Efficacy of Lefamulin Against Staphylococcus aureus-Induced Bacteremia in a Neutropenic and Immunocompetent Murine Model

por Fischer, Evelin, Kappes, Barbara C, Wicha, Wolfgang W
Publicado 2017

Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumoniae

por Wicha, Wolfgang W, Strickmann, Dirk B, Paukner, Susanne
Publicado 2019

In vivo pharmacodynamics of lefamulin, the first systemic pleuromutilin for human use, in a neutropenic murine thigh infection model

por Wicha, Wolfgang W, Craig, William A, Andes, David
Publicado 2019

Tissue Distribution of [(14)C]-Lefamulin into the Urogenital Tract in Rats

por Wicha, Wolfgang W., Henson, Claire, Webbley, Kathryn, Gelone, Steven P.
Publicado 2022

Prediction of lefamulin epithelial lining fluid penetration after intravenous and oral administration using Phase 1 data and population pharmacokinetics methods

por Zhang, Li, Wicha, Wolfgang W, Bhavnani, Sujata M, Rubino, Christopher M
Publicado 2019

Pharmacokinetics and tolerability of lefamulin following intravenous and oral dosing

por Wicha, Wolfgang W, Prince, William T, Lell, Claudia, Heilmayer, Werner, Gelone, Steven P
Publicado 2019

Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse model

por Hafner, Michael, Paukner, Susanne, Wicha, Wolfgang W., Hrvačić, Boška, Cedilak, Matea, Faraho, Ivan, Gelone, Steven P.
Publicado 2021

LB6. Oral Lefamulin Is Safe and Effective in the Treatment of Adults With Community-Acquired Bacterial Pneumonia (CABP): Results of Lefamulin Evaluation Against Pneumonia (LEAP 2)...

por Alexander, Elizabeth, Goldberg, Lisa, Das, Anita, Moran, Gregory J, Sandrock, Christian, Gasink, Leanne B, Spera, Patricia, Sweeney, Carolyn, Paukner, Susanne, Wicha, Wolfgang W, Schranz, Jennifer
Publicado 2018

Pharmacokinetic/pharmacodynamic target attainment analyses to support intravenous and oral lefamulin dose selection for the treatment of patients with community-acquired bacterial...

por Bhavnani, Sujata M, Zhang, Li, Hammel, Jeffrey P, Rubino, Christopher M, Bader, Justin C, Sader, Helio S, Gelone, Steven P, Wicha, Wolfgang W, Ambrose, Paul G
Publicado 2019

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Ag...

por File, Thomas M, Goldberg, Lisa, Das, Anita, Sweeney, Carolyn, Saviski, John, Gelone, Steven P, Seltzer, Elyse, Paukner, Susanne, Wicha, Wolfgang W, Talbot, George H, Gasink, Leanne B
Publicado 2019

Erratum to: Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin E...

por File, Thomas M, Goldberg, Lisa, Das, Anita, Sweeney, Carolyn, Saviski, John, Gelone, Steven P, Seltzer, Elyse, Paukner, Susanne, Wicha, Wolfgang W, Talbot, George H, Gasink, Leanne B
Publicado 2020

Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating Neisseria gonorrhoeae infections

por Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Wicha, Wolfgang W., da Costa, Renata Maria Augusto, Franceschi, Francois, Brown, David, Louie, Arnold, Gelone, Steven P., Drusano, George, Unemo, Magnus
Publicado 2022