Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2‐dioxygenase deficiency in the liver is responsible for homogentisic acid‐derived ochronotic pigme...

por Wilson, Peter J. M., Ranganath, Lakshminarayan R., Bou‐Gharios, George, Gallagher, James A., Hughes, Juliette H.
Publicado 2020

Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces

por Hughes, Juliette H., Keenan, Craig M., Sutherland, Hazel, Edwards, Henry R., Wilson, Peter J. M., Ranganath, Lakshminarayan R., Jarvis, Jonathan C., Bou-Gharios, George, Gallagher, James A.
Publicado 2020

Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria

por Hughes, Juliette H., Wilson, Peter J. M., Sutherland, Hazel, Judd, Shirley, Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Bou‐Gharios, George, Ranganath, Lakshminarayan R., Gallagher, James A.
Publicado 2020

Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the ge...

por Hughes, Juliette H, Liu, Ke, Plagge, Antonius, Wilson, Peter J M, Sutherland, Hazel, Norman, Brendan P, Hughes, Andrew T, Keenan, Craig M, Milan, Anna M, Sakai, Takao, Ranganath, Lakshminarayan R, Gallagher, James A, Bou-Gharios, George
Publicado 2019

Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria

por Norman, Brendan P., Davison, Andrew S., Hickton, Bryony, Ross, Gordon A., Milan, Anna M., Hughes, Andrew T., Wilson, Peter J. M., Sutherland, Hazel, Hughes, Juliette H., Roberts, Norman B., Bou-Gharios, George, Gallagher, James A., Ranganath, Lakshminarayan R.
Publicado 2022