Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor Cells

por Wierenga, Albertus T. J., Vellenga, Edo, Schuringa, Jan Jacob
Publicado 2014

STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells

por Schepers, Hein, Wierenga, Albertus T.J., Vellenga, Edo, Schuringa, Jan Jacob
Publicado 2012

Single-Cell STAT5 Signal Transduction Profiling in Normal and Leukemic Stem and Progenitor Cell Populations Reveals Highly Distinct Cytokine Responses

por Han, Lina, Wierenga, Albertus T. J., Rozenveld-Geugien, Marjan, van de Lande, Kim, Vellenga, Edo, Schuringa, Jan Jacob
Publicado 2009

Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia

por Folkerts, Hendrik, Hilgendorf, Susan, Wierenga, Albertus T J, Jaques, Jennifer, Mulder, André B, Coffer, Paul J, Schuringa, Jan Jacob, Vellenga, Edo
Publicado 2017

Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis

por Folkerts, Hendrik, Wierenga, Albertus T., van den Heuvel, Fiona A., Woldhuis, Roy R., Kluit, Darlyne S., Jaques, Jennifer, Schuringa, Jan Jacob, Vellenga, Edo
Publicado 2019

Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation

por Sontakke, Pallavi, Koczula, Katarzyna M., Jaques, Jennifer, Wierenga, Albertus T. J., Brouwers-Vos, Annet Z., Pruis, Maurien, Günther, Ulrich L., Vellenga, Edo, Schuringa, Jan Jacob
Publicado 2016

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

por Wierenga, Albertus T. J., Cunningham, Alan, Erdem, Ayşegül, Lopera, Nuria Vilaplana, Brouwers-Vos, Annet Z., Pruis, Maurien, Mulder, André B., Günther, Ulrich L., Martens, Joost H. A., Vellenga, Edo, Schuringa, Jan Jacob
Publicado 2019

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

por Erdem, Ayşegül, Marin, Silvia, Pereira-Martins, Diego A., Geugien, Marjan, Cunningham, Alan, Pruis, Maurien G., Weinhäuser, Isabel, Gerding, Albert, Bakker, Barbara M., Wierenga, Albertus T. J., Rego, Eduardo M., Huls, Gerwin, Cascante, Marta, Schuringa, Jan Jacob
Publicado 2022

S127: DELTATP73 IMPOSES TP53 MUTANT-LIKE PHENOTYPES INCLUDING DRUG RESISTANCE AND POOR PROGNOSIS ON TP53-WILD TYPE ACUTE MYELOID LEUKEMIA.

por Pereira-Martins, Diego A, Alexander Ortiz Rojas, César, Weinhauser, Isabel, Silveira, Douglas, Wierenga, Albertus T J, van den Boom, Vincent, Bianco, Thiago M, Ammatuna, Emanuele, Quek, Lynn, Lucena-Araujo, Antonio R, Huls, Gerwin, Rego, Eduardo, Jacob Schuringa, Jan
Publicado 2023

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

por Erdem, Ayşegül, Marin, Silvia, Pereira-Martins, Diego A., Cortés, Roldán, Cunningham, Alan, Pruis, Maurien G., de Boer, Bauke, van den Heuvel, Fiona A. J., Geugien, Marjan, Wierenga, Albertus T. J., Brouwers-Vos, Annet Z., Rego, Eduardo M., Huls, Gerwin, Cascante, Marta, Schuringa, Jan Jacob
Publicado 2022

Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

por Yi, Guoqiang, Wierenga, Albertus T.J., Petraglia, Francesca, Narang, Pankaj, Janssen-Megens, Eva M., Mandoli, Amit, Merkel, Angelika, Berentsen, Kim, Kim, Bowon, Matarese, Filomena, Singh, Abhishek A., Habibi, Ehsan, Prange, Koen H.M., Mulder, André B., Jansen, Joop H., Clarke, Laura, Heath, Simon, van der Reijden, Bert A., Flicek, Paul, Yaspo, Marie-Laure, Gut, Ivo, Bock, Christoph, Schuringa, Jan Jacob, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.
Publicado 2019

Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia

por Singh, Abhishek A., Petraglia, Francesca, Nebbioso, Angela, Yi, Guoqiang, Conte, Mariarosaria, Valente, Sergio, Mandoli, Amit, Scisciola, Lucia, Lindeboom, Rik, Kerstens, Hinri, Janssen-Megens, Eva M., Pourfarzad, Farzin, Habibi, Ehsan, Berentsen, Kim, Kim, Bowon, Logie, Colin, Heath, Simon, Wierenga, Albertus T.J., Clarke, Laura, Flicek, Paul, Jansen, Joop H., Kuijpers, Taco, Yaspo, Marie Laure, Valle, Veronique Della, Bernard, Olivier, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G., Mai, Antonello, Altucci, Lucia, Martens, Joost H.A.
Publicado 2018

Combined HAT/EZH2 modulation leads to cancer-selective cell death

por Petraglia, Francesca, Singh, Abhishek A., Carafa, Vincenzo, Nebbioso, Angela, Conte, Mariarosaria, Scisciola, Lucia, Valente, Sergio, Baldi, Alfonso, Mandoli, Amit, Petrizzi, Valeria Belsito, Ingenito, Concetta, De Falco, Sandro, Cicatiello, Valeria, Apicella, Ivana, Janssen-Megens, Eva M., Kim, Bowon, Yi, Guoqiang, Logie, Colin, Heath, Simon, Ruvo, Menotti, Wierenga, Albertus T.J., Flicek, Paul, Yaspo, Marie Laure, Della Valle, Veronique, Bernard, Olivier, Tomassi, Stefano, Novellino, Ettore, Feoli, Alessandra, Sbardella, Gianluca, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G., Mai, Antonello, Martens, Joost H.A., Altucci, Lucia
Publicado 2018