Does WAVE1 contain a GoLoco/GPR motif?

por Willard, Francis S.
Publicado 2006

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

por Siderovski, David P., Willard, Francis S.
Publicado 2005

Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor

por Willard, Francis S., Sloop, Kyle W.
Publicado 2012

Small Molecule Drug Discovery at the Glucagon-Like Peptide-1 Receptor

por Willard, Francis S., Bueno, Ana B., Sloop, Kyle W.
Publicado 2012

Activation of Endogenous Thrombin Receptors Causes Clustering and Sensitization of Epidermal Growth Factor Receptors of Swiss 3t3 Cells without Transactivation

por Crouch, Michael F., Davy, Deborah A., Willard, Francis S., Berven, Leise A.
Publicado 2001

Glucagon-Like Peptide-1 Receptor Ligand Interactions: Structural Cross Talk between Ligands and the Extracellular Domain

por West, Graham M., Willard, Francis S., Sloop, Kyle W., Showalter, Aaron D., Pascal, Bruce D., Griffin, Patrick R.
Publicado 2014

A P-loop Mutation in Gα Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis

por Bosch, Dustin E., Willard, Francis S., Ramanujam, Ravikrishna, Kimple, Adam J., Willard, Melinda D., Naqvi, Naweed I., Siderovski, David P.
Publicado 2012

Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica

por Bosch, Dustin E., Kimple, Adam J., Muller, Robin E., Giguère, Patrick M., Machius, Mischa, Willard, Francis S., Temple, Brenda R. S., Siderovski, David P.
Publicado 2012

Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles

por Bueno, Ana B., Showalter, Aaron D., Wainscott, David B., Stutsman, Cynthia, Marín, Aranzazu, Ficorilli, James, Cabrera, Over, Willard, Francis S., Sloop, Kyle W.
Publicado 2016

Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector

por Willard, Francis S., Willard, Melinda D., Kimple, Adam J., Soundararajan, Meera, Oestreich, Emily A., Li, Xiaoyan, Sowa, Nathaniel A., Kimple, Randall J., Doyle, Declan A., Der, Channing J., Zylka, Mark J., Snider, William D., Siderovski, David P.
Publicado 2009

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets

por Sloop, Kyle W., Willard, Francis S., Brenner, Martin B., Ficorilli, James, Valasek, Kathleen, Showalter, Aaron D., Farb, Thomas B., Cao, Julia X.C., Cox, Amy L., Michael, M. Dodson, Gutierrez Sanfeliciano, Sonia Maria, Tebbe, Mark J., Coghlan, Michael J.
Publicado 2010

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

por Kawai, Takahiro, Sun, Bingfa, Yoshino, Hitoshi, Feng, Dan, Suzuki, Yoshiyuki, Fukazawa, Masanori, Nagao, Shunsuke, Wainscott, David B., Showalter, Aaron D., Droz, Brian A., Kobilka, Tong Sun, Coghlan, Matthew P., Willard, Francis S., Kawabe, Yoshiki, Kobilka, Brian K., Sloop, Kyle W.
Publicado 2020

Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation

por Dey, Asim B., Khedr, Sherif, Bean, James, Porras, Leah L., Meredith, Tamika D., Willard, Francis S., Hass, Joseph V., Zhou, Xin, Terashvili, Maia, Jesudason, Cynthia D., Ruley, Kevin M., Wiley, Michael R., Kowala, Mark, Atkinson, Simon J., Staruschenko, Alexander, Rekhter, Mark D.
Publicado 2020

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

por El, Kimberley, Douros, Jonathan D., Willard, Francis S., Novikoff, Aaron, Sargsyan, Ashot, Perez-Tilve, Diego, Wainscott, David B., Yang, Bin, Chen, Alex, Wothe, Donald, Coupland, Callum, Tschöp, Mattias H., Finan, Brian, D’Alessio, David A., Sloop, Kyle W., Müller, Timo D., Campbell, Jonathan E.
Publicado 2023

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

por Lee, Jonathan A., Shinn, Paul, Jaken, Susan, Oliver, Sarah, Willard, Francis S., Heidler, Steven, Peery, Robert B., Oler, Jennifer, Chu, Shaoyou, Southall, Noel, Dexheimer, Thomas S., Smallwood, Jeffrey, Huang, Ruili, Guha, Rajarshi, Jadhav, Ajit, Cox, Karen, Austin, Christopher P., Simeonov, Anton, Sittampalam, G. Sitta, Husain, Saba, Franklin, Natalie, Wild, David J., Yang, Jeremy J., Sutherland, Jeffrey J., Thomas, Craig J.
Publicado 2015

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

por Willard, Francis S., Douros, Jonathan D., Gabe, Maria B.N., Showalter, Aaron D., Wainscott, David B., Suter, Todd M., Capozzi, Megan E., van der Velden, Wijnand J.C., Stutsman, Cynthia, Cardona, Guemalli R., Urva, Shweta, Emmerson, Paul J., Holst, Jens J., D’Alessio, David A., Coghlan, Matthew P., Rosenkilde, Mette M., Campbell, Jonathan E., Sloop, Kyle W.
Publicado 2020

Structural determinants of dual incretin receptor agonism by tirzepatide

por Sun, Bingfa, Willard, Francis S., Feng, Dan, Alsina-Fernandez, Jorge, Chen, Qi, Vieth, Michal, Ho, Joseph D., Showalter, Aaron D., Stutsman, Cynthia, Ding, Liyun, Suter, Todd M., Dunbar, James D., Carpenter, John W., Mohammed, Faiz Ahmad, Aihara, Eitaro, Brown, Robert A., Bueno, Ana B., Emmerson, Paul J., Moyers, Julie S., Kobilka, Tong Sun, Coghlan, Matthew P., Kobilka, Brian K., Sloop, Kyle W.
Publicado 2022