ABCB1 Overexpression Is a Key Initiator of Resistance to Tyrosine Kinase Inhibitors in CML Cell Lines

por Eadie, Laura N., Hughes, Timothy P., White, Deborah L.
Publicado 2016

DUX Hunting—Clinical Features and Diagnostic Challenges Associated with DUX4-Rearranged Leukaemia

por Rehn, Jacqueline A., O’Connor, Matthew J., White, Deborah L., Yeung, David T.
Publicado 2020

Multi-Cohort Transcriptomic Subtyping of B-Cell Acute Lymphoblastic Leukemia

por Mäkinen, Ville-Petteri, Rehn, Jacqueline, Breen, James, Yeung, David, White, Deborah L.
Publicado 2022

ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells

por Eadie, Laura N., Dang, Phuong, Goyne, Jarrad M., Hughes, Timothy P., White, Deborah L.
Publicado 2018

The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro

por Eadie, Laura N., Saunders, Verity A., Branford, Susan, White, Deborah L., Hughes, Timothy P.
Publicado 2018

Gain of chromosome 21 increases the propensity for P2RY8: :CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression

por Page, Elyse C., Heatley, Susan L., Rehn, Jacqueline, Thomas, Paul Q., Yeung, David T., White, Deborah L.
Publicado 2023

The acquisition order of leukemic drug resistance mutations is directed by the selective fitness associated with each resistance mechanism

por Leow, Benjamin C. S., Kok, Chung H., Yeung, David T., Hughes, Timothy P., White, Deborah L., Eadie, Laura N.
Publicado 2023

The effect of co-occurring lesions on leukaemogenesis and drug response in T-ALL and ETP-ALL

por Tavakoli Shirazi, Paniz, Eadie, Laura N., Heatley, Susan L., Hughes, Timothy P., Yeung, David T., White, Deborah L.
Publicado 2019

Solute Carrier Family 29A1 Mediates In Vitro Resistance to Azacitidine in Acute Myeloid Leukemia Cell Lines

por Kutyna, Monika M., Loone, Sophie, Saunders, Verity A., White, Deborah L., Kok, Chung H., Hiwase, Devendra K.
Publicado 2023

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia

por Downes, Charlotte E. J., McClure, Barbara J., Bruning, John B., Page, Elyse, Breen, James, Rehn, Jacqueline, Yeung, David T., White, Deborah L.
Publicado 2021

Increased peroxisome proliferator-activated receptor γ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells

por Wang, Jueqiong, Lu, Liu, Kok, Chung H., Saunders, Verity A., Goyne, Jarrad M., Dang, Phuong, Leclercq, Tamara M., Hughes, Timothy P., White, Deborah L.
Publicado 2017

JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies

por Downes, Charlotte EJ., McClure, Barbara J., McDougal, Daniel P., Heatley, Susan L., Bruning, John B., Thomas, Daniel, Yeung, David T., White, Deborah L.
Publicado 2022

Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression

por McClure, Barbara J., Heatley, Susan L., Kok, Chung H, Sadras, Teresa, An, Jiyuan, Hughes, Timothy P., Lock, Richard B., Yeung, David, Sutton, Rosemary, White, Deborah L
Publicado 2018

Case Report: Precision Medicine Target Revealed by In Vitro Modeling of Relapsed, Refractory Acute Lymphoblastic Leukemia From a Child With Neurofibromatosis

por Heatley, Susan L., Page, Elyse C., Eadie, Laura N., McClure, Barbara J., Rehn, Jacqueline, Yeung, David T., Osborn, Michael, Revesz, Tamas, Kirby, Maria, White, Deborah L.
Publicado 2022

RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL)

por Rehn, Jacqueline, Mayoh, Chelsea, Heatley, Susan L, McClure, Barbara J, Eadie, Laura N, Schutz, Caitlin, Yeung, David T, Cowley, Mark J, Breen, James, White, Deborah L
Publicado 2022

BCR-ABL1 genomic DNA PCR response kinetics during first-line imatinib treatment of chronic myeloid leukemia

por Pagani, Ilaria S., Dang, Phuong, Kommers, Ivar O., Goyne, Jarrad M., Nicola, Mario, Saunders, Verity A., Braley, Jodi, White, Deborah L., Yeung, David T., Branford, Susan, Hughes, Timothy P., Ross, David M.
Publicado 2018

COBL is a novel hotspot for IKZF1 deletions in childhood acute lymphoblastic leukemia

por Lopes, Bruno Almeida, Meyer, Claus, Barbosa, Thayana Conceição, zur Stadt, Udo, Horstmann, Martin, Venn, Nicola C., Heatley, Susan, White, Deborah L., Sutton, Rosemary, Pombo-de-Oliveira, Maria S., Marschalek, Rolf, Emerenciano, Mariana
Publicado 2016

Case Report: Rare IKZF1 Gene Fusions Identified in Neonate with Congenital KMT2A-Rearranged Acute Lymphoblastic Leukemia

por Eadie, Laura N., Rehn, Jacqueline A., Breen, James, Osborn, Michael P., Jessop, Sophie, Downes, Charlotte E. J., Heatley, Susan L., McClure, Barbara J., Yeung, David T., Revesz, Tamas, Saxon, Benjamin, White, Deborah L.
Publicado 2023

Reproducible Bioinformatics Analysis Workflows for Detecting IGH Gene Fusions in B-Cell Acute Lymphoblastic Leukaemia Patients

por Thomson, Ashlee J., Rehn, Jacqueline A., Heatley, Susan L., Eadie, Laura N., Page, Elyse C., Schutz, Caitlin, McClure, Barbara J., Sutton, Rosemary, Dalla-Pozza, Luciano, Moore, Andrew S., Greenwood, Matthew, Kotecha, Rishi S., Fong, Chun Y., Yong, Agnes S. M., Yeung, David T., Breen, James, White, Deborah L.
Publicado 2023

Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten

por Nair, Shalima S., Luu, Phuc-Loi, Qu, Wenjia, Maddugoda, Madhavi, Huschtscha, Lily, Reddel, Roger, Chenevix-Trench, Georgia, Toso, Martina, Kench, James G., Horvath, Lisa G., Hayes, Vanessa M., Stricker, Phillip D., Hughes, Timothy P., White, Deborah L., Rasko, John E. J., Wong, Justin J.-L., Clark, Susan J.
Publicado 2018