The Role of Oxygen in Avascular Tumor Growth

por Grimes, David Robert, Kannan, Pavitra, McIntyre, Alan, Kavanagh, Anthony, Siddiky, Abul, Wigfield, Simon, Harris, Adrian, Partridge, Mike
Publicado 2016

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

por Ledaki, Ioanna, McIntyre, Alan, Wigfield, Simon, Buffa, Francesca, McGowan, Simon, Baban, Dilair, Li, Ji-liang, Harris, Adrian L.
Publicado 2015

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia

por Haider, Syed, McIntyre, Alan, van Stiphout, Ruud G. P. M., Winchester, Laura M., Wigfield, Simon, Harris, Adrian L., Buffa, Francesca M.
Publicado 2016

Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1

por Jonikas, Mindaugas, Madill, Martin, Mathy, Alexandre, Zekoll, Theresa, Zois, Christos E., Wigfield, Simon, Kurzawa‐Akanbi, Marzena, Browne, Cathy, Sims, David, Chinnery, Patrick F., Cowley, Sally A., Tofaris, George K.
Publicado 2018

Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells

por Chapman, Thomas P., Corridoni, Daniele, Shiraishi, Seiji, Pandey, Sumeet, Aulicino, Anna, Wigfield, Simon, do Carmo Costa, Maria, Thézénas, Marie-Laëtitia, Paulson, Henry, Fischer, Roman, Kessler, Benedikt M., Simmons, Alison
Publicado 2019

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

por Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.
Publicado 2004

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells

por Kawashima, Masahiro, Bensaad, Karim, Zois, Christos E., Barberis, Alessandro, Bridges, Esther, Wigfield, Simon, Lagerholm, Christoffer, Dmitriev, Ruslan I., Tokiwa, Mariko, Toi, Masakazu, Papkovsky, Dmitri B., Buffa, Francesca M., Harris, Adrian L.
Publicado 2020

Correction to: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells

por Kawashima, Masahiro, Bensaad, Karim, Zois, Christos E., Barberis, Alessandro, Bridges, Esther, Wigfield, Simon, Lagerholm, Christoffer, Dmitriev, Ruslan I., Tokiwa, Mariko, Toi, Masakazu, Papkovsky, Dmitri B., Buffa, Francesca M., Harris, Adrian L.
Publicado 2020

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

por Morotti, Matteo, Bridges, Esther, Valli, Alessandro, Choudhry, Hani, Sheldon, Helen, Wigfield, Simon, Gray, Nicki, Zois, Christos E., Grimm, Fiona, Jones, Dylan, Teoh, Eugene J., Cheng, Wei-Chen, Lord, Simon, Anastasiou, Dimitrios, Haider, Syed, McIntyre, Alan, Goberdhan, Deborah C. I., Buffa, Francesca, Harris, Adrian L.
Publicado 2019

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin

por Lord, Simon R., Collins, Jennifer M., Cheng, Wei-Chen, Haider, Syed, Wigfield, Simon, Gaude, Edoardo, Fielding, Barbara A., Pinnick, Katherine E., Harjes, Ulrike, Segaran, Ashvina, Jha, Pooja, Hoefler, Gerald, Pollak, Michael N., Thompson, Alastair M., Roy, Pankaj G., English, Ruth., Adams, Rosie F., Frezza, Christian, Buffa, Francesca M., Karpe, Fredrik, Harris, Adrian L.
Publicado 2019

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer

por Lord, Simon R., Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J., Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R., Ah-See, Mei-Lin, Thompson, Alastair M., Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G., Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F., Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D., Buffa, Francesca M., Harris, Adrian L.
Publicado 2018