Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy

por Michaels, Samantha A., Hulverson, Matthew A., Whitman, Grant R., Tran, Linh T., Choi, Ryan, Fan, Erkang, McNamara, Case W., Love, Melissa S., Ojo, Kayode K.
Publicado 2022

Reduced treatment frequencies with bumped kinase inhibitor 1369 are effective against porcine cystoisosporosis

por Shrestha, Aruna, Ruttkowski, Bärbel, Greber, Patricia, Whitman, Grant R., Hulverson, Matthew A., Choi, Ryan, Michaels, Samantha A., Ojo, Kayode K., Van Voorhis, Wesley C., Joachim, Anja
Publicado 2020

Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum

por Hennessey, Kelly M., Rogiers, Ilse C., Shih, Han-Wei, Hulverson, Matthew A., Choi, Ryan, McCloskey, Molly C., Whitman, Grant R., Barrett, Lynn K., Merritt, Ethan A., Paredez, Alexander R., Ojo, Kayode K.
Publicado 2018

P-Glycoprotein–Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium

por Arnold, Samuel L M, Choi, Ryan, Hulverson, Matthew A, Whitman, Grant R, Mccloskey, Molly C, Dorr, Carlie S, Vidadala, Rama S R, Khatod, Mansi, Morada, Mary, Barrett, Lynn K, Maly, Dustin J, Yarlett, Nigel, Van Voorhis, Wesley C
Publicado 2019

In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzo...

por Imhof, Dennis, Anghel, Nicoleta, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, Hänggeli, Kai, Choi, Ryan, Hulverson, Matthew A., Whitman, Grant R., Arnold, Samuel L.M., Ojo, Kayode K., Van Voorhis, Wesley C., Doggett, J. Stone, Ortega-Mora, Luis M., Hemphill, Andrew
Publicado 2021

Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo

por Anghel, Nicoleta, Imhof, Dennis, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, Haenggeli, Kai, Choi, Ryan, Hulverson, Matthew A., Whitman, Grant R., Arnold, Samuel L.M., Ojo, Kayode K., Van Voorhis, Wesley C., Doggett, J. Stone, Ortega-Mora, Luis M., Hemphill, Andrew
Publicado 2021

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

por Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.
Publicado 2017

Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro

por Shrestha, Aruna, Ojo, Kayode K., Koston, Florian, Ruttkowski, Bärbel, Vidadala, Rama S.R., Dorr, Carlie S., Navaluna, Edelmar D., Whitman, Grant R., Barrett, Kayleigh F., Barrett, Lynn K., Hulverson, Matthew A., Choi, Ryan, Michaels, Samantha A., Maly, Dustin J., Hemphill, Andrew, Van Voorhis, Wesley C., Joachim, Anja
Publicado 2019

A short-term treatment with BKI-1294 does not protect foetuses from sheep experimentally infected with Neospora caninum tachyzoites during pregnancy

por Sánchez-Sánchez, Roberto, Ferre, Ignacio, Re, Michela, Pérez-Arroyo, Bárbara, Cleofé-Resta, Darío, García, Victor Herrero, Díaz, Manuel Pizarro, Ferrer, Luis Miguel, Ruiz, Hector, Vallejo-García, Raquel, Benavides, Julio, Hulverson, Matthew A., Choi, Ryan, Whitman, Grant R., Hemphill, Andrew, Van Voorhis, Wesley C., Ortega-Mora, Luis Miguel
Publicado 2021

Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites

por Sánchez-Sánchez, Roberto, Ferre, Ignacio, Re, Michela, Vázquez, Patricia, Ferrer, Luis Miguel, Blanco-Murcia, Javier, Regidor-Cerrillo, Javier, Pizarro Díaz, Manuel, González-Huecas, Marta, Tabanera, Enrique, García-Lunar, Paula, Benavides, Julio, Castaño, Pablo, Hemphill, Andrew, Hulverson, Matthew A., Whitman, Grant R., Rivas, Kasey L., Choi, Ryan, Ojo, Kayode K., Barrett, Lynn K., Van Voorhis, Wesley C., Ortega-Mora, Luis Miguel
Publicado 2018

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis

por Hulverson, Matthew A., Choi, Ryan, Schaefer, Deborah A., Betzer, Dana P., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Lee, Sangun, Pranata, Andy, McLeod, Malcolm D., Marsh, Kennan C., Kempf, Dale J., LeRoy, Bruce E., Zafiratos, Mark T., Bielinski, Aimee L., Hackman, Robert C., Ojo, Kayode K., Arnold, Samuel L. M., Barrett, Lynn K., Tzipori, Saul, Riggs, Michael W., Fan, Erkang, Van Voorhis, Wesley C.
Publicado 2023