Multilineage transduction of resident lung cells in vivo by AAV2/8 for α(1)-antitrypsin gene therapy

por Payne, Julia G, Takahashi, Ayuko, Higgins, Michelle I, Porter, Emily L, Suki, Bela, Balazs, Alejandro, Wilson, Andrew A
Publicado 2016

Activation of the c‐Jun N‐terminal kinase pathway aggravates proteotoxicity of hepatic mutant Z alpha1‐antitrypsin

por Pastore, Nunzia, Attanasio, Sergio, Granese, Barbara, Castello, Raffaele, Teckman, Jeffrey, Wilson, Andrew A., Ballabio, Andrea, Brunetti‐Pierri, Nicola
Publicado 2017

Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo

por Repasy, Teresa, Lee, Jinhee, Marino, Simeone, Martinez, Nuria, Kirschner, Denise E., Hendricks, Gregory, Baker, Stephen, Wilson, Andrew A., Kotton, Darrell N., Kornfeld, Hardy
Publicado 2013

Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes

por Werder, Rhiannon B., Kaserman, Joseph E., Packer, Michael S., Lindstrom-Vautrin, Jonathan, Villacorta-Martin, Carlos, Young, Lauren E., Aratyn-Schaus, Yvonne, Gregoire, Francine, Wilson, Andrew A.
Publicado 2021

CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells

por Werder, Rhiannon B., Liu, Tao, Abo, Kristine M., Lindstrom-Vautrin, Jonathan, Villacorta-Martin, Carlos, Huang, Jessie, Hinds, Anne, Boyer, Nathan, Bullitt, Esther, Liesa, Marc, Silverman, Edwin K., Kotton, Darrell N., Cho, Michael H., Zhou, Xiaobo, Wilson, Andrew A.
Publicado 2022

The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells

por Werder, Rhiannon B., Berthiaume, Kayleigh A., Merritt, Carly, Gallagher, Marissa, Villacorta-Martin, Carlos, Wang, Feiya, Bawa, Pushpinder, Malik, Vidhi, Lyons, Shawn M., Basil, Maria C., Morrisey, Edward E., Kotton, Darrell N., Zhou, Xiaobo, Cho, Michael H., Wilson, Andrew A.
Publicado 2023

A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells

por Kaserman, Joseph E., Hurley, Killian, Dodge, Mark, Villacorta-Martin, Carlos, Vedaie, Marall, Jean, Jyh-Chang, Liberti, Derek C., James, Marianne F., Higgins, Michelle I., Lee, Nora J., Washko, George R., San Jose Estepar, Raul, Teckman, Jeffrey, Kotton, Darrell N., Wilson, Andrew A.
Publicado 2020

Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

por Giadone, Richard M., Liberti, Derek C., Matte, Taylor M., Rosarda, Jessica D., Torres-Arancivia, Celia, Ghosh, Sabrina, Diedrich, Jolene K., Pankow, Sandra, Skvir, Nicholas, Jean, J.C., Yates, John R., Wilson, Andrew A., Connors, Lawreen H., Kotton, Darrell N., Wiseman, R. Luke, Murphy, George J.
Publicado 2020

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α(1)-antitrypsin deficiency

por Segeritz, Charis-Patricia, Rashid, Sheikh Tamir, de Brito, Miguel Cardoso, Serra, Maria Paola, Ordonez, Adriana, Morell, Carola Maria, Kaserman, Joseph E., Madrigal, Pedro, Hannan, Nicholas R.F., Gatto, Laurent, Tan, Lu, Wilson, Andrew A., Lilley, Kathryn, Marciniak, Stefan J., Gooptu, Bibek, Lomas, David A., Vallier, Ludovic
Publicado 2018

Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium

por Abo, Kristine M., Sainz de Aja, Julio, Lindstrom-Vautrin, Jonathan, Alysandratos, Konstantinos-Dionysios, Richards, Alexsia, Garcia-de-Alba, Carolina, Huang, Jessie, Hix, Olivia T., Werder, Rhiannon B., Bullitt, Esther, Hinds, Anne, Falconer, Isaac, Villacorta-Martin, Carlos, Jaenisch, Rudolf, Kim, Carla F., Kotton, Darrell N., Wilson, Andrew A.
Publicado 2022

Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity

por Kaserman, Joseph E., Werder, Rhiannon B., Wang, Feiya, Matte, Taylor, Higgins, Michelle I., Dodge, Mark, Lindstrom-Vautrin, Jonathan, Bawa, Pushpinder, Hinds, Anne, Bullitt, Esther, Caballero, Ignacio S., Shi, Xu, Gerszten, Robert E., Brunetti-Pierri, Nicola, Liesa, Marc, Villacorta-Martin, Carlos, Hollenberg, Anthony N., Kotton, Darrell N., Wilson, Andrew A.
Publicado 2022

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes

por Scoon, Whitney A., Mancio-Silva, Liliana, Suder, Ellen L., Villacorta-Martin, Carlos, Lindstrom-Vautrin, Jonathan, Bernbaum, John G., Mazur, Steve, Johnson, Reed F., Olejnik, Judith, Flores, Elizabeth Y., Mithal, Aditya, Wang, Feiya, Hume, Adam J., Kaserman, Joseph E., March-Riera, Sandra, Wilson, Andrew A., Bhatia, Sangeeta N., Mühlberger, Elke, Mostoslavsky, Gustavo
Publicado 2022

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

por Huang, Jessie, Hume, Adam J., Abo, Kristine M., Werder, Rhiannon B., Villacorta-Martin, Carlos, Alysandratos, Konstantinos-Dionysios, Beermann, Mary Lou, Simone-Roach, Chantelle, Lindstrom-Vautrin, Jonathan, Olejnik, Judith, Suder, Ellen L., Bullitt, Esther, Hinds, Anne, Sharma, Arjun, Bosmann, Markus, Wang, Ruobing, Hawkins, Finn, Burks, Eric J., Saeed, Mohsan, Wilson, Andrew A., Mühlberger, Elke, Kotton, Darrell N.
Publicado 2020

Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells

por Wilson, Andrew A., Ying, Lei, Liesa, Marc, Segeritz, Charis-Patricia, Mills, Jason A., Shen, Steven S., Jean, Jyhchang, Lonza, Geordie C., Liberti, Derek C., Lang, Alex H., Nazaire, Jean, Gower, Adam C., Müeller, Franz-Josef, Mehta, Pankaj, Ordóñez, Adriana, Lomas, David A., Vallier, Ludovic, Murphy, George J., Mostoslavsky, Gustavo, Spira, Avrum, Shirihai, Orian S., Ramirez, Maria I., Gadue, Paul, Kotton, Darrell N.
Publicado 2015

Recombinant Lloviu virus as a tool to study viral replication and host responses

por Hume, Adam J., Heiden, Baylee, Olejnik, Judith, Suder, Ellen L., Ross, Stephen, Scoon, Whitney A., Bullitt, Esther, Ericsson, Maria, White, Mitchell R., Turcinovic, Jacquelyn, Thao, Tran T. N., Hekman, Ryan M., Kaserman, Joseph E., Huang, Jessie, Alysandratos, Konstantinos-Dionysios, Toth, Gabor E., Jakab, Ferenc, Kotton, Darrell N., Wilson, Andrew A., Emili, Andrew, Thiel, Volker, Connor, John H., Kemenesi, Gabor, Cifuentes, Daniel, Mühlberger, Elke
Publicado 2022

Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses

por Hume, Adam J., Heiden, Baylee, Olejnik, Judith, Suder, Ellen L., Ross, Stephen, Scoon, Whitney A., Bullitt, Esther, Ericsson, Maria, White, Mitchell R., Turcinovic, Jacquelyn, Thao, Tran T. N., Hekman, Ryan M., Kaserman, Joseph E., Huang, Jessie, Alysandratos, Konstantinos-Dionysios, Toth, Gabor E., Jakab, Ferenc, Kotton, Darrell N., Wilson, Andrew A., Emili, Andrew, Thiel, Volker, Connor, John H., Kemenesi, Gabor, Cifuentes, Daniel, Mühlberger, Elke
Publicado 2022

