Clinical Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Anifrolumab

por Tang, Weifeng, Tummala, Raj, Almquist, Joachim, Hwang, Michael, White, Wendy I., Boulton, David W., MacDonald, Alexander
Publicado 2023

Pharmacodynamic biomarkers and differential effects of TNF‐ and GM‐CSF‐targeting biologics in rheumatoid arthritis

por Guo, Xiang, Wang, Shiliang, Godwood, Alex, Close, David, Ryan, Patricia C., Roskos, Lorin K., White, Wendy I.
Publicado 2018

Nonlinear Population Pharmacokinetics of Anifrolumab in Healthy Volunteers and Patients With Systemic Lupus Erythematosus

por Almquist, Joachim, Kuruvilla, Denison, Mai, Tu, Tummala, Raj, White, Wendy I., Tang, Weifeng, Roskos, Lorin, Chia, Yen Lin
Publicado 2022

Suppression of soluble T cell-associated proteins by an anti-interferon-α monoclonal antibody in adult patients with dermatomyositis or polymyositis

por Guo, Xiang, Higgs, Brandon W., Rebelatto, Marlon, Zhu, Wei, Greth, Warren, Yao, Yihong, Roskos, Lorin K., White, Wendy I.
Publicado 2014

Relationship Between Anifrolumab Pharmacokinetics, Pharmacodynamics, and Efficacy in Patients With Moderate to Severe Systemic Lupus Erythematosus

por Chia, Yen Lin, Tummala, Raj, Mai, Tu H., Rouse, Tomas, Streicher, Katie, White, Wendy I., Morand, Eric F., Furie, Richard A.
Publicado 2022

Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE

por Casey, Kerry A, Guo, Xiang, Smith, Michael A, Wang, Shiliang, Sinibaldi, Dominic, Sanjuan, Miguel A, Wang, Liangwei, Illei, Gabor G, White, Wendy I
Publicado 2018

Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects...

por Parker, Joseph M, Oh, Chad K, LaForce, Craig, Miller, S David, Pearlman, David S, Le, Chenxiong, Robbie, Gabriel J, White, Wendy I, White, Barbara, Molfino, Nestor A
Publicado 2011

Urinary markers differentially associate with kidney inflammatory activity and chronicity measures in patients with lupus nephritis

por Akhgar, Ahmad, Sinibaldi, Dominic, Zeng, Lingmin, Farris, Alton B, Cobb, Jason, Battle, Monica, Chain, David, Cann, Jennifer A, Illei, Gábor G, Lim, S Sam, White, Wendy I
Publicado 2023

Storage Conditions of Conjugated Reagents Can Impact Results of Immunogenicity Assays

por Kubiak, Robert J., Lee, Nancy, Zhu, Yuan, Franch, William R., Levitskaya, Sophia V., Krishnan, Surekha R., Abraham, Varghese, Akufongwe, Peter F., Larkin, Christopher J., White, Wendy I.
Publicado 2016

A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis

por Weinblatt, Michael E., McInnes, Iain B., Kremer, Joel M., Miranda, Pedro, Vencovsky, Jiri, Guo, Xiang, White, Wendy I., Ryan, Patricia C., Godwood, Alex, Albulescu, Marius, Close, David, Burmester, Gerd R.
Publicado 2017

Sifalimumab, a Human Anti–Interferon-α Monoclonal Antibody, in Systemic Lupus Erythematosus: A Phase I Randomized, Controlled, Dose-Escalation Study: A Phase I Randomized, Controll...

por Petri, Michelle, Wallace, Daniel J, Spindler, Alberto, Chindalore, Vishala, Kalunian, Kenneth, Mysler, Eduardo, Neuwelt, C Michael, Robbie, Gabriel, White, Wendy I, Higgs, Brandon W, Yao, Yihong, Wang, Liangwei, Ethgen, Dominique, Greth, Warren
Publicado 2013

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyosi...

por Higgs, Brandon W, Zhu, Wei, Morehouse, Chris, White, Wendy I, Brohawn, Philip, Guo, Xiang, Rebelatto, Marlon, Le, Chenxiong, Amato, Anthony, Fiorentino, David, Greenberg, Steven A, Drappa, Jorn, Richman, Laura, Greth, Warren, Jallal, Bahija, Yao, Yihong
Publicado 2014

Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus

por Smith, Michael A., Chiang, Chia-Chien, Zerrouki, Kamelia, Rahman, Saifur, White, Wendy I., Streicher, Katie, Rees, William A., Schiffenbauer, Adam, Rider, Lisa G., Miller, Frederick W., Manna, Zerai, Hasni, Sarfaraz, Kaplan, Mariana J., Siegel, Richard, Sinibaldi, Dominic, Sanjuan, Miguel A., Casey, Kerry A.
Publicado 2020