Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy

por Widjaja, Anissa A., Chothani, Sonia P., Cook, Stuart A.
Publicado 2020

The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

por Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Schafer, Sebastian, Kuthubudeen, Fathima F, Widjaja, Anissa A, Cook, Stuart A
Publicado 2021

IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues

por Widjaja, Anissa A., Chothani, Sonia, Viswanathan, Sivakumar, Goh, Joyce Wei Ting, Lim, Wei-Wen, Cook, Stuart A.
Publicado 2022

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

por Widjaja, Anissa A., Viswanathan, Sivakumar, Wei Ting, Joyce Goh, Tan, Jessie, Shekeran, Shamini G., Carling, David, Lim, Wei-Wen, Cook, Stuart A.
Publicado 2022

Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice

por Lim, Wei-Wen, Ng, Benjamin, Widjaja, Anissa, Xie, Chen, Su, Liping, Ko, Nicole, Lim, Sze-Yun, Kwek, Xiu-Yi, Lim, Stella, Cook, Stuart Alexander, Schafer, Sebastian
Publicado 2020

Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction

por Sweeney, Mark, O’Fee, Katie, Villanueva-Hayes, Chelsie, Rahman, Ekhlas, Lee, Michael, Vanezis, Konstantinos, Andrew, Ivan, Lim, Wei-Wen, Widjaja, Anissa, Barton, Paul J. R., Cook, Stuart A.
Publicado 2023

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury

por Dong, Jinrui, Lim, Wei-Wen, Shekeran, Shamini G., Tan, Jessie, Lim, Sze Yun, Goh, Joyce Wei Ting, George, Benjamin L., Schafer, Sebastian, Cook, Stuart A., Widjaja, Anissa A.
Publicado 2022

Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression

por Zhou, Jin, Pang, Jeremy, Tripathi, Madhulika, Ho, Jia Pei, Widjaja, Anissa Anindya, Shekeran, Shamini Guna, Cook, Stuart Alexander, Suzuki, Ayako, Diehl, Anna Mae, Petretto, Enrico, Singh, Brijesh Kumar, Yen, Paul Michael
Publicado 2022

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

por Widjaja, Anissa A., Viswanathan, Sivakumar, Jinrui, Dong, Singh, Brijesh K., Tan, Jessie, Wei Ting, Joyce Goh, Lamb, David, Shekeran, Shamini G., George, Benjamin L., Schafer, Sebastian, Carling, David, Adami, Eleonora, Cook, Stuart A.
Publicado 2021

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis

por Ng, Benjamin, Viswanathan, Sivakumar, Widjaja, Anissa A., Lim, Wei-Wen, Shekeran, Shamini G., Goh, Joyce Wei Ting, Tan, Jessie, Kuthubudeen, Fathima, Lim, Sze Yun, Xie, Chen, Schafer, Sebastian, Adami, Eleonora, Cook, Stuart A.
Publicado 2022

Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis

por Ng, Benjamin, Widjaja, Anissa A., Viswanathan, Sivakumar, Dong, Jinrui, Chothani, Sonia P., Lim, Stella, Shekeran, Shamini G., Tan, Jessie, McGregor, Narelle E., Walker, Emma C., Sims, Natalie A., Schafer, Sebastian, Cook, Stuart A.
Publicado 2021

IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts

por Adami, Eleonora, Viswanathan, Sivakumar, Widjaja, Anissa A, Ng, Benjamin, Chothani, Sonia, Zhihao, Nevin, Tan, Jessie, Lio, Pei Min, George, Benjamin L, Altunoglu, Umut, Ghosh, Kakaly, Paleja, Bhairav S, Schafer, Sebastian, Reversade, Bruno, Albani, Salvatore, Ling, Andrea Low Hsiu, O'Reilly, Steven, Cook, Stuart A
Publicado 2021

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

por Widjaja, Anissa A., Viswanathan, Sivakumar, Shekeran, Shamini G., Adami, Eleonora, Lim, Wei-Wen, Chothani, Sonia, Tan, Jessie, Goh, Joyce Wei Ting, Chen, Hui Mei, Lim, Sze Yun, Boustany-Kari, Carine M., Hawkins, Julie, Petretto, Enrico, Hübner, Norbert, Schafer, Sebastian, Coffman, Thomas M., Cook, Stuart A.
Publicado 2022

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

por Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Singh, Brijesh K., Chothani, Sonia P., Ng, Benjamin, Lim, Wei Wen, Zhou, Jin, Tripathi, Madhulika, Ko, Nicole S. J., Shekeran, Shamini G., Tan, Jessie, Lim, Sze Yun, Wang, Mao, Lio, Pei Min, Yen, Paul M., Schafer, Sebastian, Cook, Stuart A., Widjaja, Anissa A.
Publicado 2021

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models

por Lim, Wei-Wen, Corden, Ben, Ng, Benjamin, Vanezis, Konstantinos, D’Agostino, Giuseppe, Widjaja, Anissa A., Song, Wei-Hua, Xie, Chen, Su, Liping, Kwek, Xiu-Yi, Tee, Nicole G. Z., Dong, Jinrui, Ko, Nicole S. J., Wang, Mao, Pua, Chee Jian, Jamal, Muhammad H., Soh, Beeyong, Viswanathan, Sivakumar, Schafer, Sebastian, Cook, Stuart A.
Publicado 2020

Wars2 is a determinant of angiogenesis

por Wang, Mao, Sips, Patrick, Khin, Ester, Rotival, Maxime, Sun, Ximing, Ahmed, Rizwan, Widjaja, Anissa Anindya, Schafer, Sebastian, Yusoff, Permeen, Choksi, Pervinder Kaur, Ko, Nicole Shi Jie, Singh, Manvendra K., Epstein, David, Guan, Yuguang, Houštěk, Josef, Mracek, Tomas, Nuskova, Hana, Mikell, Brittney, Tan, Jessie, Pesce, Francesco, Kolar, Frantisek, Bottolo, Leonardo, Mancini, Massimiliano, Hubner, Norbert, Pravenec, Michal, Petretto, Enrico, MacRae, Calum, Cook, Stuart A
Publicado 2016

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins

por Chothani, Sonia, Schäfer, Sebastian, Adami, Eleonora, Viswanathan, Sivakumar, Widjaja, Anissa A., Langley, Sarah R., Tan, Jessie, Wang, Mao, Quaife, Nicholas M., Jian Pua, Chee, D’Agostino, Giuseppe, Guna Shekeran, Shamini, George, Benjamin L., Lim, Stella, Yiqun Cao, Elaine, van Heesch, Sebastiaan, Witte, Franziska, Felkin, Leanne E., Christodoulou, Eleni G., Dong, Jinrui, Blachut, Susanne, Patone, Giannino, Barton, Paul J.R., Hubner, Norbert, Cook, Stuart A., Rackham, Owen J.L.
Publicado 2019