Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights

por Lazic, Stanley E., Semenova, Elizaveta, Williams, Dominic P.
Publicado 2020

Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

por Antoine, Daniel James, Williams, Dominic P., Kipar, Anja, Laverty, Hugh, Park, B. Kevin
Publicado 2020

Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity

por Antoine, Daniel James, Williams, Dominic P., Kipar, Anja, Laverty, Hugh, Park, B. Kevin
Publicado 2020

Characterization of a functional C3A liver spheroid model

por Gaskell, Harriet, Sharma, Parveen, Colley, Helen E., Murdoch, Craig, Williams, Dominic P., Webb, Steven D.
Publicado 2016

Novel in vitro and mathematical models for the prediction of chemical toxicity

por Williams, Dominic P., Shipley, Rebecca, Ellis, Marianne J., Webb, Steve, Ward, John, Gardner, Iain, Creton, Stuart
Publicado 2013

Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity

por Bell, Catherine C., Chouhan, Bhavik, Andersson, Linda C., Andersson, Håkan, Dear, James W., Williams, Dominic P., Söderberg, Magnus
Publicado 2020

Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose–response relationship in murine versus human cell lines and implicat...

por McCarron, Eamon P, Williams, Dominic P, Antoine, Daniel J, Kipar, Anja, Lemm, Jana, Stehr, Sebastian, Welters, Ingeborg D
Publicado 2015

Multiscale modelling of drug transport and metabolism in liver spheroids

por Leedale, Joseph A., Kyffin, Jonathan A., Harding, Amy L., Colley, Helen E., Murdoch, Craig, Sharma, Parveen, Williams, Dominic P., Webb, Steven D., Bearon, Rachel N.
Publicado 2020

The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine

por Jolly, Carol E., Douglas, Oisin, Kamalian, Laleh, Jenkins, Rosalind E., Beckett, Alison J., Penman, Sophie L., Williams, Dominic P., Monshouwer, Mario, Simic, Damir, Snoeys, Jan, Park, B. Kevin, Chadwick, Amy E.
Publicado 2020

Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist

por Thaventhiran, Thilipan, Alhumeed, Naif, Yeang, Han XA, Sethu, Swaminathan, Downey, Jocelyn S, Alghanem, Ahmad F, Olayanju, Adedamola, Smith, Emma L, Cross, Michael J, Webb, Steven D, Williams, Dominic P, Bristow, Adrian, Ball, Christina, Stebbings, Richard, Sathish, Jean G
Publicado 2014

A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function

por Karageorgis, Anastassia, Lenhard, Stephen C., Yerby, Brittany, Forsgren, Mikael F., Liachenko, Serguei, Johansson, Edvin, Pilling, Mark A., Peterson, Richard A., Yang, Xi, Williams, Dominic P., Ungersma, Sharon E., Morgan, Ryan E., Brouwer, Kim L. R., Jucker, Beat M., Hockings, Paul D.
Publicado 2018

Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress

por O’Brien, Katie A., McNally, Ben D., Sowton, Alice P., Murgia, Antonio, Armitage, James, Thomas, Luke W., Krause, Fynn N., Maddalena, Lucas A., Francis, Ian, Kavanagh, Stefan, Williams, Dominic P., Ashcroft, Margaret, Griffin, Julian L., Lyon, Jonathan J., Murray, Andrew J.
Publicado 2021

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

por Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, van Houdt, Jos, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus
Publicado 2018