T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

por Fukushima, Atsushi, Loh, Kim, Galic, Sandra, Fam, Barbara, Shields, Ben, Wiede, Florian, Tremblay, Michel L., Watt, Matthew J., Andrikopoulos, Sofianos, Tiganis, Tony
Publicado 2010

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification

por Wiede, Florian, Dudakov, Jarrod A., Lu, Kun-Hui, Dodd, Garron T., Butt, Tariq, Godfrey, Dale I., Strasser, Andreas, Boyd, Richard L., Tiganis, Tony
Publicado 2017

Stepwise progression of β-selection during T cell development involves histone deacetylation

por Chann, Anchi S, Charnley, Mirren, Newton, Lucas M, Newbold, Andrea, Wiede, Florian, Tiganis, Tony, Humbert, Patrick O, Johnstone, Ricky W, Russell, Sarah M
Publicado 2022

Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis

por Bettaieb, Ahmed, Xi, Yannan, Hosein, Ellen, Coggins, Nicole, Bachaalany, Santana, Wiede, Florian, Perez, Salvador, Griffey, Stephen M, Sastre, Juan, Tiganis, Tony, Haj, Fawaz G
Publicado 2014

Strain-Dependent Differences in Bone Development, Myeloid Hyperplasia, Morbidity and Mortality in Ptpn2-Deficient Mice

por Wiede, Florian, Chew, Sock Hui, van Vliet, Catherine, Poulton, Ingrid J., Kyparissoudis, Konstantinos, Sasmono, Tedjo, Loh, Kim, Tremblay, Michel L., Godfrey, Dale I., Sims, Natalie A., Tiganis, Tony
Publicado 2012

PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

por Goh, Pei Kee, Wiede, Florian, Zeissig, Mara N., Britt, Kara L., Liang, Shuwei, Molloy, Tim, Goode, Nathan, Xu, Rachel, Loi, Sherene, Muller, Mathias, Humbert, Patrick O., McLean, Catriona, Tiganis, Tony
Publicado 2022

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

por Flosbach, Markus, Oberle, Susanne G., Scherer, Stefanie, Zecha, Jana, von Hoesslin, Madlaina, Wiede, Florian, Chennupati, Vijaykumar, Cullen, Jolie G., List, Markus, Pauling, Josch K., Baumbach, Jan, Kuster, Bernhard, Tiganis, Tony, Zehn, Dietmar
Publicado 2020

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

por Liang, Shuwei, Tran, Eric, Du, Xin, Dong, Jiajun, Sudholz, Harrison, Chen, Hao, Qu, Zihan, Huntington, Nicholas D., Babon, Jeffrey J., Kershaw, Nadia J., Zhang, Zhong-Yin, Baell, Jonathan B., Wiede, Florian, Tiganis, Tony
Publicado 2023

PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity

por Wiede, Florian, Lu, Kun-Hui, Du, Xin, Zeissig, Mara N., Xu, Rachel, Goh, Pei Kee, Xirouchaki, Chrysovalantou E., Hogarth, Samuel J., Greatorex, Spencer, Sek, Kevin, Daly, Roger J., Beavis, Paul A., Darcy, Phillip K., Tonks, Nicholas K., Tiganis, Tony
Publicado 2022

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

por Grohmann, Marcus, Wiede, Florian, Dodd, Garron T., Gurzov, Esteban N., Ooi, Geraldine J., Butt, Tariq, Rasmiena, Aliki A., Kaur, Supreet, Gulati, Twishi, Goh, Pei K., Treloar, Aislinn E., Archer, Stuart, Brown, Wendy A., Muller, Mathias, Watt, Matthew J., Ohara, Osamu, McLean, Catriona A., Tiganis, Tony
Publicado 2018

PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours

por Wiede, Florian, Lu, Kun‐Hui, Du, Xin, Liang, Shuwei, Hochheiser, Katharina, Dodd, Garron T, Goh, Pei K, Kearney, Conor, Meyran, Deborah, Beavis, Paul A, Henderson, Melissa A, Park, Simone L, Waithman, Jason, Zhang, Sheng, Zhang, Zhong‐Yin, Oliaro, Jane, Gebhardt, Thomas, Darcy, Phillip K, Tiganis, Tony
Publicado 2019

Activation of naïve CD4(+) T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4(+) T cells

por Twohig, Jason P., Figueras, Ana Cardus, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Soria, Alicia Derrac, Lewis, Myles J., Townsend, Michael J., Millrine, David, Li, Jasmine, Hill, David G., Fernandez, Javier Uceda, Liu, Xiao, Szomolay, Barbara, Pepper, Christopher J., Taylor, Philip R., Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M., Jones, Gareth W., Jones, Simon A.
Publicado 2019

Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8(+) T cells in skin

por Hochheiser, Katharina, Wiede, Florian, Wagner, Teagan, Freestone, David, Enders, Matthias H., Olshansky, Moshe, Russ, Brendan, Nüssing, Simone, Bawden, Emma, Braun, Asolina, Bachem, Annabell, Gressier, Elise, McConville, Robyn, Park, Simone L., Jones, Claerwen M., Davey, Gayle M., Gyorki, David E., Tscharke, David, Parish, Ian A., Turner, Stephen, Herold, Marco J., Tiganis, Tony, Bedoui, Sammy, Gebhardt, Thomas
Publicado 2021