Characterization of the COPD alveolar niche using single-cell RNA sequencing

por Sauler, Maor, McDonough, John E., Adams, Taylor S., Kothapalli, Neeharika, Barnthaler, Thomas, Werder, Rhiannon B., Schupp, Jonas C., Nouws, Jessica, Robertson, Matthew J., Coarfa, Cristian, Yang, Tao, Chioccioli, Maurizio, Omote, Norihito, Cosme, Carlos, Poli, Sergio, Ayaub, Ehab A., Chu, Sarah G., Jensen, Klaus H., Gomez, Jose L., Britto, Clemente J., Raredon, Micha Sam B., Niklason, Laura E., Wilson, Andrew A., Timshel, Pascal N., Kaminski, Naftali, Rosas, Ivan O.
Publicado 2022

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

por Hekman, Ryan M., Hume, Adam J., Goel, Raghuveera Kumar, Abo, Kristine M., Huang, Jessie, Blum, Benjamin C., Werder, Rhiannon B., Suder, Ellen L., Paul, Indranil, Phanse, Sadhna, Youssef, Ahmed, Alysandratos, Konstantinos D., Padhorny, Dzmitry, Ojha, Sandeep, Mora-Martin, Alexandra, Kretov, Dmitry, Ash, Peter E.A., Verma, Mamta, Zhao, Jian, Patten, J.J., Villacorta-Martin, Carlos, Bolzan, Dante, Perea-Resa, Carlos, Bullitt, Esther, Hinds, Anne, Tilston-Lunel, Andrew, Varelas, Xaralabos, Farhangmehr, Shaghayegh, Braunschweig, Ulrich, Kwan, Julian H., McComb, Mark, Basu, Avik, Saeed, Mohsan, Perissi, Valentina, Burks, Eric J., Layne, Matthew D., Connor, John H., Davey, Robert, Cheng, Ji-Xin, Wolozin, Benjamin L., Blencowe, Benjamin J., Wuchty, Stefan, Lyons, Shawn M., Kozakov, Dima, Cifuentes, Daniel, Blower, Michael, Kotton, Darrell N., Wilson, Andrew A., Mühlberger, Elke, Emili, Andrew
Publicado 2020

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

por Hekman, Ryan M., Hume, Adam J., Goel, Raghuveera Kumar, Abo, Kristine M., Huang, Jessie, Blum, Benjamin C., Werder, Rhiannon B., Suder, Ellen L., Paul, Indranil, Phanse, Sadhna, Youssef, Ahmed, Alysandratos, Konstantinos D., Padhorny, Dzmitry, Ojha, Sandeep, Mora-Martin, Alexandra, Kretov, Dmitry, Ash, Peter E.A., Verma, Mamta, Zhao, Jian, Patten, J.J., Villacorta-Martin, Carlos, Bolzan, Dante, Perea-Resa, Carlos, Bullitt, Esther, Hinds, Anne, Tilston-Lunel, Andrew, Varelas, Xaralabos, Farhangmehr, Shaghayegh, Braunschweig, Ulrich, Kwan, Julian H., McComb, Mark, Basu, Avik, Saeed, Mohsan, Perissi, Valentina, Burks, Eric J., Layne, Matthew D., Connor, John H., Davey, Robert, Cheng, Ji-Xin, Wolozin, Benjamin L., Blencowe, Benjamin J., Wuchty, Stefan, Lyons, Shawn M., Kozakov, Dima, Cifuentes, Daniel, Blower, Michael, Kotton, Darrell N., Wilson, Andrew A., Mühlberger, Elke, Emili, Andrew
Publicado 2021