Temozolomide-induced increase of tumorigenicity can be diminished by targeting of mitochondria in in vitro models of patient individual glioblastoma

por William, Doreen, Walther, Madlin, Schneider, Björn, Linnebacher, Michael, Classen, Carl Friedrich
Publicado 2018

Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme

por William, Doreen, Mokri, Poroshista, Lamp, Nora, Linnebacher, Michael, Classen, Carl Friedrich, Erbersdobler, Andreas, Schneider, Björn
Publicado 2017

The miR-183/96/182 cluster is upregulated in glioblastoma carrying EGFR amplification

por Schneider, Björn, William, Doreen, Lamp, Nora, Zimpfer, Annette, Henker, Christian, Classen, Carl Friedrich, Erbersdobler, Andreas
Publicado 2022

Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies

por William, Doreen, Mullins, Christina Susanne, Schneider, Björn, Orthmann, Andrea, Lamp, Nora, Krohn, Mathias, Hoffmann, Annika, Classen, Carl-Friedrich, Linnebacher, Michael
Publicado 2017

The tuberculosis necrotizing toxin is an NAD(+) and NADP(+) glycohydrolase with distinct enzymatic properties

por Tak, Uday, Vlach, Jiri, Garza-Garcia, Acely, William, Doreen, Danilchanka, Olga, de Carvalho, Luiz Pedro Sório, Saad, Jamil S., Niederweis, Michael
Publicado 2019

Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model

por Clausing, Maximilian, William, Doreen, Preussler, Matthias, Biedermann, Julia, Grützmann, Konrad, Richter, Susan, Buchholz, Frank, Temme, Achim, Schröck, Evelin, Klink, Barbara
Publicado 2022

A Humanized Yeast Phenomic Model of Deoxycytidine Kinase to Predict Genetic Buffering of Nucleoside Analog Cytotoxicity

por Santos, Sean M., Icyuz, Mert, Pound, Ilya, William, Doreen, Guo, Jingyu, McKinney, Brett A., Niederweis, Michael, Rodgers, John, Hartman, John L.
Publicado 2019

Treatment of Pheochromocytoma Cells with Recurrent Cycles of Hypoxia: A New Pseudohypoxic In Vitro Model

por Helm, Jana, Drukewitz, Stephan, Poser, Isabel, Richter, Susan, Friedemann, Markus, William, Doreen, Mohr, Hermine, Nölting, Svenja, Robledo, Mercedes, Bornstein, Stefan R., Eisenhofer, Graeme, Bechmann, Nicole
Publicado 2022

Targeted Quantification of Carbon Metabolites Identifies Metabolic Progression Markers and an Undiagnosed Case of SDH-Deficient Clear Cell Renal Cell Carcinoma in a German Cohort

por William, Doreen, Erdmann, Kati, Ottemöller, Jonas, Mangelis, Anastasios, Conrad, Catleen, Peitzsch, Mirko, Schröck, Evelin, Eisenhofer, Graeme, Zacharis, Aristeidis, Füssel, Susanne, Aust, Daniela, Klink, Barbara, Richter, Susan
Publicado 2021

Patient-Derived Organoids of Cholangiocarcinoma

por Maier, Christopher Fabian, Zhu, Lei, Nanduri, Lahiri Kanth, Kühn, Daniel, Kochall, Susan, Thepkaysone, May-Linn, William, Doreen, Grützmann, Konrad, Klink, Barbara, Betge, Johannes, Weitz, Jürgen, Rahbari, Nuh N., Reißfelder, Christoph, Schölch, Sebastian
Publicado 2021

Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids

por Naumann, Max, Czempiel, Tabea, Lößner, Anna Jana, Pape, Kristin, Beyreuther, Elke, Löck, Steffen, Drukewitz, Stephan, Hennig, Alexander, von Neubeck, Cläre, Klink, Barbara, Krause, Mechthild, William, Doreen, Stange, Daniel E., Bütof, Rebecca, Dietrich, Antje
Publicado 2022

Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms

por Pape, Kristin, Lößner, Anna J., William, Doreen, Czempiel, Tabea, Beyreuther, Elke, Klimova, Anna, Lehmann, Claudia, Schmäche, Tim, Merker, Sebastian R., Naumann, Max, Ada, Anne-Marlen, Baenke, Franziska, Seidlitz, Therese, Bütof, Rebecca, Dietrich, Antje, Krause, Mechthild, Weitz, Jürgen, Klink, Barbara, von Neubeck, Cläre, Stange, Daniel E.
Publicado 2022

Optimizing Genetic Workup in Pheochromocytoma and Paraganglioma by Integrating Diagnostic and Research Approaches

por Gieldon, Laura, William, Doreen, Hackmann, Karl, Jahn, Winnie, Jahn, Arne, Wagner, Johannes, Rump, Andreas, Bechmann, Nicole, Nölting, Svenja, Knösel, Thomas, Gudziol, Volker, Constantinescu, Georgiana, Masjkur, Jimmy, Beuschlein, Felix, Timmers, Henri JLM, Canu, Letizia, Pacak, Karel, Robledo, Mercedes, Aust, Daniela, Schröck, Evelin, Eisenhofer, Graeme, Richter, Susan, Klink, Barbara
Publicado 2019

Plasma extracellular vesicle messenger RNA profiling identifies prognostic EV signature for non-invasive risk stratification for survival prediction of patients with pancreatic duc...

por Han, Yi, Drobisch, Pascal, Krüger, Alexander, William, Doreen, Grützmann, Konrad, Böthig, Lukas, Polster, Heike, Seifert, Lena, Seifert, Adrian M., Distler, Marius, Pecqueux, Mathieu, Riediger, Carina, Plodeck, Verena, Nebelung, Heiner, Weber, Georg F., Pilarsky, Christian, Kahlert, Ulf, Hinz, Ulf, Roth, Susanne, Hackert, Thilo, Weitz, Jürgen, Wong, Fang Cheng, Kahlert, Christoph
Publicado 2023