Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant Pseudomonas aeruginosa and Minimize Biofilm Formation

por Wickremasinghe, Hasini, Yu, Heidi H., Azad, Mohammad A. K., Zhao, Jinxin, Bergen, Phillip J., Velkov, Tony, Zhou, Qi Tony, Zhu, Yan, Li, Jian
Publicado 2021

Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase–Producing Klebsiella pneumoniae

por Lu, Jing, Han, Meiling, Yu, Heidi H., Bergen, Phillip J., Liu, Yiyun, Zhao, Jinxin, Wickremasinghe, Hasini, Jiang, Xukai, Hu, Yang, Du, Haiyan, Zhu, Yan, Velkov, Tony
Publicado 2023

An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates

por Patil, Nitin A., Thombare, Varsha J., Li, Rong, He, Xiaoji, Lu, Jing, Yu, Heidi H., Wickremasinghe, Hasini, Pamulapati, Kavya, Azad, Mohammad A. K., Velkov, Tony, Roberts, Kade D., Li, Jian
Publicado 2022

Metabolic Perturbations Caused by the Over-Expression of mcr-1 in Escherichia coli

por Liu, Yi-Yun, Zhu, Yan, Wickremasinghe, Hasini, Bergen, Phillip J., Lu, Jing, Zhu, Xiao-Qing, Zhou, Qiao-Li, Azad, Mohammad, Nang, Sue C., Han, Mei-Ling, Lei, Tao, Li, Jian, Liu, Jian-Hua
Publicado 2020

Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination

por Han, Mei-Ling, Nang, Sue C., Lin, Yu-Wei, Zhu, Yan, Yu, Heidi H., Wickremasinghe, Hasini, Barlow, Christopher K., Creek, Darren J., Crawford, Simon, Rao, Gauri, Dai, Chongshan, Barr, Jeremy J., Chan, Kim, Turner Schooley, Robert, Velkov, Tony, Li, Jian
Publicado 2022

A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

por Jiang, Xukai, Patil, Nitin A., Azad, Mohammad A. K., Wickremasinghe, Hasini, Yu, Heidi, Zhao, Jinxin, Zhang, Xinru, Li, Mengyao, Gong, Bin, Wan, Lin, Ma, Wendong, Thompson, Philip E., Yang, Kai, Yuan, Bing, Schreiber, Falk, Wang, Lushan, Velkov, Tony, Roberts, Kade D., Li, Jian
Publicado 2021

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity

por Lu, Jing, Azad, Mohammad A. K., Moreau, Julie L. M., Zhu, Yan, Jiang, Xukai, Tonta, Mary, Lam, Rachel, Wickremasinghe, Hasini, Zhao, Jinxin, Wang, Jiping, Coleman, Harold A., Formosa, Luke E., Velkov, Tony, Parkington, Helena C., Combes, Alexander N., Rosenbluh, Joseph, Li, Jian
Publicado 2022