Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

por Morissette, Pierre, Polak, Sebastian, Chain, Anne, Zhai, Jin, Imredy, John P., Wildey, Mary Jo, Travis, Jeffrey, Fitzgerald, Kevin, Fanelli, Patrick, Passini, Elisa, Rodriguez, Blanca, Sannajust, Frederick, Regan, Christopher
Publicado 2020

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

por Coussens, Nathan P., Sittampalam, G. Sitta, Guha, Rajarshi, Brimacombe, Kyle, Grossman, Abigail, Chung, Thomas D. Y., Weidner, Jeffrey R., Riss, Terry, Trask, O. Joseph, Auld, Douglas, Dahlin, Jayme L., Devanaryan, Viswanath, Foley, Timothy L., McGee, James, Kahl, Steven D., Kales, Stephen C., Arkin, Michelle, Baell, Jonathan, Bejcek, Bruce, Gal‐Edd, Neely, Glicksman, Marcie, Haas, Joseph V., Iversen, Philip W., Hoeppner, Marilu, Lathrop, Stacy, Sayers, Eric, Liu, Hanguan, Trawick, Bart, McVey, Julie, Lemmon, Vance P., Li, Zhuyin, McManus, Owen, Minor, Lisa, Napper, Andrew, Wildey, Mary Jo, Pacifici, Robert, Chin, William W., Xia, Menghang, Xu, Xin, Lal‐Nag, Madhu, Hall, Matthew D., Michael, Sam, Inglese, James, Simeonov, Anton, Austin, Christopher P.
Publicado 2018