Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism

por Kumar, Gyanendra, Cuypers, Maxime, Webby, Richard R, Webb, Thomas R, White, Stephen W
Publicado 2021

A statistical framework to evaluate virtual screening

por Zhao, Wei, Hevener, Kirk E, White, Stephen W, Lee, Richard E, Boyett, James M
Publicado 2009

Structural Basis for the Transcriptional Regulation of Membrane Lipid Homeostasis

por Miller, Darcie J., Zhang, Yong-Mei, Subramanian, Chitra, Rock, Charles O., White, Stephen W.
Publicado 2010

Domain architecture and catalysis of the Staphylococcus aureus fatty acid kinase

por Subramanian, Chitra, Cuypers, Maxime G., Radka, Christopher D., White, Stephen W., Rock, Charles O.
Publicado 2022

A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay

por Wu, Qiong, Lin, Wenwei, Li, Zhen-Mei, Rankovic, Zoran, White, Stephen W., Chen, Taosheng, Yang, Jun
Publicado 2021

Acid Stability of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity

por DuBois, Rebecca M., Zaraket, Hassan, Reddivari, Muralidhar, Heath, Richard J., White, Stephen W., Russell, Charles J.
Publicado 2011

Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis

por Pemble, Charles W., Mehta, Perdeep K., Mehra, Smriti, Li, Zhenmei, Nourse, Amanda, Lee, Richard E., White, Stephen W.
Publicado 2010

Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties

por Xiao, Min, Wang, Jin, Lin, Zongtao, Lu, Yan, Li, Zhenmei, White, Stephen W., Miller, Duane D., Li, Wei
Publicado 2015

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

por Jones, Jeremy C., Kumar, Gyanendra, Barman, Subrata, Najera, Isabel, White, Stephen W., Webby, Richard J., Govorkova, Elena A.
Publicado 2018

Author Correction for Jones et al., “Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors”

por Jones, Jeremy C., Kumar, Gyanendra, Barman, Subrata, Najera, Isabel, White, Stephen W., Webby, Richard J., Govorkova, Elena A.
Publicado 2018

The phage T4 MotA transcription factor contains a novel DNA binding motif that specifically recognizes modified DNA

por Cuypers, Maxime G, Robertson, Rosanna M, Knipling, Leslie, Waddell, M Brett, Moon, Kyung, Hinton, Deborah M, White, Stephen W
Publicado 2018

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

por Carcelli, Mauro, Rogolino, Dominga, Gatti, Anna, De Luca, Laura, Sechi, Mario, Kumar, Gyanendra, White, Stephen W., Stevaert, Annelies, Naesens, Lieve
Publicado 2016

Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia

por Subramanian, Chitra, Frank, Matthew W., Tangallapally, Rajendra, Yun, Mi‐Kyung, White, Stephen W., Lee, Richard E., Rock, Charles O., Jackowski, Suzanne
Publicado 2022

LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators

por Sharma, Lalit Kumar, Yun, Mi Kyung, Subramanian, Chitra, Tangallapally, Rajendra, Jackowski, Suzanne, Rock, Charles O., White, Stephen W., Lee, Richard E.
Publicado 2021

Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes

por Gullett, Jessica M., Cuypers, Maxime G., Grace, Christy R., Pant, Shashank, Subramanian, Chitra, Tajkhorshid, Emad, Rock, Charles O., White, Stephen W.
Publicado 2022

A therapeutic approach to pantothenate kinase associated neurodegeneration

por Sharma, Lalit Kumar, Subramanian, Chitra, Yun, Mi-Kyung, Frank, Matthew W., White, Stephen W., Rock, Charles O., Lee, Richard E., Jackowski, Suzanne
Publicado 2018

Visualization of a substrate‐induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O‐acetylesterase reveals mechanistic conservation in...

por Williams, Allison H., Veyrier, Frédéric J., Bonis, Mathilde, Michaud, Yann, Raynal, Bertrand, Taha, Muhamed‐Kheir, White, Stephen W., Haouz, Ahmed, Boneca, Ivo G.
Publicado 2014

Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease

por Beylkin, Diane, Kumar, Gyanendra, Zhou, Wei, Park, Jaehyeon, Jeevan, Trushar, Lagisetti, Chandraiah, Harfoot, Rhodri, Webby, Richard J., White, Stephen W., Webb, Thomas R.
Publicado 2017

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

por DuBois, Rebecca M., Slavish, P. Jake, Baughman, Brandi M., Yun, Mi-Kyung, Bao, Ju, Webby, Richard J., Webb, Thomas R., White, Stephen W.
Publicado 2012

Identification and Characterization of an Allosteric Inhibitory Site on Dihydropteroate Synthase

por Hammoudeh, Dalia I., Daté, Mihir, Yun, Mi-Kyung, Zhang, Weixing, Boyd, Vincent A., Viacava Follis, Ariele, Griffith, Elizabeth, Lee, Richard E., Bashford, Donald, White, Stephen W.
Publicado 2014