In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1–Rok–Myosin-II and JNK signalling

por Khoo, Peytee, Allan, Kirsten, Willoughby, Lee, Brumby, Anthony M., Richardson, Helena E.
Publicado 2013

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila

por Doggett, Karen, Turkel, Nezaket, Willoughby, Lee F., Ellul, Jason, Murray, Michael J., Richardson, Helena E., Brumby, Anthony M.
Publicado 2015

PTP61F Mediates Cell Competition and Mitigates Tumorigenesis

por La Marca, John E., Willoughby, Lee F., Allan, Kirsten, Portela, Marta, Goh, Pei Kee, Tiganis, Tony, Richardson, Helena E.
Publicado 2021

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

por Willoughby, Lee F., Schlosser, Tanja, Manning, Samuel A., Parisot, John P., Street, Ian P., Richardson, Helena E., Humbert, Patrick O., Brumby, Anthony M.
Publicado 2013

The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in Drosophila melanogaster through Maintaining a Progenitor-like Cell State

por Turkel, Nezaket, Sahota, Virender K., Bolden, Jessica E., Goulding, Karen R., Doggett, Karen, Willoughby, Lee F., Blanco, Enrique, Martin-Blanco, Enrique, Corominas, Montserrat, Ellul, Jason, Aigaki, Toshiro, Richardson, Helena E., Brumby, Anthony M.
Publicado 2013

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

por Zoranovic, Tamara, Manent, Jan, Willoughby, Lee, Matos de Simoes, Ricardo, La Marca, John E., Golenkina, Sofya, Cuiping, Xia, Gruber, Susanne, Angjeli, Belinda, Kanitz, Elisabeth Eva, Cronin, Shane J. F., Neely, G. Gregory, Wernitznig, Andreas, Humbert, Patrick O., Simpson, Kaylene J., Mitsiades, Constantine S., Richardson, Helena E., Penninger, Josef M.
Publicado 2018