Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

por Hall, Belinda S., Bot, Christopher, Wilkinson, Shane R.
Publicado 2011

The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence

por Taylor, Martin C., Lewis, Michael D., Francisco, Amanda Fortes, Wilkinson, Shane R., Kelly, John M.
Publicado 2015

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds

por Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Publicado 2016

Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity

por Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Publicado 2016

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

por Meredith, Emma Louise, Kumar, Ambika, Konno, Aya, Szular, Joanna, Alsford, Sam, Seifert, Karin, Horn, David, Wilkinson, Shane R.
Publicado 2017

Challenges in Chagas Disease Drug Development

por Francisco, Amanda F., Jayawardhana, Shiromani, Olmo, Francisco, Lewis, Michael D., Wilkinson, Shane R., Taylor, Martin C., Kelly, John M.
Publicado 2020

Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

por Mejia, Ana Maria, Hall, Belinda S., Taylor, Martin C., Gómez-Palacio, Andrés, Wilkinson, Shane R., Triana-Chávez, Omar, Kelly, John M.
Publicado 2012

Preclinical Studies in Anti-Trypanosomatidae Drug Development

por Perdomo, Cintya, Aguilera, Elena, Corvo, Ileana, Faral-Tello, Paula, Serna, Elva, Robello, Carlos, Wilkinson, Shane R., Yaluff, Gloria, Alvarez, Guzmán
Publicado 2021

Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages

por Schnick, Claudia, Polley, Spencer D, Fivelman, Quinton L, Ranford-Cartwright, Lisa C, Wilkinson, Shane R, Brannigan, James A, Wilkinson, Anthony J, Baker, David A
Publicado 2009

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

por Shameer, Sanu, Logan-Klumpler, Flora J., Vinson, Florence, Cottret, Ludovic, Merlet, Benjamin, Achcar, Fiona, Boshart, Michael, Berriman, Matthew, Breitling, Rainer, Bringaud, Frédéric, Bütikofer, Peter, Cattanach, Amy M., Bannerman-Chukualim, Bridget, Creek, Darren J., Crouch, Kathryn, de Koning, Harry P., Denise, Hubert, Ebikeme, Charles, Fairlamb, Alan H., Ferguson, Michael A. J., Ginger, Michael L., Hertz-Fowler, Christiane, Kerkhoven, Eduard J., Mäser, Pascal, Michels, Paul A. M., Nayak, Archana, Nes, David W., Nolan, Derek P., Olsen, Christian, Silva-Franco, Fatima, Smith, Terry K., Taylor, Martin C., Tielens, Aloysius G. M., Urbaniak, Michael D., van Hellemond, Jaap J., Vincent, Isabel M., Wilkinson, Shane R., Wyllie, Susan, Opperdoes, Fred R., Barrett, Michael P., Jourdan, Fabien
Publicado 2014