Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex

por Winden, Kellen D., Pham, Truc T., Teaney, Nicole A., Ruiz, Juan, Chen, Ryan, Chen, Cidi, Sahin, Mustafa
Publicado 2023

A Systems Level, Functional Genomics Analysis of Chronic Epilepsy

por Winden, Kellen D., Karsten, Stanislav L., Bragin, Anatol, Kudo, Lili C., Gehman, Lauren, Ruidera, Josephine, Geschwind, Daniel H., Engel, Jerome
Publicado 2011

The organization of the transcriptional network in specific neuronal classes

por Winden, Kellen D, Oldham, Michael C, Mirnics, Karoly, Ebert, Philip J, Swan, Christo H, Levitt, Pat, Rubenstein, John L, Horvath, Steve, Geschwind, Daniel H
Publicado 2009

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

por Sundberg, Maria, Pinson, Hannah, Smith, Richard S., Winden, Kellen D., Venugopal, Pooja, Tai, Derek J. C., Gusella, James F., Talkowski, Michael E., Walsh, Christopher A., Tegmark, Max, Sahin, Mustafa
Publicado 2021

Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

por Di Nardo, Alessia, Lenoël, Isadora, Winden, Kellen D., Rühmkorf, Alina, Modi, Meera E., Barrett, Lee, Ercan-Herbst, Ebru, Venugopal, Pooja, Behne, Robert, Lopes, Carla A.M., Kleiman, Robin J., Bettencourt-Dias, Mónica, Sahin, Mustafa
Publicado 2020

16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons

por Buttermore, Elizabeth D., Anderson, Nickesha C., Chen, Pin-Fang, Makhortova, Nina R., Kim, Kristina H., Wafa, Syed M. A., Dwyer, Sean, Micozzi, John M., Winden, Kellen D., Zhang, Bo, Han, Min-Joon, Kleiman, Robin J., Brownstein, Catherine A., Sahin, Mustafa, Gonzalez-Heydrich, Joseph
Publicado 2022