Phenotypic lentivirus screens to identify functional single domain antibodies

por Schmidt, Florian I., Hanke, Leo, Morin, Benjamin, Brewer, Rebeccah, Brusic, Vesna, Whelan, Sean P.J., Ploegh, Hidde L.
Publicado 2016

Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor

por Jenni, Simon, Bloyet, Louis-Marie, Diaz-Avalos, Ruben, Liang, Bo, Whelan, Sean P.J., Grigorieff, Nikolaus, Harrison, Stephen C.
Publicado 2020

FXa cleaves the SARS-CoV-2 spike protein and blocks cell entry to protect against infection with inferior effects in B.1.1.7 variant

por Dong, Wenjuan, Wang, Jing, Tian, Lei, Zhang, Jianying, Mead, Heather, Jaramillo, Sierra A., Li, Aimin, Zumwalt, Ross E., Whelan, Sean P.J., Settles, Erik W., Keim, Paul S., Barker, Bridget Marie, Caligiuri, Michael A., Yu, Jianhua
Publicado 2021

Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD

por Errico, John M., Zhao, Haiyan, Chen, Rita E., Liu, Zhuoming, Case, James Brett, Ma, Meisheng, Schmitz, Aaron J., Rau, Michael J., Fitzpatrick, James A.J., Shi, Pei-Yong, Diamond, Michael S., Whelan, Sean P.J., Ellebedy, Ali H., Fremont, Daved H.
Publicado 2021

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis

por Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Kafai, Natasha M., Fox, Julie M., Shrihari, Swathi, McCune, Broc T., Harvey, Ian B., Smith, Brittany, Keeler, Shamus P., Bloyet, Louis-Marie, Winkler, Emma S., Holtzman, Michael J., Fremont, Daved H., Whelan, Sean P.J., Diamond, Michael S.
Publicado 2020

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

por Liu, Zhuoming, VanBlargan, Laura A., Bloyet, Louis-Marie, Rothlauf, Paul W., Chen, Rita E., Stumpf, Spencer, Zhao, Haiyan, Errico, John M., Theel, Elitza S., Liebeskind, Mariel J., Alford, Brynn, Buchser, William J., Ellebedy, Ali H., Fremont, Daved H., Diamond, Michael S., Whelan, Sean P.J.
Publicado 2021

A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination

por Greene, Sarah E., Huang, Yuefang, Kim, Wooseob, Liebeskind, Mariel J., Chandrasekaran, Vinay, Liu, Zhuoming, Deepak, Parakkal, Paley, Michael A., Lew, Daphne, Yang, Monica, Matloubian, Mehrdad, Gensler, Lianne S., Nakamura, Mary C., O'Hallaran, Jane A., Presti, Rachel M., Whelan, Sean P.J., Buchser, William J., Kim, Alfred H.J., Weil, Gary J.
Publicado 2023

Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice

por Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Kafai, Natasha M., Fox, Julie M., Smith, Brittany K., Shrihari, Swathi, McCune, Broc T., Harvey, Ian B., Keeler, Shamus P., Bloyet, Louis-Marie, Zhao, Haiyan, Ma, Meisheng, Adams, Lucas J., Winkler, Emma S., Holtzman, Michael J., Fremont, Daved H., Whelan, Sean P.J., Diamond, Michael S.
Publicado 2020

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

por Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.
Publicado 2020

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

por Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.
Publicado 2021

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

por Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Liu, Zhuoming, Zhao, Haiyan, Kim, Arthur S., Bloyet, Louis-Marie, Zeng, Qiru, Tahan, Stephen, Droit, Lindsay, Ilagan, Ma. Xenia G., Tartell, Michael A., Amarasinghe, Gaya, Henderson, Jeffrey P., Miersch, Shane, Ustav, Mart, Sidhu, Sachdev, Virgin, Herbert W., Wang, David, Ding, Siyuan, Corti, Davide, Theel, Elitza S., Fremont, Daved H., Diamond, Michael S., Whelan, Sean P.J.
Publicado 2020

A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants

por Schmitz, Aaron J., Turner, Jackson S., Liu, Zhuoming, Aziati, Ishmael D., Chen, Rita E., Joshi, Astha, Bricker, Traci L., Darling, Tamarand L., Adelsberg, Daniel C., Alsoussi, Wafaa B., Case, James Brett, Lei, Tingting, Thapa, Mahima, Amanat, Fatima, O’Halloran, Jane A., Shi, Pei-Yong, Presti, Rachel M., Krammer, Florian, Bajic, Goran, Whelan, Sean P.J., Diamond, Michael S., Boon, Adrianus C. M., Ellebedy, Ali H.
Publicado 2021

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

por Puray-Chavez, Maritza, LaPak, Kyle M., Schrank, Travis P., Elliott, Jennifer L., Bhatt, Dhaval P., Agajanian, Megan J., Jasuja, Ria, Lawson, Dana Q., Davis, Keanu, Rothlauf, Paul W., Jo, Heejoon, Lee, Nakyung, Tenneti, Kasyap, Eschbach, Jenna E., Mugisha, Christian Shema, Vuong, Hung R., Bailey, Adam L., Hayes, D. Neil, Whelan, Sean P.J., Horani, Amjad, Brody, Steven L., Goldfarb, Dennis, Major, M. Ben, Kutluay, Sebla B.
Publicado 2021

