Mouse models of fragile X-related disorders

por Willemsen, Rob, Kooy, R. Frank
Publicado 2023

Combination Therapy in Fragile X Syndrome; Possibilities and Pitfalls Illustrated by Targeting the mGluR5 and GABA Pathway Simultaneously

por Zeidler, Shimriet, de Boer, Helen, Hukema, Renate K., Willemsen, Rob
Publicado 2017

Editorial: Proceedings of the “Fourth International Conference of the FMR1 Premutation: Basic Mechanisms, Clinical Involvement and Therapy”

por Usdin, Karen, Rodriguez-Revenga, Laia, Willemsen, Rob, Hukema, Renate, Giulivi, Cecilia
Publicado 2021

In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome

por Wang, Tiantian, de Kok, Laura, Willemsen, Rob, Elgersma, Ype, Borst, J. Gerard G.
Publicado 2015

Allopregnanolone Improves Locomotor Activity and Arousal in the Aged CGG Knock-in Mouse Model of Fragile X-Associated Tremor/Ataxia Syndrome

por Schwartzer, Jared J., Garcia-Arocena, Dolores, Jamal, Amanda, Izadi, Ali, Willemsen, Rob, Berman, Robert F.
Publicado 2021

Dopaminergic Neuronal Loss and Dopamine-Dependent Locomotor Defects in Fbxo7-Deficient Zebrafish

por Zhao, Tianna, Zondervan-van der Linde, Herma, Severijnen, Lies-Anne, Oostra, Ben A., Willemsen, Rob, Bonifati, Vincenzo
Publicado 2012

Generation and Characterization of Fmr1 Knockout Zebrafish

por den Broeder, Marjo J., van der Linde, Herma, Brouwer, Judith R., Oostra, Ben A., Willemsen, Rob, Ketting, René F.
Publicado 2009

Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles(†)

por Tassone, Flora, De Rubeis, Silvia, Carosi, Chiara, La Fata, Giorgio, Serpa, Gisele, Raske, Christopher, Willemsen, Rob, Hagerman, Paul J., Bagni, Claudia
Publicado 2011

Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI)

por Sherman, Stephanie L, Curnow, Eliza C, Easley, Charles A, Jin, Peng, Hukema, Renate K, Tejada, Maria Isabel, Willemsen, Rob, Usdin, Karen
Publicado 2014

BC RNA Mislocalization in the Fragile X Premutation

por Muslimov, Ilham A., Eom, Taesun, Iacoangeli, Anna, Chuang, Shih-Chieh, Hukema, Renate K., Willemsen, Rob, Stefanov, Dimitre G., Wong, Robert K. S., Tiedge, Henri
Publicado 2018

Inducible expression of human C9ORF72 36× G(4)C(2) hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

por Riemslagh, Fréderike W., van der Toorn, Esmay C., Verhagen, Rob F. M., Maas, Alex, Bosman, Laurens W. J., Hukema, Renate K., Willemsen, Rob
Publicado 2021

Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval

por Silva, Claudia Tamar, Kors, Jan A., Amin, Najaf, Dehghan, Abbas, Witteman, Jacqueline C. M., Willemsen, Rob, Oostra, Ben A., van Duijn, Cornelia M., Isaacs, Aaron
Publicado 2015

Reduction of Fmr1 mRNA Levels Rescues Pathological Features in Cortical Neurons in a Model of FXTAS

por Drozd, Malgorzata, Delhaye, Sébastien, Maurin, Thomas, Castagnola, Sara, Grossi, Mauro, Brau, Frédéric, Jarjat, Marielle, Willemsen, Rob, Capovilla, Maria, Hukema, Renate K., Lalli, Enzo, Bardoni, Barbara
Publicado 2019

Proteomic Profiling of Exosomes Leads to the Identification of Novel Biomarkers for Prostate Cancer

por Duijvesz, Diederick, Burnum-Johnson, Kristin E., Gritsenko, Marina A., Hoogland, A. Marije, Vredenbregt-van den Berg, Mirella S., Willemsen, Rob, Luider, Theo, Paša-Tolić, Ljiljana, Jenster, Guido
Publicado 2013

FMRpolyG-positive inclusions in CNS and non-CNS organs of a fragile X premutation carrier with fragile X-associated tremor/ataxia syndrome

por Buijsen, Ronald AM, Sellier, Chantal, Severijnen, Lies-Anne WFM, Oulad-Abdelghani, Mustapha, Verhagen, Rob FM, Berman, Robert F, Charlet-Berguerand, Nicolas, Willemsen, Rob, Hukema, Renate K
Publicado 2014

Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates

por Haify, Saif N., Mankoe, Ruchira S. D., Boumeester, Valerie, van der Toorn, Esmay C., Verhagen, Rob F. M., Willemsen, Rob, Hukema, Renate K., Bosman, Laurens W. J.
Publicado 2020

Paradoxical effect of baclofen on social behavior in the fragile X syndrome mouse model

por Zeidler, Shimriet, Pop, Andreea S., Jaafar, Israa A., de Boer, Helen, Buijsen, Ronald A. M., de Esch, Celine E. F., Nieuwenhuizen‐Bakker, Ingeborg, Hukema, Renate K., Willemsen, Rob
Publicado 2018

A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function

por Okray, Zeynep, de Esch, Celine EF, Van Esch, Hilde, Devriendt, Koen, Claeys, Annelies, Yan, Jiekun, Verbeeck, Jelle, Froyen, Guy, Willemsen, Rob, de Vrij, Femke MS, Hassan, Bassem A
Publicado 2015

HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

por Riemslagh, Frederike W., Lans, Hannes, Seelaar, Harro, Severijnen, Lies-Anne W. F. M., Melhem, Shamiram, Vermeulen, Wim, Aronica, Eleonora, Pasterkamp, R. Jeroen, van Swieten, John C., Willemsen, Rob
Publicado 2019

Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models

por Quint, Wim H., Tadema, Kirke C. D., Kokke, Nina C. C. J., Meester-Smoor, Magda A., Miller, Adam C., Willemsen, Rob, Klaver, Caroline C. W., Iglesias, Adriana I.
Publicado 2023