Structure-based validation can drastically under-estimate error rate in proteome-wide cross-linking mass spectrometry studies

por Yugandhar, Kumar, Wang, Ting-Yi, Wierbowski, Shayne D., Shayhidin, Elnur Elyar, Yu, Haiyuan
Publicado 2020

A full-proteome, interaction-specific characterization of mutational hotspots across human cancers

por Chen, Siwei, Liu, Yuan, Zhang, Yingying, Wierbowski, Shayne D., Lipkin, Steven M., Wei, Xiaomu, Yu, Haiyuan
Publicado 2022

Transcription imparts architecture, function, and logic to enhancer units

por Tippens, Nathaniel D., Liang, Jin, King-Yung Leung, Alden, Wierbowski, Shayne D., Ozer, Abdullah, Booth, James G., Lis, John T., Yu, Haiyuan
Publicado 2020

A 3D Structural SARS-CoV-2-Human Interactome to Explore Genetic and Drug Perturbations

por Wierbowski, Shayne D., Liang, Siqi, Liu, Yuan, Chen, You, Gupta, Shagun, Andre, Nicole M., Lipkin, Steven M., Whittaker, Gary R., Yu, Haiyuan
Publicado 2021

A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19

por Zhou, Yadi, Liu, Yuan, Gupta, Shagun, Paramo, Mauricio I., Hou, Yuan, Mao, Chengsheng, Luo, Yuan, Judd, Julius, Wierbowski, Shayne, Bertolotti, Marta, Nerkar, Mriganka, Jehi, Lara, Drayman, Nir, Nicolaescu, Vlad, Gula, Haley, Tay, Savaş, Randall, Glenn, Lis, John T., Feschotte, Cédric, Erzurum, Serpil C., Cheng, Feixiong, Yu, Haiyuan
Publicado 2022

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

por Fragoza, Robert, Das, Jishnu, Wierbowski, Shayne D., Liang, Jin, Tran, Tina N., Liang, Siqi, Beltran, Juan F., Rivera-Erick, Christen A., Ye, Kaixiong, Wang, Ting-Yi, Yao, Li, Mort, Matthew, Stenson, Peter D., Cooper, David N., Wei, Xiaomu, Keinan, Alon, Schimenti, John C., Clark, Andrew G., Yu, Haiyuan
Publicado 2019