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

por VanBlargan, Laura A., Adams, Lucas J., Liu, Zhuoming, Chen, Rita E., Gilchuk, Pavlo, Raju, Saravanan, Smith, Brittany K., Zhao, Haiyan, Case, James Brett, Winkler, Emma S., Whitener, Bradley M., Droit, Lindsay, Aziati, Ishmael D., Bricker, Traci L., Joshi, Astha, Shi, Pei-Yong, Creanga, Adrian, Pegu, Amarendra, Handley, Scott A., Wang, David, Boon, Adrianus C.M., Crowe, James E., Whelan, Sean P.J., Fremont, Daved H., Diamond, Michael S.
Publicado 2021

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

por Park, Young-Jun, De Marco, Anna, Starr, Tyler N, Liu, Zhuoming, Pinto, Dora, Walls, Alexandra C., Zatta, Fabrizia, Zepeda, Samantha K., Bowen, John, Sprouse, Kaitlin S, Joshi, Anshu, Giurdanella, Martina, Guarino, Barbara, Noack, Julia, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Lempp, Florian A., Benigni, Fabio, Snell, Gyorgy, Neyts, Johan, Whelan, Sean PJ, Virgin, Herbert W., Bloom, Jesse D, Corti, Davide, Pizzuto, Matteo Samuele, Veesler, David
Publicado 2021

JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis

por Son, Juhee, Huang, Shimeng, Zeng, Qiru, Bricker, Traci L., Case, James Brett, Zhou, Jinzhu, Zang, Ruochen, Liu, Zhuoming, Chang, Xinjian, Harastani, Houda H., Chen, Lu, Castro, Maria Florencia Gomez, Zhao, Yongxiang, Kohio, Hinissan P., Hou, Gaopeng, Fan, Baochao, Niu, Beibei, Guo, Rongli, Rothlauf, Paul W., Bailey, Adam L., Wang, Xin, Shi, Pei-Yong, Martinez, Elisabeth D., Whelan, Sean P.J., Diamond, Michael S., Boon, Adrianus C.M., Li, Bin, Ding, Siyuan
Publicado 2021

A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants

por Schmitz, Aaron J., Turner, Jackson S., Liu, Zhuoming, Zhou, Julian Q., Aziati, Ishmael D., Chen, Rita E., Joshi, Astha, Bricker, Traci L., Darling, Tamarand L., Adelsberg, Daniel C., Altomare, Clara G., Alsoussi, Wafaa B., Case, James Brett, VanBlargan, Laura A., Lei, Tingting, Thapa, Mahima, Amanat, Fatima, Jeevan, Trushar, Fabrizio, Thomas, O’Halloran, Jane A., Shi, Pei-Yong, Presti, Rachel M., Webby, Richard J., Krammer, Florian, Whelan, Sean P.J., Bajic, Goran, Diamond, Michael S., Boon, Adrianus C.M., Ellebedy, Ali H.
Publicado 2021

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

por McCallum, Matthew, De Marco, Anna, Lempp, Florian A., Tortorici, M. Alejandra, Pinto, Dora, Walls, Alexandra C., Beltramello, Martina, Chen, Alex, Liu, Zhuoming, Zatta, Fabrizia, Zepeda, Samantha, di Iulio, Julia, Bowen, John E., Montiel-Ruiz, Martin, Zhou, Jiayi, Rosen, Laura E., Bianchi, Siro, Guarino, Barbara, Fregni, Chiara Silacci, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Rothlauf, Paul W., Bloyet, Louis-Marie, Benigni, Fabio, Cameroni, Elisabetta, Neyts, Johan, Riva, Agostino, Snell, Gyorgy, Telenti, Amalio, Whelan, Sean P.J., Virgin, Herbert W., Corti, Davide, Pizzuto, Matteo Samuele, Veesler, David
Publicado 2021

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

por Puray-Chavez, Maritza, LaPak, Kyle M., Schrank, Travis P., Elliott, Jennifer L., Bhatt, Dhaval P., Agajanian, Megan J., Jasuja, Ria, Lawson, Dana Q., Davis, Keanu, Rothlauf, Paul W., Liu, Zhuoming, Jo, Heejoon, Lee, Nakyung, Tenneti, Kasyap, Eschbach, Jenna E., Shema Mugisha, Christian, Cousins, Emily M., Cloer, Erica W., Vuong, Hung R., VanBlargan, Laura A., Bailey, Adam L., Gilchuk, Pavlo, Crowe, James E., Diamond, Michael S., Hayes, D. Neil, Whelan, Sean P.J., Horani, Amjad, Brody, Steven L., Goldfarb, Dennis, Major, M. Ben, Kutluay, Sebla B.
Publicado 2021

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

por Alsoussi, Wafaa B., Malladi, Sameer K., Zhou, Julian Q., Liu, Zhuoming, Ying, Baoling, Kim, Wooseob, Schmitz, Aaron J., Lei, Tingting, Horvath, Stephen C., Sturtz, Alexandria J., McIntire, Katherine M., Evavold, Birk, Han, Fangjie, Scheaffer, Suzanne M., Fox, Isabella F., Parra-Rodriguez, Luis, Nachbagauer, Raffael, Nestorova, Biliana, Chalkias, Spyros, Farnsworth, Christopher W., Klebert, Michael K., Pusic, Iskra, Strnad, Benjamin S., Middleton, William D., Teefey, Sharlene A., Whelan, Sean P.J., Diamond, Michael S., Paris, Robert, O’Halloran, Jane A., Presti, Rachel M., Turner, Jackson S., Ellebedy, Ali H.
Publicado 2022