, Ragunath, Crupi, Mathieu J.F., Jamieson, Taylor, He, Xiaohong, Marius, Ricardo, Petryk, Julia, Tanese de Souza, Christiano, Austin, Bradley, Taha, Zaid, Whelan, Jack, Khan, Sarwat T., Pelin, Adrian, Rezaei, Reza, Surendran, Abera, Tucker, Sarah, Brown, Emily E.F., Dave, Jaahnavi, Diallo, Jean-Simon, Auer, Rebecca, Angel, Jonathan B., Cameron, D. William, Cailhier, Jean-Francois, Lapointe, Réjean, Potts, Kyle, Mahoney, Douglas J., Bell, John C., Ilkow, Carolina S.
Publicado 2022