Hypoxia-activated prodrugs: paths forward in the era of personalised medicine

por Hunter, Francis W, Wouters, Bradly G, Wilson, William R
Publicado 2016

An Intratumor Pharmacokinetic/Pharmacodynamic Model for the Hypoxia-Activated Prodrug Evofosfamide (TH-302): Monotherapy Activity is Not Dependent on a Bystander Effect()()

por Hong, Cho Rong, Wilson, William R., Hicks, Kevin O.
Publicado 2018

Design of Optimized Hypoxia-Activated Prodrugs Using Pharmacokinetic/Pharmacodynamic Modeling

por Foehrenbacher, Annika, Secomb, Timothy W., Wilson, William R., Hicks, Kevin O.
Publicado 2013

Studies Towards Hypoxia-Activated Prodrugs of PARP Inhibitors

por Dickson, Benjamin D., Wong, Way Wua, Wilson, William R., Hay, Michael P.
Publicado 2019

DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A

por Stornetta, Alessia, Villalta, Peter W., Gossner, Frederike, Wilson, William R., Balbo, Silvia, Sturla, Shana J.
Publicado 2017

Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect

por Yang, Mimi M., Yarragudi, Sasi Bhushan, Jamieson, Stephen M. F., Tang, Mingtan, Wilson, William R., Wu, Zimei
Publicado 2022

Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures

por Hong, Cho R., Bogle, Gib, Wang, Jingli, Patel, Kashyap, Pruijn, Frederik B., Wilson, William R., Hicks, Kevin O.
Publicado 2018

1378. Evaluation of the In vitro Activity of Meropenem-Vaborbactam Against Carbapenem-Resistant Enterobacteriaceae, Including Isolates Resistant to Ceftazidime–Avibactam

por Wilson, William R, Kline, Ellen, Jones, Chelsea, Morder, Kristin, Clancy, Cornelius J, Nguyen, M Hong, Shields, Ryan K
Publicado 2018

A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

por McKeage, Mark J, Gu, Yongchuan, Wilson, William R, Hill, Andrew, Amies, Karen, Melink, Teresa J, Jameson, Michael B
Publicado 2011

The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104

por Foehrenbacher, Annika, Patel, Kashyap, Abbattista, Maria R., Guise, Chris P., Secomb, Timothy W., Wilson, William R., Hicks, Kevin O.
Publicado 2013

An agent-based model for drug-radiation interactions in the tumour microenvironment: Hypoxia-activated prodrug SN30000 in multicellular tumour spheroids

por Mao, Xinjian, McManaway, Sarah, Jaiswal, Jagdish K., Patel, Priyanka B., Wilson, William R., Hicks, Kevin O., Bogle, Gib
Publicado 2018

Zinc Finger Nuclease Mediated Knockout of ADP-Dependent Glucokinase in Cancer Cell Lines: Effects on Cell Survival and Mitochondrial Oxidative Metabolism

por Richter, Susan, Morrison, Shona, Connor, Tim, Su, Jiechuang, Print, Cristin G., Ronimus, Ron S., McGee, Sean L., Wilson, William R.
Publicado 2013

PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours

por McKeage, Mark J, Jameson, Michael B, Ramanathan, Ramesh K, Rajendran, Joseph, Gu, Yongchuan, Wilson, William R, Melink, Teresa J, Tchekmedyian, N Simon
Publicado 2012

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

por Hay, Michael P., Shin, Hong Nam, Wong, Way Wua, Sahimi, Wan Wan, Vaz, Aaron T.D., Yadav, Pooja, Anderson, Robert F., Hicks, Kevin O., Wilson, William R.
Publicado 2019

247. Sustaining Excellence of Care During a Fluid Shortage: Snapshot of Antibiotic Mitigation Strategies Following Hurricane Maria

por Marini, Rachel V, Potoski, Brian A, Wilson, William R, Falcione, Bonnie, Clarke, Lloyd, L’Altrelli, Alfred, Khadem, Tina, Shields, Ryan K, Clancy, Cornelius J, Nguyen, M Hong, Gross, Paige, Viehman, J Alexander, Then, Janine
Publicado 2018

Impact of Tumour Hypoxia on Evofosfamide Sensitivity in Head and Neck Squamous Cell Carcinoma Patient-Derived Xenograft Models

por Harms, Julia K., Lee, Tet-Woo, Wang, Tao, Lai, Amy, Kee, Dennis, Chaplin, John M., McIvor, Nick P., Hunter, Francis W., Macann, Andrew M. J., Wilson, William R., Jamieson, Stephen M.F.
Publicado 2019

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

por Guise, Chris P., Abbattista, Maria R., Anderson, Robert F., Li, Dan, Taghipouran, Rana, Tsai, Angela, Lee, Su Jung, Smaill, Jeff B., Denny, William A., Hay, Michael P., Wilson, William R., Hicks, Kevin O., Patterson, Adam V.
Publicado 2020

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice

por Gu, Yongchuan, Chang, Tony T.-A., Wang, Jingli, Jaiswal, Jagdish K., Edwards, David, Downes, Noel J., Liyanage, H. D. Sarath, Lynch, Courtney R. H., Pruijn, Frederik B., Hickey, Anthony J. R., Hay, Michael P., Wilson, William R., Hicks, Kevin O.
Publicado 2017

Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104

por Benito, Juliana, Shi, Yuexi, Szymanska, Barbara, Carol, Hernan, Boehm, Ingrid, Lu, Hongbo, Konoplev, Sergej, Fang, Wendy, Zweidler-McKay, Patrick A., Campana, Dario, Borthakur, Gautam, Bueso-Ramos, Carlos, Shpall, Elizabeth, Thomas, Deborah A., Jordan, Craig T., Kantarjian, Hagop, Wilson, William R., Lock, Richard, Andreeff, Michael, Konopleva, Marina
Publicado 2011