PINK1 signalling in neurodegenerative disease

por Whiten, Daniel R., Cox, Dezerae, Sue, Carolyn M.
Publicado 2021

Single cell morphology distinguishes genotype and drug effect in Hereditary Spastic Paraplegia

por Wali, Gautam, Berkovsky, Shlomo, Whiten, Daniel R., Mackay-Sim, Alan, Sue, Carolyn M.
Publicado 2021

Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers

por Sanchez, Santiago Enrique, Whiten, Daniel R., Meisl, Georg, Ruggeri, Francesco Simone, Hidari, Eric, Klenerman, David
Publicado 2021

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides

por Konč, Juraj, Brown, Libby, Whiten, Daniel R., Zuo, Yukun, Ravn, Peter, Klenerman, David, Bernardes, Gonçalo J. L.
Publicado 2021

Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons

por Whiten, Daniel R, Brownjohn, Philip W, Moore, Steven, De, Suman, Strano, Alessio, Zuo, Yukun, Haneklaus, Moritz, Klenerman, David, Livesey, Frederick J
Publicado 2020

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

por West, Jennifer, Satapathy, Sandeep, Whiten, Daniel R., Kelly, Megan, Geraghty, Nicholas J., Proctor, Emma-Jayne, Sormanni, Pietro, Vendruscolo, Michele, Buxbaum, Joel N., Ranson, Marie, Wilson, Mark R.
Publicado 2021

Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease

por Lobanova, Evgeniia, Whiten, Daniel, Ruggeri, Francesco S, Taylor, Christopher G, Kouli, Antonina, Xia, Zengjie, Emin, Derya, Zhang, Yu P, Lam, Jeff Y L, Williams-Gray, Caroline H, Klenerman, David
Publicado 2021

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

por Whiten, Daniel R., Cox, Dezerae, Horrocks, Mathew H., Taylor, Christopher G., De, Suman, Flagmeier, Patrick, Tosatto, Laura, Kumita, Janet R., Ecroyd, Heath, Dobson, Christopher M., Klenerman, David, Wilson, Mark R.
Publicado 2018

Quantifying Co-Oligomer Formation by α-Synuclein

por Iljina, Marija, Dear, Alexander J., Garcia, Gonzalo A., De, Suman, Tosatto, Laura, Flagmeier, Patrick, Whiten, Daniel R., Michaels, Thomas C. T., Frenkel, Daan, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David
Publicado 2018

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

por Scheidt, Tom, Łapińska, Urszula, Kumita, Janet R., Whiten, Daniel R., Klenerman, David, Wilson, Mark R., Cohen, Samuel I. A., Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J., Arosio, Paolo
Publicado 2019

Clusterin protects neurons against intracellular proteotoxicity

por Gregory, Jenna M., Whiten, Daniel R., Brown, Rebecca A., Barros, Teresa P., Kumita, Janet R., Yerbury, Justin J., Satapathy, Sandeep, McDade, Karina, Smith, Colin, Luheshi, Leila M., Dobson, Christopher M., Wilson, Mark R.
Publicado 2017

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

por De, Suman, Wirthensohn, David C., Flagmeier, Patrick, Hughes, Craig, Aprile, Francesco A., Ruggeri, Francesco S., Whiten, Daniel R., Emin, Derya, Xia, Zengjie, Varela, Juan A., Sormanni, Pietro, Kundel, Franziska, Knowles, Tuomas P. J., Dobson, Christopher M., Bryant, Clare, Vendruscolo, Michele, Klenerman, David
Publicado 2019

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

por De, Suman, Whiten, Daniel R., Ruggeri, Francesco S., Hughes, Craig, Rodrigues, Margarida, Sideris, Dimitrios I., Taylor, Christopher G., Aprile, Francesco A., Muyldermans, Serge, Knowles, Tuomas P. J., Vendruscolo, Michele, Bryant, Clare, Blennow, Kaj, Skoog, Ingmar, Kern, Silke, Zetterberg, Henrik, Klenerman, David
Publicado 2019

Inhibiting the Ca(2+) Influx Induced by Human CSF

por Drews, Anna, De, Suman, Flagmeier, Patrick, Wirthensohn, David C., Chen, Wei-Hsin, Whiten, Daniel R., Rodrigues, Margarida, Vincke, Cécile, Muyldermans, Serge, Paterson, Ross W., Slattery, Catherine F., Fox, Nick C., Schott, Jonathan M., Zetterberg, Henrik, Dobson, Christopher M., Gandhi, Sonia, Klenerman, David
Publicado 2017

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

por Whiten, Daniel R., Zuo, Yukun, Calo, Laura, Choi, Minee‐Liane, De, Suman, Flagmeier, Patrick, Wirthensohn, David C., Kundel, Franziska, Ranasinghe, Rohan T., Sanchez, Santiago E., Athauda, Dilan, Lee, Steven F., Dobson, Christopher M., Gandhi, Sonia, Spillantini, Maria‐Grazia, Klenerman, David, Horrocks, Mathew H.
Publicado 2018

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

por Ludtmann, Marthe H. R., Angelova, Plamena R., Horrocks, Mathew H., Choi, Minee L., Rodrigues, Margarida, Baev, Artyom Y., Berezhnov, Alexey V., Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T., Whiten, Daniel R., Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J., Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Publicado 2018