Do Inactivation Mechanisms Rather than Adaptation Hold the Key to Understanding Ryanodine Receptor Channel Gating?

por Sitsapesan, Rebecca, Williams, Alan J.
Publicado 2000

A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment

por Mukherjee, Saptarshi, Thomas, N. Lowri, Williams, Alan J.
Publicado 2012

Functional Characterization of the Cardiac Ryanodine Receptor Pore-Forming Region

por Euden, Joanne, Mason, Sammy A., Williams, Alan J.
Publicado 2013

Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating

por Mukherjee, Saptarshi, Thomas, N. Lowri, Williams, Alan J.
Publicado 2016

An Anionic Ryanoid, 10-O-succinoylryanodol, Provides Insights into the Mechanisms Governing the Interaction of Ryanoids and the Subsequent Altered Function of Ryanodine-receptor Ch...

por Tanna, Bhavna, Welch, William, Ruest, Luc, Sutko, John L., Williams, Alan J.
Publicado 2003

Interactions of a Reversible Ryanoid (21-Amino-9α-Hydroxy-Ryanodine) with Single Sheep Cardiac Ryanodine Receptor Channels

por Tanna, Bhavna, Welch, William, Ruest, Luc, Sutko, John L., Williams, Alan J.
Publicado 1998

The Interaction of a Neutral Ryanoid with the Ryanodine Receptor Channel Provides Insights into the Mechanisms by Which Ryanoid Binding Is Modulated by Voltage

por Tanna, Bhavna, Welch, William, Ruest, Luc, Sutko, John L., Williams, Alan J.
Publicado 2000

Ryanoid Modification of the Cardiac Muscle Ryanodine Receptor Channel Results in Relocation of the Tetraethylammonium Binding Site

por Tanna, Bhavna, Welch, William, Ruest, Luc, Sutko, John L., Williams, Alan J.
Publicado 2001

Investigations of the Contribution of a Putative Glycine Hinge to Ryanodine Receptor Channel Gating

por Euden, Joanne, Mason, Sammy A., Viero, Cedric, Thomas, N. Lowri, Williams, Alan J.
Publicado 2013

A Systemized Approach to Investigate Ca(2+) Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes

por Jones, Aled R., Edwards, David H., Cummins, Michael J., Williams, Alan J., George, Christopher H.
Publicado 2016

Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides

por Troczka, Bartlomiej J., Williams, Alan J., Williamson, Martin S., Field, Linda M., Lüemmen, Peter, Davies, T.G. Emyr
Publicado 2015

The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptide...

por Mason, Sammy A., Viero, Cedric, Euden, Joanne, Bannister, Mark, West, Duncan, Chen, S.R. Wayne, Williams, Alan J.
Publicado 2012

Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain

por Handhle, Ahmed, Ormonde, Chloe E., Thomas, N. Lowri, Bralesford, Catherine, Williams, Alan J., Lai, F. Anthony, Zissimopoulos, Spyros
Publicado 2016

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia

por Williams, Alan J., Bannister, Mark L., Thomas, N. Lowri, Sikkel, Markus B., Mukherjee, Saptarshi, Maxwell, Chloe, MacLeod, Kenneth T., George, Christopher H.
Publicado 2016

Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current

por Sikkel, Markus B., Collins, Thomas P., Rowlands, Christina, Shah, Mit, O'Gara, Peter, Williams, Alan J., Harding, Sian E., Lyon, Alexander R., MacLeod, Kenneth T.
Publicado 2013

Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart

por Dhanjal, Tarvinder S., Lellouche, Nicolas, von Ruhland, Christopher J., Abehsira, Guillaume, Edwards, David H., Dubois-Randé, Jean-Luc, Moschonas, Konstantinos, Teiger, Emmanuel, Williams, Alan J., George, Christopher H.
Publicado 2017

Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1

por Wei, Risheng, Wang, Xue, Zhang, Yan, Mukherjee, Saptarshi, Zhang, Lei, Chen, Qiang, Huang, Xinrui, Jing, Shan, Liu, Congcong, Li, Shuang, Wang, Guangyu, Xu, Yaofang, Zhu, Sujie, Williams, Alan J, Sun, Fei, Yin, Chang-Cheng
Publicado 2016

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor

por Bannister, Mark L, Alvarez‐Laviada, Anita, Thomas, N Lowri, Mason, Sammy A, Coleman, Sharon, du Plessis, Christo L, Moran, Abbygail T, Neill‐Hall, David, Osman, Hasnah, Bagley, Mark C, MacLeod, Kenneth T, George, Christopher H, Williams, Alan J
Publicado 2016