siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2

por Elkayam, Elad, Parmar, Rubina, Brown, Christopher R., Willoughby, Jennifer L., Theile, Christopher S., Manoharan, Muthiah, Joshua-Tor, Leemor
Publicado 2017

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2

por Elkayam, Elad, Parmar, Rubina, Brown, Christopher R., Willoughby, Jennifer L., Theile, Christopher S., Manoharan, Muthiah, Joshua-Tor, Leemor
Publicado 2017

Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence

por Willoughby, Jennifer L. S., George, Kelly, Roberto, Mark P., Chin, Hang Gyeong, Stoiber, Patrick, Shin, Hyunjin, Pedamallu, Chandra Sekhar, Schaus, Scott E., Fitzgerald, Kevin, Shah, Jagesh, Hansen, Ulla
Publicado 2020

Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins

por Yunes, Sarah A., Willoughby, Jennifer L. S., Kwan, Julian H., Biagi, Jessica M., Pokharel, Niranjana, Chin, Hang Gyeong, York, Emily A., Su, Kuan-Chung, George, Kelly, Shah, Jagesh V., Emili, Andrew, Schaus, Scott E., Hansen, Ulla
Publicado 2022

Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Tar...

por Guenther, Dale C., Mori, Shohei, Matsuda, Shigeo, Gilbert, Jason A., Willoughby, Jennifer L. S., Hyde, Sarah, Bisbe, Anna, Jiang, Yongfeng, Agarwal, Saket, Madaoui, Mimouna, Janas, Maja M., Charisse, Klaus, Maier, Martin A., Egli, Martin, Manoharan, Muthiah
Publicado 2022

Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo

por Jahns, Hartmut, Taneja, Nate, Willoughby, Jennifer L S, Akabane-Nakata, Masaaki, Brown, Christopher R, Nguyen, Tuyen, Bisbe, Anna, Matsuda, Shigeo, Hettinger, Matt, Manoharan, Rajar M, Rajeev, Kallanthottathil G, Maier, Martin A, Zlatev, Ivan, Charisse, Klaus, Egli, Martin, Manoharan, Muthiah
Publicado 2021

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

por Willoughby, Jennifer L.S., Chan, Amy, Sehgal, Alfica, Butler, James S., Nair, Jayaprakash K., Racie, Tim, Shulga-Morskaya, Svetlana, Nguyen, Tuyen, Qian, Kun, Yucius, Kristina, Charisse, Klaus, van Berkel, Theo J.C., Manoharan, Muthiah, Rajeev, Kallanthottathil G., Maier, Martin A., Jadhav, Vasant, Zimmermann, Tracy S.
Publicado 2018

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model

por Rajasekaran, Devaraja, Siddiq, Ayesha, Willoughby, Jennifer L.S., Biagi, Jessica M., Christadore, Lisa M., Yunes, Sarah A., Gredler, Rachel, Jariwala, Nidhi, Robertson, Chadia L., Akiel, Maaged A., Shen, Xue-Ning, Subler, Mark A., Windle, Jolene J., Schaus, Scott E., Fisher, Paul B., Hansen, Ulla, Sarkar, Devanand
Publicado 2015

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis

por Butler, James S., Chan, Amy, Costelha, Susete, Fishman, Shannon, Willoughby, Jennifer L. S., Borland, Todd D., Milstein, Stuart, Foster, Donald J., Gonçalves, Paula, Chen, Qingmin, Qin, June, Bettencourt, Brian R., Sah, Dinah W., Alvarez, Rene, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Fitzgerald, Kevin, Meyers, Rachel E., Nochur, Saraswathy V., Saraiva, Maria J., Zimmermann, Tracy S.
Publicado 2016

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

por Nair, Jayaprakash K., Attarwala, Husain, Sehgal, Alfica, Wang, Qianfan, Aluri, Krishna, Zhang, Xuemei, Gao, Minggeng, Liu, Ju, Indrakanti, Ramesh, Schofield, Sally, Kretschmer, Philip, Brown, Christopher R., Gupta, Swati, Willoughby, Jennifer L.S., Boshar, Julie A., Jadhav, Vasant, Charisse, Klaus, Zimmermann, Tracy, Fitzgerald, Kevin, Manoharan, Muthiah, Rajeev, Kallanthottathil G., Akinc, Akin, Hutabarat, Renta, Maier, Martin A.
Publicado 2017

Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.

por Park, Se-Hyung, Helsley, Robert N., Fadhul, Taghreed, Willoughby, Jennifer L.S., Noetzli, Leila, Tu, Ho-Chou, Solheim, Marie H., Fujisaka, Shiho, Pan, Hui, Dreyfuss, Jonathan M., Bons, Joanna, Rose, Jacob, King, Christina D., Schilling, Birgit, Lusis, Aldons J., Pan, Calvin, Gupta, Manoj, Kulkarni, Rohit N., Fitzgerald, Kevin, Kern, Philip A., Divanovic, Senad, Kahn, C. Ronald, Softic, Samir
Publicado 2023